Investigation of neovascularization in three-dimensional porous scaffolds in vivo by a combination of multiscale photoacoustic microscopy and optical coherence tomography [0.03%]
结合多尺度光声显微镜和光学相干层析血管成像技术在体检测三维多孔支架中新生血管化现象的研究
Xin Cai,Yu Zhang,Li Li et al.
Xin Cai et al.
It is a grand challenge to visualize and assess in vivo neovascularization in a three-dimensional (3D) scaffold noninvasively, together with high spatial resolution and deep penetration depth. Here we used multiscale photoacoustic microscop...
Effect of oxygen concentration on viability and metabolism in a fluidized-bed bioartificial liver using ³¹P and ¹³C NMR spectroscopy [0.03%]
氧浓度对流化床生物人工肝中细胞活力及代谢的影响——结合~31P和~13C核磁共振波谱分析
Rex E Jeffries,Michael P Gamcsik,Kayvan R Keshari et al.
Rex E Jeffries et al.
Many oxygen mass-transfer modeling studies have been performed for various bioartificial liver (BAL) encapsulation types; yet, to our knowledge, there is no experimental study that directly and noninvasively measures viability and metabolis...
Storage temperatures for cold-chain delivery in cell therapy: a study of alginate-encapsulated liver cell spheroids stored at -80°c or -170°c for up to 1 year [0.03%]
用于细胞疗法的冷链递送储存温度：长达一年的藻酸盐包封肝细胞球体在-80℃或-170℃下保存的研究
Isobel Massie,Clare Selden,Humphrey Hodgson et al.
Isobel Massie et al.
Introduction: A bioartificial liver comprising alginate-encapsulated liver cell spheroids (ELS) could bridge the gap to transplant or spontaneous recovery in acute liver failure, but will be required for emergency use, ne...
Microcarrier suspension cultures for high-density expansion and differentiation of human pluripotent stem cells to neural progenitor cells [0.03%]
用于人类多能干细胞向神经祖细胞扩增和分化的微载体悬浮培养
Jo&#x;an Bardy,Allen K Chen,Yu Ming Lim et al.
Jo&#x;an Bardy et al.
Neural progenitor cells (NPCs) derived from human induced pluripotent stem cells (hiPSCs) can be differentiated to neural cells that model neurodegenerative diseases and be used in the screening of potential drugs to ameliorate the disease ...
A biocompatible tissue scaffold produced by supercritical fluid processing for cartilage tissue engineering [0.03%]
一种由超临界流体处理制备的用于软骨组织工程的生物相容性支架
Su Hee Kim,Youngmee Jung,Soo Hyun Kim
Su Hee Kim
Supercritical fluids are used in various industrial fields, such as the food and medical industries, because they have beneficial physical and chemical properties and are also nonflammable and inexpensive. In particular, supercritical carbo...
Recapitulating aspects of the oxygen and substrate environment of the damaged joint milieu for stem cell-based cartilage tissue engineering [0.03%]
基于干细胞的软骨组织工程受损关节微环境中的氧和底物方面的回顾性分析
Sven O&#x;hEireamhoin,Conor T Buckley,Elena Jones et al.
Sven O&#x;hEireamhoin et al.
Human infrapatellar fat pad contains a source of mesenchymal stem cells (FPSCs) that potentially offer a novel population for the treatment of damaged or diseased articular cartilage. Existing cartilage repair strategies such as microfractu...
Xeno-free production of human embryonic stem cells in stirred microcarrier systems using a novel animal/human-component-free medium [0.03%]
无异种成分的人胚胎干细胞微载体搅拌悬浮培养系统的建立及其新型动物/人组分完全化学定义培养基的开发
Paulo André Nobrega Marinho,Daniel Tait Vareschini,Ismael Carlos Gomes et al.
Paulo André Nobrega Marinho et al.
Currently, stem cell research faces a major bottleneck related to the low efficiency of methods to produce large quantities of human embryonic stem cells (ESC) for use in clinical trials. Most culture media currently employed for human ESC ...
Radial-flow bioreactor enables uniform proliferation of human mesenchymal stem cells throughout a three-dimensional scaffold [0.03%]
径向流生物反应器可使人类间充质干细胞在整个三维支架中均匀增殖
Aiko Katayama,Taichi Arano,Toru Sato et al.
Aiko Katayama et al.
Mesenchymal stem cells (MSCs) obtained from human bone marrow are pluripotent and have been expanded and differentiated into several kinds of mesodermal tissue in vitro. To create bioartificial tissues and organs for implantation, it is nec...
Upcyte® microvascular endothelial cells repopulate decellularized scaffold [0.03%]
UPCYTE微血管内皮细胞在脱细胞支架上的再植生长
Katharina Scheller,Iris Dally,Nadja Hartmann et al.
Katharina Scheller et al.
A general problem in tissue engineering is the poor and insufficient blood supply to guarantee tissue cell survival as well as physiological tissue function. To address this limitation, we have developed an in vitro vascularization model in...
Benefits of spine stabilization with biodegradable scaffolds in spinal cord injured rats [0.03%]
可降解支架固定对脊髓损伤修复的积极作用研究
Nuno A Silva,Rui A Sousa,Joana S Fraga et al.
Nuno A Silva et al.
Spine stabilization upon spinal cord injury (SCI) is a standard procedure in clinical practice, but rarely employed in experimental models. Moreover, the application of biodegradable biomaterials for this would come as an advantage as it wo...