Amyloid Cardiomyopathy in the Rare Transthyretin Tyr78Phe Mutation [0.03%]
罕见的转甲状腺素蛋白Tyr78Phe突变性淀粉样心肌病
Giacomo Tini,Pier Filippo Vianello,Chiara Gemelli et al.
Giacomo Tini et al.
Tyr78Phe is a rare pathogenic transthyretin (TTR) mutation. Few previous reports described a late-onset hereditary transthyretin-related amyloidosis (ATTR-m) form with a variable phenotype, mainly dominated by neurological manifestations. W...
Minjun Xu,Yi Duan,Junjie Xiao
Minjun Xu
Vascular diseases induced by diabetes and obesity (e.g., atherosclerosis) are associated with insulin resistance (IR), which leads to endothelial cell dysfunction due to metabolic disorder and oxidative stress. Research conducted by Cai sho...
Evaluation of the CorInnova Heart Assist Device in an Acute Heart Failure Model [0.03%]
CorInnova心脏辅助装置在急性心力衰竭模型中的评估
Erica C Hord,Christina M Bolch,Egemen Tuzun et al.
Erica C Hord et al.
While the number of patients supported with temporary cardiac assist is growing, the existing devices are limited by a multitude of complications, mostly related to contact with the blood. The CorInnova epicardial compressive heart assist d...
MicroRNA-29b-3p Targets SPARC Gene to Protect Cardiocytes against Autophagy and Apoptosis in Hypoxic-Induced H9c2 Cells [0.03%]
microRNA-29b-3p靶向SPARC基因保护缺氧诱导的H9c2心肌细胞自噬和凋亡损伤
Shu Zhou,Dazhou Lei,Faqin Bu et al.
Shu Zhou et al.
MicroRNAs participate in the regulation of abnormal cardiomyocyte apoptosis and autophagy, which leads to heart failure (HF). Lower miR-29b-3p levels were found in HF patients in this study. However, the role of miR-29b-3p in the molecular ...
Autonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans [0.03%]
自主神经调节可急性改善人类左心室应变
Nicole Tran,Zain Asad,Khaled Elkholey et al.
Nicole Tran et al.
Low-level transcutaneous vagus nerve stimulation at the tragus (LLTS) is anti-adrenergic. We aimed to evaluate the acute effects of LLTS on left ventricular (LV) function and autonomic tone. Patients with diastolic dysfunction and preserved...
Randomized Controlled Trial
Journal of cardiovascular translational research. 2019 Jun;12(3):221-230. DOI:10.1007/s12265-018-9853-6 2019
Release of Mitochondrial and Nuclear DNA During On-Pump Heart Surgery: Kinetics and Relation to Extracellular Vesicles [0.03%]
体外循环心脏手术中线粒体DNA和核DNA的释放及其与细胞外囊泡的关系
Anton Baysa,Anton Fedorov,Kirill Kondratov et al.
Anton Baysa et al.
During heart surgery with cardiopulmonary bypass (CPB), the release of mitochondrial (mtDNA) and nuclear DNA (nDNA) and their association to extracellular vesicles were investigated. In patients undergoing elective coronary artery bypass gr...
Identification and Functional Characterization of an ISL1 Mutation Predisposing to Dilated Cardiomyopathy [0.03%]
鉴定并功能表型了一个与扩张性心肌病相关的ISL1突变
Ying-Jia Xu,Zhang-Sheng Wang,Chen-Xi Yang et al.
Ying-Jia Xu et al.
Dilated cardiomyopathy (DCM) is the most prevalent cause of non-ischemic cardiac failure and the commonest indication for cardiac transplantation. Compelling evidence highlights the pivotal roles of genetic defects in the occurrence of DCM....
Yihua Bei,Chao Shi,Zhongrong Zhang et al.
Yihua Bei et al.
As the most populous country worldwide, China has ≈ 290 million patients with cardiovascular diseases (CVDs), representing the leading cause of death in Chinese population. The morbidity and mortality of CVDs are continuously rising. Here,...
Sex and Gender Differences in Ischemic Heart Disease: Endocrine Vascular Disease Approach (EVA) Study Design [0.03%]
缺血性心脏病的性别差异：内分泌血管病研究(EVA)的设计
Valeria Raparelli,Marco Proietti,Andrea Lenzi et al.
Valeria Raparelli et al.
Improvements in ischemic heart disease (IHD) management have been unbalanced between sexes, with coronary microvascular dysfunction considered the likely underlying reason. The Endocrine Vascular disease Approach (EVA) is an observational s...
Serum Extracellular Vesicles Retard H9C2 Cell Senescence by Suppressing miR-34a Expression [0.03%]
血清外泌体通过抑制miR-34a的表达来延缓H9C2细胞衰老
Yang Liu,Zhuyuan Liu,Yuan Xie et al.
Yang Liu et al.
Extracellular vesicles (EVs) are small-sized membrane-surrounded structures released from cells into the blood, which play important roles in regulating various biological processes. However, the role of EVs in Doxorubicin (DOX)-induced car...