Mechano-chronotropic Unloading During the Acute Phase of Myocardial Infarction Markedly Reduces Infarct Size via the Suppression of Myocardial Oxygen Consumption [0.03%]
急性心肌梗死后急性期的机械减负荷通过抑制心肌耗氧量显著减少梗死面积
Genya Sunagawa,Keita Saku,Takahiro Arimura et al.
Genya Sunagawa et al.
The oxygen supply-demand imbalance is the fundamental pathophysiology of myocardial infarction (MI). Reducing myocardial oxygen consumption (MVO2) in acute MI (AMI) reduces infarct size. Since left ventricular (LV) mechanical work and heart...
Effect of Sodium Thiosulfate Postconditioning on Ischemia-Reperfusion Injury Induced Mitochondrial Dysfunction in Rat Heart [0.03%]
硫代硫酸钠对缺血再灌注诱导的大鼠心肌线粒体损伤的防治作用研究
Sriram Ravindran,Gino A Kurian
Sriram Ravindran
The recent research on the therapeutic applications of sodium thiosulfate (STS) has gained importance in the treatment of cardiovascular diseases. Progressively through the present work, we have demonstrated that postconditioning of isolate...
Effects of Percutaneous LVAD Support on Right Ventricular Load and Adaptation [0.03%]
植入左心室辅助装置对右心室负荷及重塑的影响
Jeffrey P Yourshaw,Prabodh Mishra,M Christopher Armstrong et al.
Jeffrey P Yourshaw et al.
Both operative and hemodynamic mechanisms have been implicated in right heart failure (RHF) following surgical left ventricular assist device (LVAD) implantation. We investigated the effects of percutaneous LVAD (pLVAD; Impella®, Abiomed) ...
Tirofiban Positively Regulates β1 Integrin and Favours Endothelial Cell Growth on Polylactic Acid Biopolymer Vascular Scaffold (BVS) [0.03%]
替罗非班可通过上调β1整合素促进聚乳酸生物聚合物血管支架内皮细胞的增殖
Arturo Giordano,Simona Romano,Nicola Corcione et al.
Arturo Giordano et al.
An unexpectedly high incidence of thrombosis in patients that received the polylactic acid bioresorbable vascular scaffold (BVS) suggests a delayed/incomplete endothelial repair with this stent. The anti-platelet agent tirofiban stimulates ...
Reduced Myocardial Mitochondrial ROS Production in Mechanically Unloaded Hearts [0.03%]
机械卸载心脏中线粒体产生的心肌ROS减少
Daniel Scheiber,Elric Zweck,Tomas Jelenik et al.
Daniel Scheiber et al.
Mechanical ventricular unloading in advanced heart failure (HF) has been shown to induce reverse remodeling in myocardial tissues. Little is known about the impact of ventricular unloading on myocardial energy metabolism. We hypothesized th...
Inhibition of Aortic Valve Calcification by Local Delivery of Zoledronic Acid-an Experimental Study [0.03%]
利塞磷酸局部递送抑制主动脉瓣钙化-动物实验研究
Andreas Synetos,Konstantinos Toutouzas,Maria Drakopoulou et al.
Andreas Synetos et al.
The aim of this study was to evaluate in an experimental model of aortic valve (AV) stenosis the effectiveness of zoledronate on the inhibition of calcification. Sixteen New Zealand rabbits were placed on vitamin D-enriched diet for 3 weeks...
Development of an Off-the-Shelf Tissue-Engineered Sinus Valve for Transcatheter Pulmonary Valve Replacement: a Proof-of-Concept Study [0.03%]
一种现成的组织工程肺动脉瓣窦移植物用于经导管肺瓣膜置换的概念验证研究
Sarah E Motta,Emanuela S Fioretta,Petra E Dijkman et al.
Sarah E Motta et al.
Tissue-engineered heart valves with self-repair and regeneration properties may overcome the problem of long-term degeneration of currently used artificial prostheses. The aim of this study was the development and in vivo proof-of-concept o...
miRNA Profiling of Exosomes from Spontaneous Hypertensive Rats Using Next-Generation Sequencing [0.03%]
应用下一代测序技术进行自发性高血压大鼠外泌体的miRNA图谱分析
Xiaoyan Liu,Wen Yuan,Lei Yang et al.
Xiaoyan Liu et al.
The role and miRNA expression profile of exosomes in hypertension remain largely unknown. Therefore, next-generation sequencing was used to define the miRNA expression profile of plasma exosomes in spontaneously hypertensive rats (SHRs), th...
Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes: a Critical Step for Drug Development and Cell Therapy [0.03%]
多能干细胞来源的心肌细胞向成熟方向分化：药物研发和细胞治疗的关键步骤
Shi Hua Tan,Lei Ye
Shi Hua Tan
Cardiomyocytes derived from human pluripotent stem cells (hPSCs) are emerging as an invaluable alternative to primarily sourced cardiomyocytes. The potentially unlimited number of hPSC-derived cardiomyocytes (hPSC-CMs) that may be obtained ...
Predicting the Time Course of Ventricular Dilation and Thickening Using a Rapid Compartmental Model [0.03%]
基于快速组模块模型的室腔容积扩大和壁厚变化预测研究
Colleen M Witzenburg,Jeffrey W Holmes
Colleen M Witzenburg
The ability to predict long-term growth and remodeling of the heart in individual patients could have important clinical implications, but the time to customize and run current models makes them impractical for routine clinical use. Therefo...