Increased Expression of Inactive Rhomboid Protein 2 in Circulating Monocytes after Acute Myocardial Infarction [0.03%]
急性心肌梗死后循环单核细胞中无效蛋白2的表达增加
Phillip van Dijck,Carmen Hannemann,Henryk Dreger et al.
Phillip van Dijck et al.
Increased TNF-α levels following acute myocardial infarction (AMI) contribute to impaired recovery of myocardial function. Interaction of inactive rhomboid protein 2 (iRhom2) with TNF-α converting enzyme (TACE) is required for TNF-α shed...
Isolated Perfused Hearts for Cardiovascular Research: An Old Dog with New Tricks [0.03%]
离体灌注心脏在心血管研究中的应用：老技术的新用途
Tianshuo Yang,Zirui Liu,Songren Shu et al.
Tianshuo Yang et al.
In modern cardiovascular research, isolated perfused hearts have become cost-effective and highly reproducible tools to investigate the mechanisms of cardiovascular diseases (CVDs). Since they were first introduced in the nineteenth century...
The activation of P38MAPK Signaling Pathway Impedes the Delivery of the Cx43 to the Intercalated Discs During Cardiac Ischemia-Reperfusion Injury [0.03%]
缺血再灌注损伤时活化P38MAPK信号通路阻碍心肌细胞间缝隙连接蛋白43的交换与传递
Xiang Huang,Xue Bai,Jing Yi et al.
Xiang Huang et al.
Ischemic heart disease is caused by coronary artery occlusion. Despite the increasing number and success of interventions for restoring coronary artery perfusion, myocardial ischemia-reperfusion (I/R) injury remains a significant cause of m...
Predictive Value of 5-Methoxytryptophan on Long-Term Clinical Outcome after PCI in Patients with Acute Myocardial Infarction-a Prospective Cohort Study [0.03%]
急性心肌梗死患者PCI术后5-羟色胺代谢产物对长期临床预后的预测价值：前瞻性队列研究
Kui Huang,Xiao-Qin Wen,Wei Zhang et al.
Kui Huang et al.
Background: In recent years, 5-Methoxytryptophan (5-MTP) has been identified as an endothelial factor with vaso-protective and anti-inflammatory properties. ...
Polygenic Risk Score Assessment for Coronary Artery Disease in Asian Indians [0.03%]
南亚印度人冠状动脉疾病多基因风险评分的评估
Madhusmita Rout,Gurleen Kaur Tung,Jai Rup Singh et al.
Madhusmita Rout et al.
We evaluated the performance of various polygenic risk score (PRS) models derived from European (EU), South Asian (SA), and Punjabi Asian Indians (AI) studies on 13,974 subjects from AI ancestry. While all models successfully predicted Coro...
RyR2 Stabilizer Attenuates Cardiac Hypertrophy by Downregulating TNF-α/NF-κB/NLRP3 Signaling Pathway through Inhibiting Calcineurin [0.03%]
RyR2稳定剂通过抑制钙调神经磷酸酶下调TNF-α/NF-κB/NLRP3信号通路缓解心室肥厚
Yi Gao,Shuai Li,Xueyan Liu et al.
Yi Gao et al.
The effect of Ryanodine receptor2 (RyR2) and its stabilizer on cardiac hypertrophy is not well known. C57/BL6 mice underwent transverse aortic contraction (TAC) or sham surgery were administered dantrolene, the RyR2 stabilizer, or control d...
Yi-Xi Chen,An-Ran Zhao,Tian-Wen Wei et al.
Yi-Xi Chen et al.
Heart failure and myocardial infarction, global health concerns, stem from limited cardiac regeneration post-injury. Myocardial infarction, typically caused by coronary artery blockage, leads to cardiac muscle cell damage, progressing to he...
LMNA p.Arg624His Variant Reduces Lamin Expression at mRNA Level: Elucidating Molecular Pathways toward Cardiac Involvement in Laminopathies [0.03%]
LMNA基因p.Arg624His变异通过降低信使核糖核酸(mRNA)水平而减少lamin表达：阐明laminopathy患者心脏受累的分子途径
Isabel Jimenez-Alcantara,Estefania Lozano-Velasco,Sheila Caño-Carrillo et al.
Isabel Jimenez-Alcantara et al.
Cristina Barbero,Andrea Costamagna,Peter Verbrugghe et al.
Cristina Barbero et al.
Aim of this study was to compare redo MV surgery patients undergoing right mini-thoracotomy and EAC with redo MV patients undergoing surgery through other approaches. Redo MV patients from 7 European centers were analyzed. Primary endpoint ...
Correction: TJ-M2010-5 Attenuates Severe Myocardial Ischemia/Reperfusion Injury in Heart Transplantation by Inhibiting MyD88 Homodimerization In Vivo [0.03%]
纠正：TJ-M2010-5通过抑制MyD88二聚化在心脏移植中减轻严重的心肌缺血再灌注损伤
Huifang Yang,Ping Zhou,Qingwen Li et al.
Huifang Yang et al.