Correction: The SGLT2 Inhibitor Canagliflozin Reduces Atherosclerosis by Enhancing Macrophage Autophagy [0.03%]
correction：钠-葡萄糖协同转运蛋白2抑制剂卡格列净通过增强巨噬细胞自噬减少动脉粥样硬化
Hongping Chen,Da Teng,Bowen Xu et al.
Hongping Chen et al.
PFKFB3 Promotes Myofibroblast Differentiation and Cardiac Fibrosis Through its Intra- and Extra- Cellular Roles [0.03%]
PKFB3通过细胞内和细胞外作用促进肌成纤维细胞分化和心脏纤维化
Bing Han,Zhaowei Zhu,Yongxiang Wang et al.
Bing Han et al.
Cardiac fibrosis remains a major clinical challenge with limited therapeutic options, and the role of PFKFB3 in its pathogenesis remains unclear. Single-cell RNA sequencing analysis was applied and the results demonstrated that glycolysis w...
Frederik E Deiman,Myrthe M de Graaf,Herman H W Sillje et al.
Frederik E Deiman et al.
RNA-based therapeutics, such as small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs) and messenger RNAs (mRNAs) are promising therapeutics that offer new avenues for targeting molecular pathways underlying heart failure (HF) p...
Mara R Turkieltaub Paredes,Mohit Hulsurkar,Xander H T Wehrens
Mara R Turkieltaub Paredes
Inherited cardiac arrhythmias are genetic disorders that impact the heart's electrical circuitry. These disorders are caused by inherited mutations and markedly increase the mortality risk of affected individuals. Conventional treatments, s...
A Potential Ratio for Detecting Subclinical Atherosclerosis: Insight into Advanced NMR Lipid Profiles in Severe Obesity [0.03%]
检测亚临床动脉粥样硬化的潜力比率：严重肥胖患者的先进核磁共振脂质谱分析见解
Júlia Carmona-Maurici,Iratxe Eskubi-Turró,Anna Viñas et al.
Júlia Carmona-Maurici et al.
Individuals with severe obesity (SO) are at a high risk of developing cardiovascular disease, but traditional lipid parameters are insufficient for accurately assessing the risk. This study aims to investigate the advanced characteristics o...
Des-Aspartate Angiotensin-1: A Dual-Targeted Therapeutic for Perivascular Inflammation and Vascular Dysfunction in Obesity [0.03%]
去天冬氨酸血管紧张素-1：一种用于治疗肥胖相关周围血管炎症和血管功能障碍的双重作用药物
Ashok Kumar Mandal,Sharifah Zamiah Syed Abdul Kadir,Azizah Ugusman et al.
Ashok Kumar Mandal et al.
Perivascular adipose tissue (PVAT) influences the tone of vascular function through its endocrine, paracrine, and vasocrine functions. Obesity-induced PVAT inflammation promotes vascular dysfunction by shifting its secretory profile to a pr...
Regulated Cell Death and Inflammatory Signaling in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Strategies [0.03%]
糖尿病心肌病中调控性细胞死亡与炎症信号通路：机制及治疗策略
Yuyuan Lu,Jia Cui,Xueyan Cheng et al.
Yuyuan Lu et al.
Diabetic cardiomyopathy (DCM) is a common complication of diabetes, characterized by myocardial injury, fibrosis, and heart dysfunction. The pathogenesis remains poorly understood, with limited treatment options. Recent research highlights ...
Serum Interleukin-8 Levels Identify Non-Atrial Fibrillation Patients at Risk for Catheterization-Confirmed Diastolic Dysfunction: A Retrospective Cohort Study [0.03%]
血清IL-8水平可识别非房颤患者心导管证实的舒张功能不全风险：回顾性队列研究
Zhiyuan Ma,Zhiqiang Yang,Xiaotong Ji et al.
Zhiyuan Ma et al.
Left ventricular diastolic dysfunction (LVDD), confirmed by left heart catheterization, is the gold standard for diagnosing heart failure with preserved ejection fraction (HFpEF). However, current noninvasive diagnostic tools may fail to de...
The Prognostic Role of Cortisol and Glucose Dynamics in Cardiogenic Shock-Insights from a Prospective Observational Cohort [0.03%]
皮质醇和血糖动态在心脏骤停中的预后作用—来自一项前瞻性队列研究的启示
Priyanka Boettger,Laura Pallmann,Jamschid Sedighi et al.
Priyanka Boettger et al.
Cardiogenic shock (CS) following myocardial infarction remains highly fatal. The prognostic value of dynamic metabolic markers-particularly glucose and cortisol-remains incompletely understood. In this prospective cohort study, 41 patients ...
Exploratory Study of the Effects of Irreversible Electroporation on Atherosclerotic Plaque in a Rabbit Model [0.03%]
不可逆电穿孔对兔动脉粥样硬化斑块影响的初步研究
Xuying Ye,Jiashen Hu,Shisheng Cao et al.
Xuying Ye et al.
This study evaluated the effects of irreversible electroporation (IRE), a non-thermal ablation method, on carotid atherosclerotic plaques induced by high-fat feeding combined with balloon dilation in 30 rabbits. Carotid plaques were subject...