Protein Thermodynamic Destabilization in the Assessment of Pathogenicity of a Variant of Uncertain Significance in Cardiac Myosin Binding Protein C [0.03%]
心肌肌球蛋白结合蛋白C位点致病性评估中的蛋白质热力学不稳定性
Maria Rosaria Pricolo,Elías Herrero-Galán,Cristina Mazzaccara et al.
Maria Rosaria Pricolo et al.
In the era of next generation sequencing (NGS), genetic testing for inherited disorders identifies an ever-increasing number of variants whose pathogenicity remains unclear. These variants of uncertain significance (VUS) limit the reach of ...
Intra-myocardial Delivery of a Novel Thermosensitive Hydrogel Inhibits Post-infarct Heart Failure After Degradation in Rat [0.03%]
一种新型热敏性水凝胶的心肌内递送在大鼠中降解后可抑制心梗后心力衰竭
Ying Wen,Xiao-Yan Li,Ze-Yong Li et al.
Ying Wen et al.
Whether intra-myocardial delivery of hydrogel can prevent post-infarct heart failure (HF) in a long follow-up period, especially after it is degraded, remains unclear. In this study, Dex-PCL-HEMA/PNIPAAm (DPHP) hydrogel was delivered into p...
Jan Kottwitz,Katelyn A Bruno,Jan Berg et al.
Jan Kottwitz et al.
There is an unmet need for accurate and practical screening to detect myocarditis. We sought to test the hypothesis that the extent of acute myocarditis, measured by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (C...
Heparin Administration, but Not Myocardial Ischemia or Necrosis, Leads to Midkine Elevation [0.03%]
肝素注射，而非心肌缺血或坏死，导致中期激肽增多
Stuart Sugito,Sharron Hall,Mohammed S Al-Omary et al.
Stuart Sugito et al.
Midkine (MK) is a heparin-binding growth factor, whose role as a biomarker of coronary artery disease, myocardial ischaemia and necrosis has not been well measured. This study quantified serial MK levels in patients undergoing coronary angi...
LncRNA-LUNAR1 Levels Are Closely Related to Coronary Collaterals in Patients with Chronic Total Coronary Occlusion [0.03%]
LUNAR1长链非编码RNA与慢性完全闭塞冠状动脉患者侧支循环水平密切相关
Wenbin Lu,Zulong Sheng,Ziwei Zhang et al.
Wenbin Lu et al.
Coronary collaterals can effectively improve myocardial blood supply to the area of CTO (chronic total coronary occlusion) and can, thus, reduce infarct size. LUNAR1(leukemia-induced noncoding activator RNA-1) is a specific LncRNA regulated...
Differences in the Interleukin-1β/Soluble ST2 Interplay Between Acute and Chronic Heart Failure [0.03%]
急性心力衰竭与慢性心力衰衰竭中炎性细胞因子白细胞介素-1β/可溶性ST2的相互作用差异分析
E Revuelta-López,J Lupón,A Lax et al.
E Revuelta-López et al.
Recently, novel findings about the interleukin 1β (IL-1 β) axis in acute decompensated heart failure (ADHF) have been published. There is a positive correlation between IL-1 β and interleukin-1 receptor like 1 (sST2) in ADHF patients. Is...
Qiulian Zhou,Yihua Bei
Qiulian Zhou
A Novel In-hospital Congestion Score to Risk Stratify Patients Admitted for Worsening Heart Failure (from ASCEND-HF) [0.03%]
一种新的院内淤血评分系统 用于评估心力衰竭患者的危险性（来自ASCEND-HF研究）
Rajeev Masson,Andrew P Ambrosy,Kevin Kheder et al.
Rajeev Masson et al.
Patients hospitalized for heart failure (HF) remain at high risk for early readmission. A post hoc analysis was performed of the biomarker substudy of the ASCEND-HF trial. An in-hospital congestion score was derived using orthopnea, pedal e...
Lumped-Parameter Circuit Platform for Simulating Typical Cases of Pulmonary Hypertensions from Point of Hemodynamics [0.03%]
基于血流动力学的肺高血压症典型病例 lumped 参数电路仿真平台
Hong Tang,Ziyin Dai,Miao Wang et al.
Hong Tang et al.
Pulmonary hypertension (PH) presents unusual hemodynamic states characterized by abnormal high blood pressure in pulmonary artery. The objective of this study is to simulate how the hemodynamics develops in typical PH cases without treatmen...
Gender-Specific Predictive Markers of Poor Prognosis for Patients with Acute Myocardial Infarction During a 6-Month Follow-up [0.03%]
急性心肌梗死后6个月随访的不良预后性别特异性预测标志物
Ping Wang,Jianhua Yao,Yuan Xie et al.
Ping Wang et al.
Mounting evidence indicates the impact of gender difference on the assessment, treatment, and outcome of patients with acute myocardial infarction (AMI). However, gender-specific prognostic markers of AMI are still lacking. The present stud...