Left Ventricular Diastolic Myocardial Stiffness and End-Diastolic Myofibre Stress in Human Heart Failure Using Personalised Biomechanical Analysis [0.03%]
基于个性化 biomechanical 分析的左心室充盈障碍型心力衰竭患者心肌僵硬度和舒张末期肌纤维应力的研究
Zhinuo J Wang,Vicky Y Wang,Chris P Bradley et al.
Zhinuo J Wang et al.
Understanding the aetiology of heart failure with preserved (HFpEF) and reduced (HFrEF) ejection fraction requires knowledge of biomechanical factors such as diastolic myocardial stiffness and stress. Cine CMR images and intra-ventricular p...
Melatonin and ST Segment Elevation Acute Myocardial Infarction-the "Forgotten Cardioprotective Therapy" Strikes Again [0.03%]
褪黑素与ST段抬高型急性心肌梗死——“被遗忘的心脏保护疗法”再次出击
Alberto Dominguez-Rodriguez,Nestor Baez-Ferrer,Pedro Abreu-Gonzalez
Alberto Dominguez-Rodriguez
Circulating MicroRNAs: a Potential Biomarker for Cardiac Damage, Inflammatory Response, and Left Ventricular Function Recovery in Pediatric Viral Myocarditis [0.03%]
小儿病毒性心肌炎循环微小RNA：心脏损伤、炎症反应及左室功能恢复的潜在生物标志物
Lior Goldberg,Tal Tirosh-Wagner,Amir Vardi et al.
Lior Goldberg et al.
Viral myocarditis (VM) can be a life-threatening event resulting in cardiac failure, chronic cardiomyopathy, and death. VM typically includes three phases, i.e., acute, subacute, and resolution/chronic. We prospectively investigated cardiac...
Speckle-Tracking Echocardiographic Strain Analysis Reliably Estimates Degree of Acute LV Unloading During Mechanical LV Support by Impella [0.03%]
应变为超声心动图的斑点追踪可可靠地估算Impella左心室辅助下的急性左心室卸载程度
Nadjib Hammoudi,Shin Watanabe,Olympia Bikou et al.
Nadjib Hammoudi et al.
Non-invasive means of evaluating appropriate cardiac unloading remain to be established. We hypothesized that myocardial deformation assessed by echocardiographic speckle-tracking strain analysis can reliably estimate the degree of left ven...
The Application of Induced Pluripotent Stem Cells in Cardiac Disease Modeling and Drug Testing [0.03%]
诱导多能干细胞在心脏疾病建模和药物检测中的应用
Lingqun Ye,Xuan Ni,Zhen-Ao Zhao et al.
Lingqun Ye et al.
In recent decades, cardiovascular diseases have become the greatest health threat to human beings, and thus it is particularly important to explore the subtle underlying pathogenesis of cardiovascular diseases. Although many molecular pathw...
The Exosome-Derived Biomarker in Atherosclerosis and Its Clinical Application [0.03%]
动脉粥样硬化外泌体生物标志物及临床应用进展
Mengmeng Lu,Shuaifang Yuan,Shicheng Li et al.
Mengmeng Lu et al.
Exosomes are now accepted as potential biomarkers in cardiovascular disease development, especially in atherosclerosis. Atherosclerosis is a leading cause of cardiovascular disease-related death and morbidity, accounting for one-fifth of al...
Current Modalities and Mechanisms Underlying Cardioprotection by Ischemic Conditioning [0.03%]
缺血适应的心脏保护的目前手段和机制研究
John H Rosenberg,John H Werner,Michael J Moulton et al.
John H Rosenberg et al.
Ischemic preconditioning is a process which serves to mitigate reperfusion injury. Preconditioning of the heart can be achieved through natural, pharmacological, and mechanical means. Mechanical preconditioning appears to have the greatest ...
Endothelial Progenitor Cells in Heart Failure: an Authentic Expectation for Potential Future Use and a Lack of Universal Definition [0.03%]
心力衰竭中的内皮祖细胞：真正的期待和缺乏统一的定义
Andie H Djohan,Ching-Hui Sia,Poay Sian Lee et al.
Andie H Djohan et al.
Congestive heart failure (CHF) is a prevalent disease (especially among the elderly) with high mortality and morbidity rates. The pathological hallmark of CHF is a loss of cardiomyocytes leading to cardiac fibrosis and dysfunctional cardiac...
RANKL Expression Is Increased in Circulating Mononuclear Cells of Patients with Calcific Aortic Stenosis [0.03%]
钙化主动脉瓣狭窄患者单个核细胞中的RANKL表达增强
Marcello Rattazzi,Elisabetta Faggin,Elisa Bertacco et al.
Marcello Rattazzi et al.
We aimed to investigate whether the expression of the OPG/RANK/RANKL triad in peripheral blood mononuclear cells (PBMC) and circulating levels of markers of ectopic mineralization (OPG, FGF-23, PPi) are modified in patients with calcific ao...
Zi Wang,Xuan Su,Muhammad Ashraf et al.
Zi Wang et al.
Despite substantial advances in the development of medical and interventional strategies in ischemic and non-ischemic heart diseases, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Stem cell th...