Randomised Comparison of Culotte- versus Double Kissing Crush Stenting in de novo non-left Main Coronary Bifurcation Lesions: Rationale and Design of the Bifurcation Bad Krozingen trial-3 (BBK-3) [0.03%]
关于原发性非左主冠状动脉分叉病变的 culotte 和双面对吻 crush 成形术的随机对照研究：Bifurcation Bad Krozingen 试验-3 的立题依据与设计要点
Faridun Rahimi,Nikolaus Löffelhardt,Jan Minners et al.
Faridun Rahimi et al.
Whether culotte or double kissing (DK)-crush stenting is the superior systematic 2-stent technique in non-left main bifurcation lesions is unclear. The BBK-3 (unique identifier NCT04192760) is a multicenter, prospective, randomized controll...
A Novel Angiography-Derived Computational Coronary Flow Reserve to Evaluate Non-Obstructive Coronary Artery Disease [0.03%]
一种新的基于导管冠状动脉造影的计算性冠脉血流储备方法用于评价非阻塞性冠心病
Jingpu Wang,Yumeng Hu,Xinyi Yang et al.
Jingpu Wang et al.
Coronary flow reserve (CFR) is a key parameter for risk stratification in coronary artery disease but is limited by high cost, prolonged procedure time, and suboptimal reproducibility. We proposed a novel angiography-based method (Angio-CFR...
Validity and Reproducibility of the Six-Minute Stepper Test in Cardiac Patients [0.03%]
心脏病人六分钟踏步试验的有效性和可重复性研究
Michaël Racodon,Claudine Fabre,Pierre Vanhove et al.
Michaël Racodon et al.
The Six-Minute Walk Test (6MWT) traditionally assesses exercise capacity in cardiac patients but requires a large space. The Six-Minute Stepper Test (6MST) has been validated as an alternative in various populations. This study evaluates th...
LACC1 Enhances Polyamine Immunometabolism in Inflammatory Macrophages to Inhibit Atherosclerosis Progression [0.03%]
LACC1通过增强炎症巨噬细胞中的多胺免疫代谢来抑制动脉粥样硬化进展
Jingyong Zhang,Yuan Xu,Zonglin Han et al.
Jingyong Zhang et al.
To explore the function and potential mechanism of laccase domain-containing 1 (LACC1) on atherosclerosis (AS). ApoE-/- mice feed with high-fat diet (HFD) were injected with adenovirus shLACC1 (Ad-shLACC1) or Ad-shNC via tail vein. LACC1 wa...
Study of The Relationship Between Differential Small Molecule Peptides in Peripheral Blood and Arteriosclerosis in Patients with Essential Hypertension [0.03%]
高血压患者外周血差异性小分子肽与动脉粥样硬化关系的研究
Yunfeng Fang,Jingwen Yue,Min Zhang et al.
Yunfeng Fang et al.
This study investigated the association between serum small peptides and arteriosclerosis (AS) in hypertensive patients. Sixty hypertensive patients (with and without AS) and 30 healthy individuals were enrolled. Untargeted metabolomics ide...
Fracture and Fragmentation of Vascular Calcifications by Focused Ultrasound [0.03%]
聚焦超声波对血管钙化灶的震碎和消融
Lucas Su Chen,Gabriel Koh,Yak-Nam Wang et al.
Lucas Su Chen et al.
Peripheral artery disease results in ischemia necessitating interventions such as balloon angioplasty. However, calcified lesions resist balloon and stent expansion, leading to poor outcomes. We hypothesized that focused ultrasound can frac...
Inhibition of VSMC Ferroptosis Mitigates Pathological Vascular Remodeling: A Novel Therapeutic Strategy for Abdominal Aortic Aneurysm [0.03%]
血管平滑肌细胞铁死亡抑制缓解病理性血管重构：腹主动脉瘤治疗新策略
Yating Zhou,Yanyu Chen,Yuting Cui et al.
Yating Zhou et al.
Ferroptosis plays a key role in abdominal aortic aneurysm (AAA) development. This study explores whether and how ferroptosis regulates AAA progression. Ferroptosis was confirmed in human AAA tissue. In vitro experiments with primary mouse v...
A Metabolic Signature Specific to the Patients with Type 2 Diabetes and its Association with the Pathogenesis of Diabetic-Foot Syndrome [0.03%]
2型糖尿病患者特有的代谢标志及其与糖尿病足综合征发病机制的相关性研究
Tao Wang,Ziyu Su,Ming Zhong et al.
Tao Wang et al.
Oxidative stress and protein nonenzymatic glycation are key factors in diabetic-foot syndrome pathogenesis. Type 2 diabetes (T2DM) progression involves excessive gluconolactone (GDL) production, linked to endothelial injury and diabetic art...
Comprehensive Plasma Proteomic Profiling Reveals Differentially Regulated Signaling Pathways Underlying Left Ventricular Hypertrophy Between Hypertrophic Cardiomyopathy and Aortic Stenosis [0.03%]
全面的血浆蛋白质组分析发现了肥厚型心肌病和主动脉瓣狭窄所致左心室肥厚的信号通路的差异性调节
Heidi S Lumish,Lorenzo R Sewanan,Lusha W Liang et al.
Heidi S Lumish et al.
Hypertrophic cardiomyopathy (HCM) is the most common genetic myocardial disease, characterized by asymmetric left ventricular hypertrophy (LVH) due to sarcomeric mutations. Aortic stenosis (AS) results in concentric LVH, due to pressure ove...
Gaowei Yang,Yiming Wang,Junfang Guo et al.
Gaowei Yang et al.
Stress granules (SGs) are membrane-less cytoplasmic assemblies composed of mRNAs and RNA-binding proteins (RBPs) that transiently form to cope with various cellular stressors by halting mRNA translation and, consequently, protein synthesis....