Precision Cardio-Oncology: a Systems-Based Perspective on Cardiotoxicity of Tyrosine Kinase Inhibitors and Immune Checkpoint Inhibitors [0.03%]
基于系统的视角下蛋白酪氨酸激酶抑制剂和免疫检查点抑制剂心血管毒性的精准肿瘤心脏病学
Sherry-Ann Brown,Jordan C Ray,Joerg Herrmann
Sherry-Ann Brown
Cancer therapies have been evolving from conventional chemotherapeutics to targeted agents. This has fulfilled the hope of greater efficacy but unfortunately not of greater safety. In fact, a broad spectrum of toxicities can be seen with ta...
The Role of Cardiac MRI in Animal Models of Cardiotoxicity: Hopes and Challenges [0.03%]
心脏磁共振在心血管毒性动物模型中的作用：希望与挑战
Carolyn J Park,Mary E Branch,Sujethra Vasu et al.
Carolyn J Park et al.
Animal models of chemotherapy-induced cardiotoxicity have been instrumental in understanding the underlying mechanisms of the disease. The use of cardiac magnetic resonance (CMR) imaging and nuclear magnetic resonance (NMR) imaging in precl...
Akash Gupta,Chris Gillett,Patrick Gerard et al.
Akash Gupta et al.
We developed models of pulmonary artery (PA) size in Fontan patients as a function of age and body surface area (BSA) using linear regression and breakpoint analyses based on data from 43 Fontan patients divided into two groups: the extraca...
Sérgio Luiz Borges de Souza,Gustavo Augusto Ferreira Mota,Cristina Schmitt Gregolin et al.
Sérgio Luiz Borges de Souza et al.
Cirrhotic cardiomyopathy is a condition where liver cirrhosis is associated with cardiac dysfunction. Triggers and blockers of cirrhotic cardiomyopathy are poorly understood, which might compromise the prognosis of chronic liver disease pat...
Low Wall Shear Stress Is Associated with Saphenous Vein Graft Stenosis in Patients with Coronary Artery Bypass Grafting [0.03%]
低剪切应力与冠状动脉旁路移植患者股静脉移植物狭窄有关
Muhammad Owais Khan,Justin S Tran,Han Zhu et al.
Muhammad Owais Khan et al.
Biomechanical forces may play a key role in saphenous vein graft (SVG) disease after coronary artery bypass graft (CABG) surgery. Computed tomography angiography (CTA) of 430 post-CABG patients were evaluated and 15 patients were identified...
Diagnostic and Prognostic Value of Coronary Computed Tomography Angiography in Patients with Severe Calcification [0.03%]
冠脉钙化严重的患者冠状动脉CT造影的诊断和预后价值
Belén Díaz-Antón,Jorge Solís,Roberto Díaz Morales et al.
Belén Díaz-Antón et al.
Our aim was to analyze its diagnostic and prognostic value in patients with high coronary calcium score (CCS). A total of 113 patients with CCS > 400 were included. Significant coronary artery disease (CAD) was defined as stenosis ≥ 50%. I...
Exendin-4 Protects Against Myocardial Ischemia-Reperfusion Injury by Upregulation of SIRT1 and SIRT3 and Activation of AMPK [0.03%]
exendin-4通过上调sirt1和sirt3及激活ampk对抗心肌缺血再灌注损伤
Refaat A Eid,Mashael Mohammed Bin-Meferij,Attalla Farag El-Kott et al.
Refaat A Eid et al.
This study evaluated if the cardioprotective effect of Exendin-4 against ischemia/reperfusion (I/R) injury in male rats involves modulation of AMPK and sirtuins. Adult male rats were divided into sham, sham + Exendin-4, I/R, I/R + Exendin-4...
Effects of Estrogen on Cardiac mRNA and LncRNA Expression Profiles in Hypertensive Mice [0.03%]
雌激素对高血压小鼠心脏mRNA和lncRNA表达谱的影响分析
Jingkang Zhu,Huan Wang,Hui Chen
Jingkang Zhu
Estrogen is a vascular protection factor and plays a protective role in the pathogenesis of gender differences in cardiovascular diseases. This study was to address the possible mechanisms that may explain the relationship between estradiol...
The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease [0.03%]
心脏疾病免疫治疗中的CD40-CD40L对子研究
Laura A Bosmans,Lena Bosch,Pascal J H Kusters et al.
Laura A Bosmans et al.
Chronic inflammation drives the development of atherosclerosis. Despite optimal treatment of classical cardiovascular risk factors, a substantial portion of the population has elevated inflammatory biomarkers and develops atherosclerosis-re...
Correction to: MGUS Predicts Worse Prognosis in Patients with CoronaryArtery Disease [0.03%]
对MGUS预测冠状动脉疾病患者预后较差的影响的修正意见
Zhao Xu,Yifeng Sun,Tianhong Xu et al.
Zhao Xu et al.
The captions to Figures 1-4 in this article as originally published were mismatched with the figures themselves.