Induced Human-like Coronary Stenosis in Hypercholesterolemic PCSK9 Minipigs [0.03%]
高胆固醇PCSK9小型猪中诱导的人工冠状动脉狭窄
Jacob Nicolaisen,Christian Frøsig Bo Poulsen,Martin Mæng Bjørklund et al.
Jacob Nicolaisen et al.
Translational models for obstructive coronary artery disease are lacking. We aimed to develop a porcine model for obstructive coronary stenosis induced by bioresorbable stent (BRS) implantation in hypercholesterolemic proprotein convertase ...
PLK1 Downregulation Attenuates ET-1-Induced Cardiomyocyte Hypertrophy by Suppressing the ERK1/2 Pathway [0.03%]
PLK1下调通过抑制ERK1/2通路减弱ET-1诱导的心肌细胞肥大
Jie Ding,Anqi Yang,Liping Zhou et al.
Jie Ding et al.
Cardiomyocyte hypertrophy is a key remodeling response to cardiac stress and an independent risk factor for heart failure. However, the molecular mechanism of cardiomyocyte hypertrophy is not yet fully understood. We here found Polo-like ki...
Inhibition of Egr2 Protects against TAC-induced Heart Failure in Mice by Suppressing Inflammation and Apoptosis Via Targeting Acot1 in Cardiomyocytes [0.03%]
通过靶向心肌细胞中的Acot1抑制Egr2可保护小鼠免受TAC诱导的心力衰竭，途径是抑制炎症和凋亡
Xiaolu Hou,Guoling Hu,Heling Wang et al.
Xiaolu Hou et al.
Heart failure (HF) is a clinical syndrome caused by structural or functional abnormalities in heart. Egr2 has been reported to be protective for multiple diseases, but its effect on HF remains unknown. The present study intended to investig...
Human Cardiac Microtissues Display Improved Engraftment and Survival in a Porcine Model of Myocardial Infarction [0.03%]
猪心肌梗塞模型显示人源心脏微组织具有更好的移植物存活率
Evelyne Demkes,Aina Cervera-Barea,Patricia Ebner-Peking et al.
Evelyne Demkes et al.
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) constitute a promising therapy for myocardial infarction (MI). The lack of an effective immunosuppressive regimen, combined with single-cell transplantations, results in...
RNA Therapies in Cardio-Kidney-Metabolic Syndrome: Advancing Disease Management [0.03%]
RNA疗法在心肾代谢综合征中的应用：推进疾病管理
Abbas Mohammadi,Azin Karimian,Kasra Shokri et al.
Abbas Mohammadi et al.
Cardio-Kidney-Metabolic (CKM) Syndrome involves metabolic, kidney, and cardiovascular dysfunction, disproportionately affecting disadvantaged groups. Its staging (0-4) highlights the importance of early intervention. While current managemen...
A Novel Dual Latex Balloon Catheter for Temporarily Closing Acute Postinfarction Ventricle Septum Defect (VSD) in a Pig Model [0.03%]
一种新型双乳胶气球导管用于猪急性心肌梗死室间隔缺损(VSD)的临时闭合
Hua-Di Qin,Yang Yang,Fei Xie et al.
Hua-Di Qin et al.
Acute postinfarction ventricular septum defect has a persistently high mortality rate due to unstable scars in the acute phase, which make surgery or occluder use unsuitable. Delayed closure increases the risk of irreversible hemodynamic de...
New Types of Post-Translational Modification of Proteins in Cardiovascular Diseases [0.03%]
心血管疾病中蛋白质新的修饰类型
Juntao Fang,Shaoyu Wu,Hengli Zhao et al.
Juntao Fang et al.
Post-translational modifications (PTMs), which are covalent alterations of proteins after their synthesis, are critical for their proper function and the maintenance of cellular physiology. The significance of PTMs in the context of cardiov...
Resonance Raman Spectroscopy Detects Ischemia in Experimental Coarctation of the Aorta in a Rodent Model [0.03%]
共振拉曼光谱在啮齿类动物模型中检测主动脉缩窄的缺血情况
Alyssa R Thomas,Kristen Lazelle,Julia Garcia Mancebo et al.
Alyssa R Thomas et al.
Coarctation of the aorta (CoA) can cause aortic obstruction, ischemia, and death. Resonance Raman Spectroscopy (RRS) measures tissue oxyhemoglobin (ShbO2) and mitochondrial redox state (3RMR) non-invasively. Metal wire was placed around the...
Apelin13 Loaded Nano-Niosomes Confer Cardioprotection in a Rat Model of Myocardial Ischemia Reperfusion by Targeting the Nrf2/HO-1 Pathway [0.03%]
载有Apelin13的纳米诺软胶囊通过靶向Nrf2/HO-1通路在心肌缺血再灌注大鼠模型中发挥心脏保护作用
Neda Tekiyeh Maroof,Saeed Mehrzadi,Maryam Naseroleslami et al.
Neda Tekiyeh Maroof et al.
Although apelin-13 has cardioprotective impact, its short half-life in the bloodstream has challenged its clinical application. Using nanocarriers can increase the bioavailability, functionality, and stability of drugs. Current investigatio...
Sensitivity of Left Atrial Flow Dynamics to Echocardiographic and Computed Tomography Data [0.03%]
左心房血流动力学对超声心动图和计算机断层扫描数据的敏感性
Ahmad Bshennaty,Brennan J Vogl,Ghasaq Saleh et al.
Ahmad Bshennaty et al.
Computational simulations are a powerful tool in the understanding, diagnosing, and treatment of cardiovascular diseases. Incomplete clinical data often limits computational assessment, which may lead to inaccuracies. This study aims to ass...