CRISPR/Cas9 Mediated Deletion of the Uox Gene Generates a Mouse Model of Hyperuricemia with Multiple Complications [0.03%]
利用CRISPR/Cas9技术敲除尿酸氧化酶基因构建出具有多种合并症的高尿酸血症小鼠模型
Linzi Zeng,Shalaimaiti Shali,Yabiao Gao et al.
Linzi Zeng et al.
Hyperuricemia is a common metabolic disorder with severe complications. We aimed to develop a mouse model for spontaneous hyperuricemia. Uox-/- mouse model was generated on C57BL/6J background by deleting exon 2-4 of Uox using the CRISPR/Ca...
Novel Genetic Variants Associated with Primary Myocardial Fibrosis in Sudden Cardiac Death Victims [0.03%]
突发性心脏骤停受害者中新发的一型心肌纤维化相关基因变异
Sini Skarp,Anne Doedens,Lauri Holmström et al.
Sini Skarp et al.
Myocardial fibrosis is a common finding in victims of sudden cardiac death (SCD). Whole exome sequencing was performed in 127 victims of SCD with primary myocardial fibrosis as the only pathological finding. These cases are derived from the...
Mitochondria-Associated Organelle Crosstalk in Myocardial Ischemia/Reperfusion Injury [0.03%]
缺血/再灌注损伤中心肌线粒体相关器官的相互作用
Hui Yao,Yuxin Xie,Chaoquan Li et al.
Hui Yao et al.
Organelle damage is a significant contributor to myocardial ischemia/reperfusion (I/R) injury. This damage often leads to disruption of endoplasmic reticulum protein regulatory programs and dysfunction of mitochondrial energy metabolism. Mi...
Extracellular Vesicles to Predict Outcomes After Transcatheter Aortic Valve Implantation - a Prospective, Multicenter Cohort Study [0.03%]
外泌体预测经导管主动脉瓣植入术后预后的前瞻性多中心队列研究
Radosław Wilimski,Jan Budzianowski,Michał Łomiak et al.
Radosław Wilimski et al.
Introduction: Transcatheter aortic valve implantation (TAVI) is an established treatment for aortic stenosis (AS) in patients at intermediate and high surgical risk. Circulating extracellular vesicles (EVs) are nanopartic...
Qin Hou,Siyu Ouyang,Zhongcheng Xie et al.
Qin Hou et al.
Exosomes, nano-sized small extracellular vesicles, have been shown to serve as mediators between intercellular communications by transferring bioactive molecules, such as non-coding RNA, proteins, and lipids from secretory to recipient cell...
The Genetic Factors Influencing Cardiomyopathies and Heart Failure across the Allele Frequency Spectrum [0.03%]
全等位基因频率范围内心肌病和心力衰竭的遗传因素分析
Srinjay Mukhopadhyay,Prithvi Dixit,Najiyah Khanom et al.
Srinjay Mukhopadhyay et al.
Heart failure (HF) remains a major cause of mortality and morbidity worldwide. Understanding the genetic basis of HF allows for the development of disease-modifying therapies, more appropriate risk stratification, and personalised managemen...
Pathogenic Autoimmunity in Atherosclerosis Evolves from HSP60-Reactive CD4 + T Cells [0.03%]
热休克蛋白HSP60反应性CD4⁺T淋巴细胞导致动脉粥样硬化自身免疫病的发展
Shixiang Wang,Yongquan Chen,Danyan Zhou et al.
Shixiang Wang et al.
Clinical evidence suggests anti-Hsp60 antibodies could contribute to atherosclerosis (AS) development, with unclear mechanisms. This study aims to explore the role of anti-HSP60-mediated autoimmunity in AS progression. HSP60-MHC tetramers w...
Differential Effects of Pharmacologic and Mechanical Support on Right-Left Ventricular Coupling [0.03%]
药物支持和机械支持对左右心室耦合的不同影响
Kimberly K Lamberti,Efrat M Goffer,Elazer R Edelman et al.
Kimberly K Lamberti et al.
Background: Percutaneous ventricular assist devices are increasingly relied on to maintain perfusion for cardiogenic shock patients. Optimal medical management strategies however remain uncertain from limited understandin...
Lei Liao,Tong Wang,Lu Zhang et al.
Lei Liao et al.
Ischemic heart disease (IHD) is a common clinical cardiovascular disease with high morbidity and mortality. Sodium glucose cotransporter protein inhibitor (SGLTi) is a novel hypoglycemic drug. To date, both clinical trials and animal experi...
A Novel Swine Model for Inducing Functional Tricuspid Valve Regurgitation [0.03%]
一种新的用于诱导功能性三尖瓣反流的猪模型
Dawei Lin,Peng Zhang,Yongchao Zhao et al.
Dawei Lin et al.
Functional tricuspid regurgitation (FTR) is the most common TR, although experimental models to effectively study it are scarce; therefore, this study aimed to establish a robust experimental swine model. A swine FTR model was developed usi...