TRPC1 Deficiency Impairs the Endothelial Progenitor Cell Function via Inhibition of Calmodulin/eNOS Pathway [0.03%]
TRPC1缺乏通过抑制钙调蛋白/eNOS途径损害内皮祖细胞功能
Lai-Ling Du,Zhida Shen,Zhengwei Li et al.
Lai-Ling Du et al.
Endothelial progenitor cells (EPCs) promote angiogenesis and play a pivotal role in endothelial repair and re-endothelialization after vascular injury. Transient receptor potential-canonical1 (TRPC1) has been recently implied to play import...
The Potential of Stem Cells and Stem Cell-Derived Exosomes in Treating Cardiovascular Diseases [0.03%]
干细胞及干细胞源外泌体治疗心血管疾病潜力巨大
Jing Ni,Yuxi Sun,Zheng Liu
Jing Ni
In recent years, the cardiac protective mechanisms of stem cells have become a research focus. Increasing evidence has suggested that stem cells release vesicles, including exosomes and micro-vesicles. The content of these vesicles relies o...
Patient-Specific Cardiovascular Computational Modeling: Diversity of Personalization and Challenges [0.03%]
个性化心血管计算模型的多样性及挑战
Richard A Gray,Pras Pathmanathan
Richard A Gray
Patient-specific computer models have been developed representing a variety of aspects of the cardiovascular system spanning the disciplines of electrophysiology, electromechanics, solid mechanics, and fluid dynamics. These physiological me...
SDF 1-alpha Attenuates Myocardial Injury Without Altering the Direct Contribution of Circulating Cells [0.03%]
SDF-1α减轻心肌损伤但不影响循环细胞的直接贡献
Andrew B Goldstone,Cassandra E Burnett,Jeffery E Cohen et al.
Andrew B Goldstone et al.
Stromal cell-derived factor 1-alpha (SDF) is a potent bone marrow chemokine capable of recruiting circulating progenitor populations to injured tissue. SDF has known angiogenic capabilities, but bone marrow-derived cellular contributions to...
GLP-1 Improves Diastolic Function and Survival in Heart Failure with Preserved Ejection Fraction [0.03%]
GLP-1改善保留射血分数心力衰竭的舒张功能和生存率
T Dung Nguyen,Yasushige Shingu,Paulo A Amorim et al.
T Dung Nguyen et al.
Heart failure with preserved ejection fraction (HFpEF) has emerged as a public health burden with currently no effective medication. We assessed the treatment effects of the incretin hormone glucagon-like peptide-1 (GLP-1) on cardiac metabo...
Clinical Applications of Patient-Specific Models: The Case for a Simple Approach [0.03%]
个性化模型的临床应用——简洁方法的优势案例分析
Jeffrey W Holmes,Joost Lumens
Jeffrey W Holmes
Over the past several decades, increasingly sophisticated models of the heart have provided important insights into cardiac physiology and are increasingly used to predict the impact of diseases and therapies on the heart. In an era of pers...
Effect of Aerobic Exercise on Treg and Th17 of Rats with Ischemic Cardiomyopathy [0.03%]
有氧运动对心肌梗死后免疫细胞Tregs和Th17的影响研究
Zhisong Chen,Wenwen Yan,Yu Mao et al.
Zhisong Chen et al.
Immune activation and inflammation participate in the progression of chronic heart failure (CHF). Th17 cells and CD4+CD25+ regulatory T (Treg) cells both come from naive Th cells and share reciprocal development pathways but exhibit opposit...
Serum Exosomes Attenuate H2O2-Induced Apoptosis in Rat H9C2 Cardiomyocytes via ERK1/2 [0.03%]
血清外泌体通过ERK1/2途径减轻H2O2诱导的H9C2心肌细胞凋亡
Pengfei Li,Zhuyuan Liu,Yuan Xie et al.
Pengfei Li et al.
Exosomes are small-sized vesicles that can be released from cells into the serum. Exosomes play important roles in regulating many biological processes including cell proliferation, apoptosis, cell cycle, and metabolism. However, the roles ...
Enhanced Cardiac S100A1 Expression Improves Recovery from Global Ischemia-Reperfusion Injury [0.03%]
增强心脏S100A1表达可改善心肌梗死后功能恢复
S Jungi,X Fu,A Segiser et al.
S Jungi et al.
Gene-targeted therapy with the inotropic Ca2 + -sensor protein S100A1 rescues contractile function in post-ischemic heart failure and is being developed towards clinical trials. Its proven beneficial effect on cardiac metabolism and mitocho...
Retrograde Coronary Venous Infusion as a Delivery Strategy in Regenerative Cardiac Therapy: an Overview of Preclinical and Clinical Data [0.03%]
冠状静脉逆向递送作为心脏再生治疗的给药策略：临床前和临床数据概述
Wouter A Gathier,Dirk Jan van Ginkel,Mira van der Naald et al.
Wouter A Gathier et al.
An important aspect of cell therapy in the field of cardiac disease is safe and effective delivery of cells. Commonly used delivery strategies such as intramyocardial injection and intracoronary infusion both present with advantages and dis...