Dual-Stiffness Hydrogel-Based Glioblastoma In Vitro Model to Observe Cell Behavior at Interfaces [0.03%]
基于双刚度水凝胶的胶质母细胞瘤体外模型以观察界面处的细胞行为
Allison Faber,Shabnam Nejat,James Baker et al.
Allison Faber et al.
There is renewed interest in three-dimensional in vitro bioengineered models that replicate key aspects of the in vivo environment for the study of cellular behavior, with one key aspect being cell interactions with matrix interfaces. Here,...
Stephanie K Seidlits,Jeroen Jjp van den Beucken
Stephanie K Seidlits
The Size of Glioblastoma Spheroids Influences Patterns of Invasion and Temozolomide Efficacy [0.03%]
胶质母细胞瘤球形体的大小影响侵袭模式及替莫唑胺的效果
Sheridan Fok,Anagha Shreesha,Angela Appiah-Kubi et al.
Sheridan Fok et al.
Glioblastoma (GBM) is one of the most common malignant brain tumors, with patient mortality driven by invasion into the surrounding brain microenvironment and drug resistance. Multicellular spheroids are an increasingly common model to stud...
Automated Seamless Poly(ε-Caprolactone) Electrospun Tubes for Critically-Sized Bone Defect Repair [0.03%]
用于修复大型骨缺损的自动化无缝聚己内酯静电纺丝管
Kelly L O&#x;Neill,Kylie E Williams,Auveen Hajarizadeh et al.
Kelly L O&#x;Neill et al.
In this study, we demonstrate an automated approach to efficiently and reproducibly manufacture perforated poly(ε-caprolactone) (PCL) solution electrospun tubular meshes designed for critically-sized bone defect repair. The workflow improv...
An Ex Vivo Mini-Tumor Culture Protocol for Evaluating Individualized Efficacy of Chemotherapy and Immunotherapy [0.03%]
体外培养小肿瘤用于评估化疗和免疫疗法有效性的个体化差异的实验方案
Yuanfeng Fu,Yuxia Zou,Zhilong Chen et al.
Yuanfeng Fu et al.
Conventional drug screening models face a series of challenges in guiding individualized cancer treatment, including time-consuming processes, limited drug coverage, and insufficient accuracy in efficacy evaluation. This study aims to estab...
Low-Cost, Rapid Fabrication of Customizable Polyethylene Glycol-Based Cell Culture Devices [0.03%]
低成本且快速的制造聚乙二醇细胞培养器件的方法
Emily L Pallack,Maxwell W Oulundsen,Yan Kolpakov et al.
Emily L Pallack et al.
Biological research groups may face a high barrier to entry when constructing custom 3D cell culture devices to investigate multi-tissue interactions in vitro. Standard fabrication methods such as lithography, etching, or molding are expens...
Ceri-Anne E Suurmond,Natasja W M van Dijk,René van Rheden et al.
Ceri-Anne E Suurmond et al.
Patients with breast or prostate cancer have a high chance of developing bone metastasis, which is associated with many skeletal-related events. The development of novel bone metastasis treatments is lagging behind due to the lack of reliab...
Three-Dimensional Perfusion Imaging of Microcirculatory Networks Within Axially Vascularized Artificial Tissue [0.03%]
轴向血管化的人工组织内微循环网络的三维灌注成像
Christoph Koepple,Lukas Pollmann,Nicola Sariye Pollmann et al.
Christoph Koepple et al.
Evaluating the complex, three-dimensional (3D) architecture of de novo angiogenesis in artificially engineered tissue remains a significant challenge, as conventional methods like 2D histology and microimaging techniques are limited. For ax...
Evaluation of Safety and Efficacy of a Novel Alginate-Based Esophageal Mucosal Wound Protective Gel [0.03%]
评估一种新型海藻酸盐基质的食管黏膜伤口保护凝胶的安全性和疗效
Han Wang,Jiaqi Li,Minyi Yang et al.
Han Wang et al.
Background & objective: Endoscopic Submucosal Dissection (ESD) effectively treats early gastric cancer, but postoperative complications limit its clinical use. Therefore, this study examines how esophageal mucosal wound p...
In Vitro MSC Characterization of Cryopreserved Adipose Stromal Cells Processed via Uvence Workflow [0.03%]
紫外线细胞处理的冷冻保存的脂肪间充质干细胞的体外特性分析
Ahsan A Khan,Olivier D Amar,Sumila Rathnayaka M et al.
Ahsan A Khan et al.
Adipose tissue is an abundant and clinically accessible source of stromal cells. Stromal vascular fraction (SVF) and nanofat have been widely investigated for their regenerative potential; however, commercial systems vary considerably in yi...