Intracoronary Stenting and Restenosis - Randomized Trial of Drug-Eluting Stent Implantation or Drug-Coated Balloon Angioplasty According to Neointima Morphology in Drug-Eluting Stent REstenosis 5: Rationale and Design of the ISAR-DESIRE 5 Trial [0.03%]
冠脉内支架置入与再狭窄：药物洗脱支架植入和药物涂层球囊血管成形术的随机对照试验（ISAR-DESIRE 5）——设计及立题依据
Fiorenzo Simonetti,Felix Voll,Fernando Alfonso et al.
Fiorenzo Simonetti et al.
In-stent restenosis (ISR) is the leading cause of revascularization failure, occurring in up to 10% of patients within 10 years after drug-eluting stent (DES) implantation, and is associated with increased mortality and rehospitalization. G...
Small Interfering RNA (siRNA) for Cardiorenal Disease: Mechanistic Insights from Preclinical and Clinical Studies [0.03%]
小干扰RNA（siRNA）治疗心血管肾脏疾病：来自临床前和临床研究的见解
Sukriti Wadehra,Shareen Singh,Sandeep Kaur et al.
Sukriti Wadehra et al.
Small Interfering RNA (siRNA) is a class of double-stranded, noncoding RNA that silences pathogenic mRNA through the process of RNA interference (RNAi). Its medical application is extensive, particularly in targeting genes associated with c...
The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock [0.03%]
缺血性心源性休克的急性心血管和线粒体反应
Oskar Kjærgaard Hørsdal,Peter Hartmund Frederiksen,Ole Kristian Lerche Helgestad et al.
Oskar Kjærgaard Hørsdal et al.
The acute pathophysiological changes after myocardial ischemia complicated by cardiogenic shock (CS) remain poorly defined, especially regarding compensatory mechanisms and myocardial mitochondrial function. We investigated immediate cardio...
Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke [0.03%]
中性粒细胞与白蛋白比率与急性缺血性卒中治疗后90天预后的相关性分析
Peian Liu,Lianhong Ji,Jiale Gan et al.
Peian Liu et al.
The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in relation to albumin levels for acute ischemic stroke (AIS) remains unclear. This study examined the correlation between inflammatory markers and nutritional status t...
Yuyao Wang,Weijing Liu,Yanyan Hao et al.
Yuyao Wang et al.
Following myocardial infarction (MI), endothelial cell proliferation drives neovascularization to support cardiac regeneration. While myeloid-derived growth factor (Mydgf) is known to promote cardiac repair post-injury, yet its mechanism in...
Development of a Nomogram Model to Predict the Risk of Postoperative Delirium in Cardiac Surgery Patients [0.03%]
心血管手术患者术后谵妄风险预测的列线图模型研究
Zikomo Gaudence Kipanga,Zexiang Bao,Marvel Gyeyock Tella et al.
Zikomo Gaudence Kipanga et al.
Postoperative delirium (POD) is a common and severe complication following cardiac surgery, with an incidence of about 65% in older patients. This study aimed to develop a predictive model for POD in patients aged ≥ 18 years, to enhance ea...
Circulating Extracellular Vesicles Predict Complications after Cardiac Surgery [0.03%]
循环外泌体可预测心脏手术术后并发症
Yu-Peng Jian,Yue-Ming Peng,Xiao-Jun Liu et al.
Yu-Peng Jian et al.
Cardiac surgery with cardiopulmonary bypass (CPB) may lead to many postoperative complications. However, many complications cannot be predicted in time using the current clinical methods, or the prediction is not sufficiently accurate, resu...
Investigating the Therapeutic Potential of miRNA-137-3p/383-5p/PGC-1α Signalling Nexus Against Cardiac Hypertrophy [0.03%]
探究miRNA-137-3p/383-5p/PGC-1α信号轴治疗心肌肥厚的潜力
Khadam Hussain,Somia Khurram,Muhammad Yousaf et al.
Khadam Hussain et al.
Pathological growth of cardiomyocytes known as cardiac hypertrophy (CH). Differential expressions of miRNAs have an immense therapeutic potential against cardiac hypertrophy. The current study aim is to evaluate the therapeutic potential of...
Identification of Plasma Lipidomic Signatures Associated with Coronary Plaque Vulnerability [0.03%]
与冠状动脉斑块易损性相关的血浆脂质组学标志物识别
Yanyan Gong,Chen Zhao,Lixin Jia et al.
Yanyan Gong et al.
The objective of this study was to identify plasma lipid signatures associated with plaque vulnerability. We retrospectively evaluated coronary plaque in 99 patients using optical coherence tomography (OCT) and quantified 489 plasma lipids....
The Individual and Joint Associations of Systolic Blood Pressure Variability and Arterial Stiffness with Cardiovascular Disease: A Prospective Cohort Study [0.03%]
收缩压变异性和动脉僵硬度与心血管疾病个体和联合关联的前瞻性队列研究
Ming Gao,Wei Pan,Tianqi Ma et al.
Ming Gao et al.
Systolic blood pressure variability (SBPV) and arterial stiffness index (ASI) are risk factors for cardiovascular diseases (CVD), but their independent and combined effects remain unclear. This study investigated their associations using da...