The Influence of Aortic Valve Obstruction on the Hyperemic Intracoronary Physiology: Difference Between Resting Pd/Pa and FFR in Aortic Stenosis [0.03%]
主动脉瓣狭窄患者静息Pd/Pa与FFR的差异：主动脉瓣狭窄对冠状动脉充血生理的影响
Roberto Scarsini,Giovanni L De Maria,Giuseppe Di Gioia et al.
Roberto Scarsini et al.
The reliability of fractional flow reserve (FFR) in aortic stenosis (AS) has been questioned because of the uncertain response to vasodilators. A retrospective multicenter cohort of 114 AS patients who underwent coronary physiology assessme...
Juan-Juan Song,Zheng Ma,Juan Wang et al.
Juan-Juan Song et al.
Hypertension is the leading risk factor for global mortality and morbidity and remains the major preventable cause of cardiovascular diseases. Gender differences in risk factors and awareness, treatment, and control of hypertension have bee...
Mechanical Left Ventricular Unloading to Reduce Infarct Size During Acute Myocardial Infarction: Insight from Preclinical and Clinical Studies [0.03%]
术前和临床研究视角下的左心室辅助装置在急性心肌梗死溶栓治疗中减少梗塞面积的作用
Navin K Kapur,Lara Reyelt,Lija Swain et al.
Navin K Kapur et al.
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality. Pioneering preclinical work reported by Peter Maroko and Eugene Braunwald in 1971 identified oxygen supply and demand are primary determinants of myocardi...
Plasma Complement Protein C3a Level Was Associated with Abdominal Aortic Calcification in Patients on Hemodialysis [0.03%]
血透患者血浆补体C3a水平与腹主动脉钙化的关联性研究
Yaqin Wang,Yuanyi Miao,Kunjing Gong et al.
Yaqin Wang et al.
The complement system plays an important role in cardiovascular disease in patients on hemodialysis. Vascular calcification is also one of the major causes of cardiovascular disease. We want to investigate the relationship between complemen...
Protection of Myocardial Ischemia-Reperfusion by Therapeutic Hypercapnia: a Mechanism Involving Improvements in Mitochondrial Biogenesis and Function [0.03%]
二氧化碳吸入治疗心肌缺血-再灌注损伤的保护作用及其线粒体生物合成和功能改善有关
Laiting Chi,Nan Wang,Wanchao Yang et al.
Laiting Chi et al.
Previous studies proposed that acidic reperfusion may be a protective strategy for myocardial ischemia-reperfusion therapy with potential of clinical transformation. In this study, we investigated whether therapeutic hypercapnia could mimic...
TLR2-Dependent Reversible Oxidation of Connexin 43 at Cys260 Modifies Electrical Coupling After Experimental Myocardial Ischemia/Reperfusion [0.03%]
toll样受体2依赖的Connexin 43第260位半胱氨酸可逆氧化修饰影响心肌缺血再灌注后缝隙连接通讯功能
Florian Jürgen Raimann,Stefan Dröse,Erik Bonke et al.
Florian Jürgen Raimann et al.
We have shown previously that during myocardial ischemia/reperfusion (MI/R), toll-like receptor 2 (TLR2) signaling regulates connexin 43 (Cx43) subcellular localization and function and dampens arrhythmia formation. We aimed to identify sit...
A Promising Treatment of Distal Entry Tears Located in Branched Area of Abdominal Aorta With Coil-Stent Tear Occlusion Device: an Animal Experiment [0.03%]
一种治疗夹层累及腹主动脉分叉部位破口的新型腔内修复装置：动物实验研究
Yu Shen,Wenquan Rao,Junjun Liu et al.
Yu Shen et al.
This study aims to evaluate the effect of coil-stent tear occlusion device in treating entry tears located in branched area of abdominal aorta. An abdominal aortic dissection animal model was constructed by mesh suturing method. The animal ...
Long Noncoding RNA-CERNA1 Stabilized Atherosclerotic Plaques in apolipoprotein E-/- Mice [0.03%]
长非编码RNA-CERNA1通过稳定易损斑块在apoE基因敲除小鼠中抑制动脉粥样硬化的发展
Wei Lu,Xiaoying He,Le Su et al.
Wei Lu et al.
Atherosclerosis is predicted to be the primary cause of death in the world by 2020. Changes in atherosclerotic plaque composition will lead to acute coronary syndromes. Although the studies on the molecular mechanisms of long noncoding RNA ...
Kdm6A Protects Against Hypoxia-Induced Cardiomyocyte Apoptosis via H3K27me3 Demethylation of Ncx Gene [0.03%]
Kdm6A通过去甲基化Ncx基因上H3K27me3保护心肌细胞免受缺氧诱导的凋亡
Yu Li,Xin Quan,Xialing Li et al.
Yu Li et al.
Molecular events involved in acute myocardial infarction (AMI) still remain unclear. A rat AMI model and cardiomyocytes cultured in vitro were used to mimic hypoxic conditions, and the profiles of histone methylation-related gene expression...