Comprehensive Plasma Proteomic Profiling Reveals Differentially Regulated Signaling Pathways Underlying Left Ventricular Hypertrophy Between Hypertrophic Cardiomyopathy and Aortic Stenosis [0.03%]
全面的血浆蛋白质组分析发现了肥厚型心肌病和主动脉瓣狭窄所致左心室肥厚的信号通路的差异性调节
Heidi S Lumish,Lorenzo R Sewanan,Lusha W Liang et al.
Heidi S Lumish et al.
Hypertrophic cardiomyopathy (HCM) is the most common genetic myocardial disease, characterized by asymmetric left ventricular hypertrophy (LVH) due to sarcomeric mutations. Aortic stenosis (AS) results in concentric LVH, due to pressure ove...
Gaowei Yang,Yiming Wang,Junfang Guo et al.
Gaowei Yang et al.
Stress granules (SGs) are membrane-less cytoplasmic assemblies composed of mRNAs and RNA-binding proteins (RBPs) that transiently form to cope with various cellular stressors by halting mRNA translation and, consequently, protein synthesis....
Glycerophospholipid and Sphingosine- 1-phosphate Metabolism in Cardiovascular Disease: Mechanisms and Therapeutic Potential [0.03%]
心血管疾病的甘油磷脂和鞘氨醇-1-磷酸代谢：机制及治疗潜力
Huiru Tang,Chengxia Kan,Kexin Zhang et al.
Huiru Tang et al.
Cardiovascular disease remains a leading cause of mortality worldwide, driven by factors such as dysregulated lipid metabolism, oxidative stress, and inflammation. Recent studies highlight the critical roles of both glycerophospholipid and ...
Nanotechnology Innovations in Myocardial Infarction: Diagnosis, Treatment and the Way Forward [0.03%]
纳米技术在心肌梗死诊断和治疗中的创新及未来展望
Wenhai Wang,Dexin Xu,Jian Ding et al.
Wenhai Wang et al.
Myocardial infarction (MI) is a global health concern that necessitates continued advancements in diagnostic and therapeutic modalities. Nanotechnology facilitates prompt diagnosis and personalized treatment. This manuscript explicitly revi...
The Impact of Opioids on Epigenetic Modulation in Myocardial Ischemia and Reperfusion Injury: Focus on Non-coding RNAs [0.03%]
阿片类药物对心肌缺血再灌注损伤表观遗传调控影响的研究进展：非编码RNA的视角
Mohsen Davari,Mahmoud Khansari,Sahar Hosseini et al.
Mohsen Davari et al.
Myocardial ischemia-reperfusion injury (IRI) is a major issue in cardiovascular medicine, marked by tissue damage from the restoration of blood flow after ischemia. Opioids, known for their pain-relieving properties, have emerged as potenti...
Association Between Magnesium Depletion Score and Peripheral Artery Disease in Middle-Aged and Older Population [0.03%]
镁缺乏评分与中老年人群周围动脉疾病的关系
Zongao Cai,Jiachen She
Zongao Cai
The magnesium depletion score (MDS) is considered a new valuable predictor of body magnesium status. This study aimed to explore the association between MDS and PAD among participants aged ≥ 40 years on the National Health and Nutrition Ex...
IL-22 Attenuates Pressure Overload-Induced Heart Failure and Inflammation [0.03%]
白细胞介素22通过减轻炎症反应抑制压力超载诱导的心脏重塑和心力衰竭
Lanqing Xiang,Guoqing Yin,Zifan Gong et al.
Lanqing Xiang et al.
Heart failure (HF) due to left ventricular (LV) dysfunction remains a major global health challenge, with inflammation driving its progression under chronic pressure overload, such as hypertension. This study explored the role of interleuki...
Mesenchymal Stem Cell-based Apelin Gene Therapy Improves Pulmonary Artery Remodeling in Monocrotaline-induced Pulmonary Hypertension Through PI3K/AKT/eNOS and ERK1/2 Signaling Pathways [0.03%]
基于间充质干细胞的阿皮林基因治疗通过PI3K/AKT/eNOS和ERK1/2信号传导途径改善毛花洋地黄诱导的肺动脉高血压中的肺动脉重建
Li Wang,Weijian Wang,Ting Wu et al.
Li Wang et al.
Pulmonary arterial hypertension (PAH) poses a challenge due to limited curative options and ineffective treatments. Mesenchymal stem cell (MSC) therapy has emerged as a potential intervention for PAH. This study delved into the therapeutic ...
The Role of Mitophagy in Cardiac Metabolic Remodeling of Heart Failure: Insights of Molecular Mechanisms and Therapeutic Prospects [0.03%]
心力衰竭心脏代谢重塑中线粒体自噬的作用：分子机制的见解和治疗前景
Fangying Yan,Liwen Bao
Fangying Yan
Heart failure (HF) treatment remains one of the major challenges in cardiovascular disease management, and its pathogenesis requires further exploration. Cardiac metabolic remodeling is of great significance as a key pathological process in...
Ting Liu,Ding Ai
Ting Liu
Lipoxygenases (LOXs) are a family of dioxygenases that catalyze the peroxidation of polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, initiating the synthesis of bioactive lipid mediators. The LOX-mediated production ...