Silencing DOCK2 Attenuates Cardiac Fibrosis Following Myocardial Infarction in Mice Via Targeting PI3K/Akt and Wnt/β-Catenin Pathways [0.03%]
DOCK2沉默通过靶向PI3K/Akt和Wnt/β-catenin信号通路减轻小鼠心肌梗死后的心脏纤维化
Guangquan Hu,Jin Chen,Min Chen et al.
Guangquan Hu et al.
Cardiac fibrosis following myocardial infarction (MI) seriously affects the prognosis and survival rate of patients. This study aimed to determine the effect and regulation mechanism of the dedicator of cytokinesis 2 (DOCK2) during this pro...
Morphological Features of the Vertebrobasilar System Predict Ischemic Stroke Risk in Spontaneous Vertebral Artery Dissection [0.03%]
血管形态学特征预测椎动脉夹层的缺血性卒中风险
Jiajia Bao,Mateng Bai,Muke Zhou et al.
Jiajia Bao et al.
The vertebral artery's morphological characteristics are crucial in spontaneous vertebral artery dissection (sVAD). We aimed to investigate morphologic features related to ischemic stroke (IS) and develop a novel prediction model. Out of 12...
Circulating circ_0069094 is Correlated with the Present and Endothelial Injury of Acute Coronary Syndrome [0.03%]
circRNA circ_0069094与急性冠脉综合征现症及内皮损伤的相关性研究
Zhen Gao,Peng Wu,Hezhong Zhu et al.
Zhen Gao et al.
To investigate the impacts of circ_0069094 on acute coronary syndrome. Real-time polymerase chain reaction was used to detect the expression levels of circ_0069094, and its diagnostic performance was evaluated using ROC curve. Spearman's me...
TMAO Impairs Mouse Aortic Vasodilation by Inhibiting TRPV4 Channels in Endothelial Cells [0.03%]
TMAO通过抑制内皮细胞中TRPV4通道损伤小鼠主动脉血管舒张功能
Ning Zhang,Liangju Liu,Xiaowang Lv et al.
Ning Zhang et al.
Trimethylamine oxide (TMAO) is an intestinal flora metabolite associated with risk of cardiovascular diseases. Transient receptor potential vanilloid 4 (TRPV4) is a Ca2+-permeable ion channel that is essential for vasodilation and endotheli...
Plasma Biomarker Screening Based on Proteomic Signature of Patients with Resistant Hypertension [0.03%]
基于难治性高血压患者蛋白质组特征的血浆生物标志物筛选研究
Jianmin Du,Xiaoqian Yu,Wenyu Zhang et al.
Jianmin Du et al.
Resistant hypertension (RH) poses a significant health challenge, yet its underlying pathogenesis remains unclear. This study employs untargeted proteomic techniques to analyze the plasma of patients with RH and controlled hypertension (CH)...
High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation [0.03%]
高强度聚焦超声技术——肺动脉去神经化治疗新选择
Yonghui Xie,Taoyue Yao,Xiaogang Zhu et al.
Yonghui Xie et al.
This research aimed to explore whether high-intensity focused ultrasound (HIFU) could conduct pulmonary artery denervation (PADN). HIFU was performed in pulmonary arteries of 6 normotensive rabbits at dose of 250W, 6 times for each rabbit, ...
Blood Pressure Variability After Non-invasive Low-level Tragus Stimulation in Acute Heart Failure [0.03%]
非侵入性低强度耳屏刺激对急性心力衰竭患者血压变异性的影响
Michiaki Nagai,Keigo Dote,Masaya Kato et al.
Michiaki Nagai et al.
Higher blood pressure (BP) variability (BPV) was shown to be strong predictors of poor cardiovascular outcomes in heart failure (HF). It is currently unknown if low-level tragus stimulation (LLTS) would lead to improvement in BPV in acute H...
Gut Microbiota as Predictive Biomarker for Chronic Heart Failure in Patients with Different Nutritional Risk [0.03%]
不同营养风险慢性心力衰竭患者肠道菌群的预测标志物作用
Chen Yang,Xiaopeng Li,Miaomiao Hu et al.
Chen Yang et al.
To examine the relationship between gut microbiota and disease development in chronic heart failure patients with different nutritional risk. The study analyzed stool samples from 62 CHF patients and 21 healthy peoples using 16S rRNA gene s...
Vaccarin Ameliorates Doxorubicin-Induced Cardiotoxicity via Inhibition of p38 MAPK Mediated Mitochondrial Dysfunction [0.03%]
通过抑制p38MAPK介导的线粒体功能障碍，Vacarrin改善阿霉素引起的心脏毒性
Xin Shi,Yang Cao,Hongyu Wang et al.
Xin Shi et al.
Doxorubicin is a frequently used chemotherapeutic agent for treating various malignancies. However, it leads to severe cardiotoxic side effects, such as heart failure, and elevates the risk of sudden cardiac death among cancer patients. Whi...
Modulating the Expression of Exercise-induced lncRNAs: Implications for Cardiovascular Disease Progression [0.03%]
调控运动诱导的长链非编码RNA表达：对心血管疾病进展的影响
Li-Hua Yu,Ge-Lin Zhang
Li-Hua Yu
Recent research shows exercise is good for heart health, emphasizing the importance of physical activity. Sedentary behavior increases the risk of cardiovascular disease, while exercise can help prevent and treat it. Additionally, physical ...