High-Throughput Preosteoblastic Spheroids Elevate Fibroblast Growth Factor 23 via Parathyroid Hormone Signaling Pathway [0.03%]
高通量研究发现成骨前体细胞球状体可通过甲状旁腺激素信号途径提高纤维细胞生长因子23水平
Jie Jiang,Jingxian Zhu,Haojie Lin et al.
Jie Jiang et al.
Fibroblast growth factor 23 (FGF23) plays a crucial role in managing renal phosphate and the synthesis of 1,25(OH)2-vitamin D3, which is essential for bone homeostasis. Developing robust in vitro systems to study FGF23-regulating mechanisms...
3D Culture Analysis of Cancer Cell Adherence to Ex Vivo Lung Microexplants [0.03%]
三维分析癌细胞对活体外肺组织移植片的粘附性
Nickolas G Diodati,Zadia E Dupee,Felipe T Lima et al.
Nickolas G Diodati et al.
Ex vivo 3D culture of human tissue explants addresses many limitations of traditional monolayer cell culture techniques, namely the lack of cellular heterogeneity and absence of 3D intercellular spatial relationships, but presents challenge...
Preventing Sheep Carotid Artery Spasm for Vascular Graft Surgery and Computed Tomography Angiography [0.03%]
预防羊颈动脉痉挛以进行血管移植手术和CT血管造影检查
Ziyu Wang,Hugh Paterson,Lisa Partel et al.
Ziyu Wang et al.
The development of small-diameter vascular grafts requires testing in large animal models before advancing to clinical trials. Vascular graft interposition implantation in sheep carotid arteries (CAs) is the most widely used model, but ovin...
Strategies for the Codelivery of Osteoclasts and Mesenchymal Stem Cells in 3D-Printable Osteochondral Scaffolds [0.03%]
基于三维打印的软骨骨移植物复合体及细胞共递送策略
Erfan Jabari,Robert H Choe,Blake Kuzemchak et al.
Erfan Jabari et al.
Osteochondral defects, characterized by structural compromises to articular cartilage and subchondral bone, can cause pain and lead to progressive cartilage damage and eventual osteoarthritis. Unfortunately, repairing these defects remains ...
Single-Step 3D Bioprinting of Alginate-Collagen Type I Hydrogel Fiber Rings to Promote Angiogenic Network Formation [0.03%]
单步法制备藻酸盐-I型胶原水凝胶纤维环用于促进血管生成网络形成
Ying Betty Li,Marina Rukhlova,Dongling Zhang et al.
Ying Betty Li et al.
In the advent of tissue engineering and regenerative medicine, the demand for innovative approaches to biofabricate complex vascular structures is increasing. We describe a single-step 3D bioprinting method leveraging Aspect Biosystems RX1 ...
Auricular Chondrocytes as a Cell Source for Scaffold-Free Elastic Cartilage Tissue Engineering [0.03%]
耳软骨细胞的支架-free弹性软骨组织工程中的细胞来源
Nicole Gonzales,Carissa Garrity,Iris Rivas et al.
Nicole Gonzales et al.
Current tissue engineering (TE) methods utilize chondrocytes primarily from costal or articular sources. Despite the robust mechanical properties of neocartilages sourced from these cells, the lack of elasticity and invasiveness of cell col...
Misleading Pore Size Measurements in Gelatin and Alginate Hydrogels Revealed by Confocal Microscopy [0.03%]
confocal microscopy揭示明胶和琼脂糖水凝胶中误导性的孔径表征结果
Alexis Franco,Bo Van Durme,Sandra Van Vlierberghe et al.
Alexis Franco et al.
It is a well-documented phenomenon that the porous structure of hydrogels observed with vacuum-based imaging techniques is generated during the freezing and drying process employed prior to observation. Nevertheless, vacuum-based techniques...
Impact of Cyclic Strain on Elastin Synthesis in a 3D Human Myometrial Culture Model [0.03%]
周期性应变对三维人子宫平滑肌模型中弹性蛋白合成的影响
Carolyn A Nietupski,Andreja Moset Zupan,Stacey C Schutte
Carolyn A Nietupski
The synthesis and assembly of mature, organized elastic fibers remains a limitation to the clinical use of many engineered tissue replacements. There is a critical need for a more in-depth understanding of elastogenesis regulation for the a...
A Biocompatible Nanofibers Modified by Plasma for Osteoblast Growth Differentiation [0.03%]
等离子体改性生物相容性纳米纤维促进成骨细胞生长分化
Quan Liu,Zhongyao Hu,Wendan Cheng et al.
Quan Liu et al.
This work employs nitrogen plasma immersion ion implantation (PIII) to modify electrospinning polylactic acid membranes and immobilizes basic fibroblast growth factors (bFGF) by forming crosslinking bonds. The study investigates the modifie...
Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-κB [0.03%]
年轻TSPC源外泌体circPVT1通过SIRT1/NF-κB改善衰老引起的细胞功能障碍
Weifeng Han,Dongqiang Gu,Xiaoya Li et al.
Weifeng Han et al.
Tendon stem/progenitor cell (TSPC) senescence is often associated with age-dependent tendon diseases and greatly reduces the capacities for tendon repair and replacement. Exosomes contain bioactive molecules and have been increasingly used ...