Targeting Lactic Acid Modification in Ischemic Heart Diseases: Novel Therapeutics and Mechanism [0.03%]
缺血性心脏病中乳酸修饰的作用及机制研究及新型治疗策略探索
Tangjiang Wan,Yucheng Liang,Tianwen Wei et al.
Tangjiang Wan et al.
Ischemic heart disease (IHD), especially acute myocardial infarction (AMI), has a high mortality rate and poses a great threat to human health. When myocardial infarction occurs, the structure and function of the myocardium are significantl...
Husam M Salah,Adrian Ebner,Ravi N Srinivasa et al.
Husam M Salah et al.
Lymphatic dysfunction contributes to congestion and end-organ damage in heart failure (HF), yet current therapies do not directly target lymphatic congestion. Thoracic duct (TD) drainage offers a novel approach to address this gap. This mul...
Targeting KDM4C Prevents Heart Failure after Acute Myocardial Infarction Via Activation of SOS2 [0.03%]
靶向KDM4C通过激活SOS2防止急性心肌梗死后的心力衰竭
Caiping Tan,Xiaoqi Chen,Lingqi Xu et al.
Caiping Tan et al.
Here, we focused on the function of SOS2 in heart failure (HF) after acute myocardial infarction (AMI) and investigated the mechanism. An oxygen-glucose deprivation (OGD) model in HL-1 cardiomyocytes and the ligation of the left anterior de...
The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy [0.03%]
铁死亡和自噬在心肌缺血再灌注损伤中的联系：治疗新方向
Xiaoting Yang,Hui Wu,Di Liu et al.
Xiaoting Yang et al.
Myocardial ischemia/reperfusion (I/R)-induced cell death, such as autophagy and ferroptosis, is a major contributor to cardiac injury. Regulating cell death may be key to mitigating myocardial ischemia/reperfusion injury (MI/RI). Autophagy ...
Rupak Mukherjee,Enrique Lara-Pezzi
Rupak Mukherjee
Mitochondrial Dysfunction in HFpEF: Potential Interventions Through Exercise [0.03%]
射血分数保留的心力衰竭中的线粒体功能障碍：运动干预的潜在作用
Xinxin Cui,Michail Spanos,Cuimei Zhao et al.
Xinxin Cui et al.
HFpEF is a prevalent and complex type of heart failure. The concurrent presence of conditions such as obesity, hypertension, hyperglycemia, and hyperlipidemia significantly increase the risk of developing HFpEF. Mitochondria, often referred...
Class III Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 in Cardiovascular Health and Disease [0.03%]
III类磷脂酰肌醇3-激酶/酸性囊泡蛋白分选34在心血管健康与疾病中的作用
Yuanjun Shen,Jason P Gleghorn
Yuanjun Shen
Phosphatidylinositol-3 kinases (PI3Ks) play a critical role in maintaining cardiovascular health and the development of cardiovascular diseases (CVDs). Specifically, vacuolar Protein Sorting 34 (VPS34) or PIK3C3, the only member of Class II...
Chitinase-3-like Protein 1 Reduces the Stability of Atherosclerotic Plaque via Impairing Macrophagic Efferocytosis [0.03%]
软骨寡聚基质蛋白通过干扰巨噬细胞的胞葬作用降低动脉粥样硬化斑块稳定性
Yandong Liu,Weilin Hu,Futang Yang et al.
Yandong Liu et al.
CHI3L1 is strongly associated with atherosclerosis, but its role in macrophages remains unknown. In this study, we observed a significant up-regulation of CHI3L1 in both carotid plaques and serum of symptomatic patients, and demonstrated th...
p16INK4a Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance [0.03%]
p16INK4a通过抑制PI3K/AKT信号通路并诱导氧化应激加重脓毒症相关的心脏损伤
Baihong Li,Kai Wang,Xiaoyan Wang et al.
Baihong Li et al.
Severe sepsis can promote myocardial injury and cardiac dysfunction, but role of p16 in sepsis-induced myocardial injury remains undefined. PBMCs were collected from patients. Expression of inflammatory factors and NLRP3 pathway were detect...
CRISPR-Cas9 Targeting PCSK9: A Promising Therapeutic Approach for Atherosclerosis [0.03%]
针对PCSK9的CRISPR-Cas9技术在动脉粥样硬化治疗中的应用前景
Bin Gu,Min Li,Dan Li et al.
Bin Gu et al.
CRISPR-Cas9 gene editing technology, as an innovative biomedical tool, holds significant potential in the prevention and treatment of atherosclerosis. By precisely editing key genes such as PCSK9, CRISPR-Cas9 offers the possibility of long-...