Selina Banerjee,Ryan Brady,Lina Abu-Absi et al.
Selina Banerjee et al.
Several recent advances in microphysiological systems or organ-on-chip technology have demonstrated its potential for replacing traditional in vitro and animal models in the coming years. Despite the physiological relevance and cost-effecti...
Generation and Characterization of Induced Pluripotent Stem Cell Line UAEUi001-A from an Emirati Patient with Ventricular Septal Defect [0.03%]
来自患有室间隔缺损的阿拉伯患者的诱导多能干细胞系UAEUi001-A的建立和鉴定
Muhammad Abid Sheikh,Ekhlass Mohammed,Tanya Golani et al.
Muhammad Abid Sheikh et al.
The absence of induced pluripotent stem cell (iPSC) lines derived from Emirati patients with developmental disease hampers region-specific disease modeling and therapeutic research. Herein, we describe the creation of an iPSC line from peri...
Automated Abnormal Vessel Detection in Re-Endothelialized Mouse Lungs: A Proof of Concept [0.03%]
自动检测再内皮化小鼠肺部异常血管的概念验证
Joshua Paciocco,Ahmed Hasan,Jason Chan et al.
Joshua Paciocco et al.
Semantic segmentation was performed on 177 large histological images of re-endothelialized mouse lung vasculatures. Specifically, patch-based semantic segmentation algorithms were used to classify pixels corresponding to two classes: organ ...
Tissue-Engineered Brain-Mimetic Niches to Model Braintropic Triple-Negative Breast Cancer Metastasis [0.03%]
模拟脑转移的类脑组织工程微环境模型构建及其应用研究
Sam Freeman,John Slater
Sam Freeman
Brain metastases of triple-negative breast cancer (TNBC) rapidly progress, causing severe neurological decline with a median survival of less than 6 months. This tragic disease is often difficult to identify with sufficient time for treatme...
A Defined 3D Hydrogel Model Recapitulates Key Transcriptomic Features of Lung Adenocarcinoma [0.03%]
一种定义明确的3D水凝胶模型再现肺腺癌的关键转录组特征
Suzanne Lightsey,Heather R Kates,Kalyanee Shirlekar et al.
Suzanne Lightsey et al.
Three-dimensional (3D) culture systems have emerged as powerful tools to model tumor biology and bridge the gap between conventional two-dimensional (2D) assays and in vivo studies. Here, we evaluate a poly(ethylene glycol)-based hydrogel a...
0.1% Peracetic Acid Treatment Is the Optimal Process for Ovarian Decellularized Extracellular Matrix [0.03%]
0.1%过醋酸处理获得卵巢脱细胞基质最佳
MeyLign Long,Anita Touch,You Yang et al.
MeyLign Long et al.
This research aimed to find the optimal sterilization process for ovarian decellularized extracellular matrix (OV-dECM). OV-dECM was prepared. Four different sterilization processes, such as ultraviolet ray, 1 mg/L CuCl2 + 0.5% H2O2, 70% et...
Clonal Lineage Tracing Reveals Distinct Invasive Subpopulations in Triple-Negative Breast Cancer [0.03%]
克隆系谱追踪揭示了三阴性乳腺癌中不同的侵袭亚群
Carolina De Santiago,Andrea L Gardner,Patrik Parker et al.
Carolina De Santiago et al.
Metastatic dissemination in triple-negative breast cancer (TNBC) arises from extensive intratumoral heterogeneity, yet the clonal and transcriptional programs that underlie invasive behavior remain poorly defined. The field lacks experiment...
Dual-Stiffness Hydrogel-Based Glioblastoma In Vitro Model to Observe Cell Behavior at Interfaces [0.03%]
基于双刚度水凝胶的胶质母细胞瘤体外模型以观察界面处的细胞行为
Allison Faber,Shabnam Nejat,James Baker et al.
Allison Faber et al.
There is renewed interest in three-dimensional in vitro bioengineered models that replicate key aspects of the in vivo environment for the study of cellular behavior, with one key aspect being cell interactions with matrix interfaces. Here,...
Stephanie K Seidlits,Jeroen Jjp van den Beucken
Stephanie K Seidlits
The Size of Glioblastoma Spheroids Influences Patterns of Invasion and Temozolomide Efficacy [0.03%]
胶质母细胞瘤球形体的大小影响侵袭模式及替莫唑胺的效果
Sheridan Fok,Anagha Shreesha,Angela Appiah-Kubi et al.
Sheridan Fok et al.
Glioblastoma (GBM) is one of the most common malignant brain tumors, with patient mortality driven by invasion into the surrounding brain microenvironment and drug resistance. Multicellular spheroids are an increasingly common model to stud...