A Durable Porcine Pericardial Surgical Bioprosthetic Heart Valve: a Proof of Concept [0.03%]
一种耐久的猪心包外科生物心脏瓣膜的概念验证研究
Benyamin Rahmani,Christopher McGregor,Guerard Byrne et al.
Benyamin Rahmani et al.
Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements. This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was...
Association of Genetic Polymorphisms in the Beta-1 Adrenergic Receptor with Recovery of Left Ventricular Ejection Fraction in Patients with Heart Failure [0.03%]
β1肾上腺素能受体基因多态性与心力衰竭患者左室射血分数恢复的相关性研究
Jasmine A Luzum,Joseph D English,Umair S Ahmad et al.
Jasmine A Luzum et al.
Two common genetic polymorphisms in the beta-1 adrenergic receptor (ADRB1 Ser49Gly [rs1801252] and Arg389Gly [rs1801253]) significantly affect receptor function in vitro. The objective of this study was to determine whether ADRB1 Ser49Gly a...
Profound Increase of Lung Airway Resistance in Heart Failure: a Potential Important Contributor for Dyspnea [0.03%]
心力衰竭中肺气道阻力的增加是导致呼吸困难的重要因素
Xiaohong Liu,Liuqing Yang,Dongmin Kwak et al.
Xiaohong Liu et al.
Dyspnea is a major symptom of heart failure (HF). Here, we have studied the lung remodeling and airway resistance in HF mice. We demonstrated that aortic banding-induced HF caused a dramatic decrease of lung compliance and an increase of lu...
Beyond Reperfusion: Acute Ventricular Unloading and Cardioprotection During Myocardial Infarction [0.03%]
缺血后超重构心保护中的急性室腔卸载作用研究进展
Jerry Curran,Daniel Burkhoff,Robert A Kloner
Jerry Curran
Heart failure is a major cause of morbidity and mortality around the world, and myocardial infarction is its leading cause. Myocardial infarction destroys viable myocardium, and this dead tissue is replaced by a non-contractile scar that re...
Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects Against Ventricular Fibrillation in a Porcine Model [0.03%]
急性心肌梗死早期应用胺碘酮可预防猪模型室颤发作
Stefan M Sattler,Anniek F Lubberding,Lasse Skibsbye et al.
Stefan M Sattler et al.
Ventricular fibrillation (VF) occurring in the first minutes to hours of acute myocardial infarction (AMI) is a frequent cause of death and treatment options are limited. The aim was to test whether early infusion of amiodarone 10 min after...
Exosomes in Cardiovascular Diseases and Treatment: Experimental and Clinical Aspects [0.03%]
心血管疾病的外泌体：实验与临床方面
Jing Wang,Chenglin Zhao,Junjie Xiao
Jing Wang
Cardiac Progenitor Cell-Derived Extracellular Vesicles: a Rising Star for Cardiac Repair and Regeneration [0.03%]
心脏祖细胞源外泌体在心脏修复与再生中的研究进展
Zhongrong Zhang,Yi Duan,Yihua Bei
Zhongrong Zhang
Upregulation of Circulating Cardiomyocyte-Enriched miR-1 and miR-133 Associate with the Risk of Coronary Artery Disease in Type 2 Diabetes Patients and Serve as Potential Biomarkers [0.03%]
2型糖尿病患者中循环富心肌细胞源miR-1及miR-133的上调与冠状动脉性心脏病发病风险相关并可作为潜在标志物
Haifa Abdulla Al-Muhtaresh,Abdel Halim Salem,Ghada Al-Kafaji
Haifa Abdulla Al-Muhtaresh
Circulating miRNAs are increasingly suggested as clinical biomarker for diseases. We evaluated the expression of circulating cardiomyocyte-enriched miR-1 and miR-133 by real-time PCR in blood from patients with type 2 diabetes (T2D) without...
lncRNA HOTAIR Protects Myocardial Infarction Rat by Sponging miR-519d-3p [0.03%]
长链非编码RNA HOTAIR通过海绵作用吸附miR-519d-3p对心肌梗死大鼠发挥保护作用
Dongying Zhang,Bingjian Wang,Min Ma et al.
Dongying Zhang et al.
Myocardial infarction (MI) is a cardiovascular disease with high morbidity and mortality. In this study, we focused on exploring the roles and underlying regulatory mechanisms of Hox transcript antisense intergenic RNA (HOTAIR) and miR-519d...
A Novel Wireless Left Atrial Pressure Monitoring System for Patients with Heart Failure, First Ex-Vivo and Animal Experience [0.03%]
一种新型无线左心房压力监测系统用于治疗心力衰竭患者，首次体外和动物实验体验
Leor Perl,Elina Soifer,Jozef Bartunek et al.
Leor Perl et al.
The V-LAP™ measures left atrial pressure (LAP) and enables bi-directional communications with an external unit, designed to monitor heart failure patients. We hereby describe the pre-clinical experience. Following an ex vivo phase, the sys...