Distinct Myocardial Remodelling Profiles in Athletes: A Comparative Analysis Across Sporting Disciplines [0.03%]
运动员心肌重塑特征的差异性：不同运动项目间的比较分析
Zayed M Altowerqi
Zayed M Altowerqi
Despite being recognized for over a century, the athlete's heart (AH) a result of intense and regular physical training remains a topic of clinical debate. This physiological cardiac remodelling involves structural, electrical, and function...
Exosomal miRNAs: A New Frontier in Cardiovascular Disease Diagnosis and Treatment [0.03%]
外泌体miRNA在心血管疾病诊断和治疗中的新进展
Sun Qingpiao,Zhang Yi
Sun Qingpiao
Exosomes are small vesicles secreted by a variety of cells surrounded by a lipid bilayer membrane and containing a variety of biomolecules, of which microRNAs (miRNAs) are the most abundant. Exosomal miRNAs are involved in the development o...
Evaluation of CACNA1C-Positive Patients Evaluated in a Tertiary Genetic Heart Rhythm Clinic [0.03%]
三级遗传心律诊所评估的CACNA1C阳性患者的评估
Liwei Yu,Raquel Neves,Martijn M Bos et al.
Liwei Yu et al.
Genetic variants in CACNA1C are associated with several cardiac and neurologic conditions. We conducted a retrospective review of patients evaluated and treated who presented with a pathogenic (P), likely pathogenic (LP), or variant of unce...
Modeling the Hemodynamic Impact of Y-incision Aortic Annular Enlargements on Aortic Valve Replacement and Valve-in-Valve Procedures [0.03%]
主动脉瓣置换和瓣中瓣治疗主动脉环Y型切开扩大术的血流动力学影响仿真研究
Mia Bonini,Surya Sanjay,Maximilian Balmus et al.
Mia Bonini et al.
Y-incision aortic annular enlargement (Y-AAE) with surgical aortic valve replacement (SAVR) may improve outflow tract hemodynamics and valve-in-valve (ViV) outcomes but could increase thrombosis risk. We used computational fluid dynamics to...
Hypoxia/reoxygenation-induced Glycolysis Mediates Myocardial Ischemia-reperfusion Injury Through Promoting the Lactylation of GPX4 [0.03%]
缺氧/复氧诱导的糖酵解通过促进GPX4乳酰化介导心肌缺血再灌注损伤
Yihua Wang,Qiang Yue,Xiurong Song et al.
Yihua Wang et al.
Myocardial ischemia-reperfusion injury (MIRI) is an injury mechanism of myocardial infarction, related to ferroptosis and glycolysis. Lactate produced by glycolysis promotes protein lactylation. This study aimed to investigate the correlati...
Redesign of Implantable Cardiac Device Workflow Improves Remote Monitoring Timeliness and Heart Failure Alert Metrics [0.03%]
植入式心脏设备工作流程的改造提高了远程监测的及时性和心力衰竭警报指标
Craig M Stolen,Molly E Kupfer,Karen Tomes et al.
Craig M Stolen et al.
Integration into clinical workflow remains a barrier to realizing the benefits of remote heart failure monitoring technologies. A workflow redesign program was conducted at 27 cardiology sites to improve implementation of heart failure remo...
Exercise Empowerment: A Multifaceted Anatomy in Managing Diabetic Myocardial Disorder [0.03%]
运动赋能：糖尿病性心肌病的多方位干预措施研究
Congfei Chen,Longfei Xu,Kun Wang et al.
Congfei Chen et al.
Diabetic myocardial disorder is characterized by myocardial dysfunction in diabetes mellitus patients, independent of other heart disease causes like coronary artery disease or hypertension. This condition threatens the well-being of patien...
Yangcheng Xue,Zhuoran Jia,Shichu Liang et al.
Yangcheng Xue et al.
Early diagnosis and treatment of atrial cardiomyopathy(ACM) are crucial for patients with atrial fibrillation(AF), and further exploration of its biomarkers remains necessary. High-throughput sequencing of exosomal miRNAs was performed on b...
Endothelial Glycocalyx Damage and Restoration Following Vascular Stent Implantation [0.03%]
血管内皮糖萼在支架置入术中的损伤与修复
Belay Tesfamariam
Belay Tesfamariam
The endothelial glycocalyx layer forms interface between the luminal surface and circulating blood, and consists of cell surface membrane-bound glycosaminoglycan chains and transmembrane embedded glycoproteins and proteoglycans, such as gly...
Cardiac Magnetic Resonance-Derived Left Ventricular Mechanical Dispersion Improves Risk Stratification of Hypertrophic Cardiomyopathy and its Correlations with Scar Heterogeneity [0.03%]
基于心脏磁共振的左心室机械离散度可改善肥厚性心肌病的风险分层及其与瘢痕异质性的相关性
Xiaoying Zhao,Yujiao Song,Li Zhang et al.
Xiaoying Zhao et al.
The accuracy of prevalent risk models recommended by American Heart Association/American College of Cardiology(AHA/ACC) and European Society of Cardiology(ESC) for hypertrophic cardiomyopathy(HCM) patients is suboptimal. We assessed the uti...