Physioxia Promotes the Articular Chondrocyte-Like Phenotype in Human Chondroprogenitor-Derived Self-Organized Tissue [0.03%]
低氧促进人类软骨谱系前体衍生组织自我组装向软骨细胞表型分化
Devon E Anderson,Brandon D Markway,Kenneth J Weekes et al.
Devon E Anderson et al.
Introduction: Biomaterial-based tissue engineering has not successfully reproduced the structural architecture or functional mechanical properties of native articular cartilage. In scaffold-free tissue engineering systems...
Renal Regenerative Potential of Different Extracellular Vesicle Populations Derived from Bone Marrow Mesenchymal Stromal Cells [0.03%]
来源于骨髓间充质基质细胞的不同外泌体群体的肾再生潜能
Stefania Bruno,Marta Tapparo,Federica Collino et al.
Stefania Bruno et al.
Extracellular vesicles (EVs) derived from human bone marrow mesenchymal stromal cells (MSCs) promote the regeneration of kidneys in different animal models of acute kidney injury (AKI) in a manner comparable with the cells of origin. Howeve...
Interleukin-10 Deficiency Impairs Reparative Properties of Bone Marrow-Derived Endothelial Progenitor Cell Exosomes [0.03%]
缺省白介素-10影响骨髓来源内皮祖细胞外泌体的修复特性
Yujia Yue,Venkata Naga Srikanth Garikipati,Suresh Kumar Verma et al.
Yujia Yue et al.
Endothelial progenitor cell (EPC)-based therapy has immense potential to promote cardiac neovascularization and attenuate ischemic injury. Functional benefits of EPCs and other adult stem cell therapies largely involve paracrine mechanisms ...
Skin Regeneration with Self-Assembled Peptide Hydrogels Conjugated with Substance P in a Diabetic Rat Model [0.03%]
糖尿病大鼠模型中载P物质的自组装肽水凝胶诱导皮肤再生
Ji Eun Kim,Jung Hwa Lee,Soo Hyun Kim et al.
Ji Eun Kim et al.
The wound healing process requires enough blood to supply nutrients and various growth factors to the wound area. However, chronic wounds such as diabetic skin ulcers have limited regeneration due to a lack of cellular and molecular signals...
Structural Heteropolysaccharide Adhesion to the Glycocalyx of Visceral Mesothelium [0.03%]
结构杂多糖粘附在腹膜间皮的糖萼上
Andrew B Servais,Arne Kienzle,Cristian D Valenzuela et al.
Andrew B Servais et al.
Bioadhesives are biopolymers with potential applications in wound healing, drug delivery, and tissue engineering. Pectin, a plant-based heteropolysaccharide, has recently demonstrated potential as a mucoadhesive in the gut. Since mucoadhesi...
A Strategy to Enhance Secretion of Extracellular Matrix Components by Stem Cells: Relevance to Tissue Engineering [0.03%]
一种增强干细胞分泌细胞外基质组分的策略——组织工程的相关性研究
Navaneethakrishnan Krishnamoorthy,Yuan-Tsan Tseng,Poornima Gajendrarao et al.
Navaneethakrishnan Krishnamoorthy et al.
The ability of cells to secrete extracellular matrix proteins is an important property in the repair, replacement, and regeneration of living tissue. Cells that populate tissue-engineered constructs need to be able to emulate these function...
Exogenous miR-29B Delivery Through a Hyaluronan-Based Injectable System Yields Functional Maintenance of the Infarcted Myocardium [0.03%]
基质传递的外源性miR-29B在心肌梗死组织中的功能性表达及其对心脏功能的修复作用
Michael G Monaghan,Monika Holeiter,Eva Brauchle et al.
Michael G Monaghan et al.
Myocardial infarction (MI) results in debilitating remodeling of the myocardial extracellular matrix (ECM). In this proof-of-principle study it was sought to modulate this aggressive remodeling by injecting a hyaluronic acid-based reservoir...
Comparison of Poly(l-lactide-co-ɛ-caprolactone) and Poly(trimethylene carbonate) Membranes for Urethral Regeneration: An In Vitro and In Vivo Study [0.03%]
聚-l-乳酸-ε-己内酯和聚三甲基碳酸酯膜的尿道再生性能的对比：体外及体内研究
Reetta Sartoneva,Panu H Nordback,Suvi Haimi et al.
Reetta Sartoneva et al.
Urethral defects are normally reconstructed using a patient's own genital tissue; however, in severe cases, additional grafts are needed. We studied the suitability of poly(l-lactide-co-ɛ-caprolactone) (PLCL) and poly(trimethylene carbonat...
NELL-1, HMGB1, and CCN2 Enhance Migration and Vasculogenesis, But Not Osteogenic Differentiation Compared to BMP2 [0.03%]
与BMP2相比，NELL-1、HMGB1和CCN2可促进迁移及血管发生但不促进成骨分化
Shorouk Fahmy-Garcia,Marjolein van Driel,Janneke Witte-Buoma et al.
Shorouk Fahmy-Garcia et al.
Currently, autografts still represent the gold standard treatment for the repair of large bone defects. However, these are associated with donor-site morbidity and increased pain, cost, and recovery time. The ideal therapy would use biomate...
Biomimetic Mineralization of Biomaterials Using Simulated Body Fluids for Bone Tissue Engineering and Regenerative Medicine<sup/> [0.03%]
基于模拟体液的骨组织工程和再生医学用生物材料仿生矿化研究
Kyungsup Shin,Timothy Acri,Sean Geary et al.
Kyungsup Shin et al.
Development of synthetic biomaterials imbued with inorganic and organic characteristics of natural bone that are capable of promoting effective bone tissue regeneration is an ongoing goal of regenerative medicine. Calcium phosphate (CaP) ha...