In Vivo Differentiation of hESC-Derived Neural Crest Cells into Trabecular Meshwork Cells [0.03%]
人胚胎干细胞源性神经嵴细胞体外分化成为小梁网细胞
Ying Su,Haoyun Duan,Hai Zhu et al.
Ying Su et al.
Primary open-angle glaucoma is a prevalent type of degenerative eye disease that results in lifelong blindness, and its critical pathogenic cause is trabecular meshwork (TM) dysfunction or decreased TM cellularity. Considering that TM devel...
Optimizing Bioactive Glass-Nanoparticle-Polymer Blend Scaffolds: A Shift in Bone Regeneration Design [0.03%]
用于骨组织工程的生物活性玻璃-聚合物基质复合材料的设计及优化
Duangruedee Khwannimit,Ayuth Vejpongsa,Thanaphum Wannalobon et al.
Duangruedee Khwannimit et al.
Scaffolds for bone tissue engineering have traditionally been designed to mimic the inorganic-to-organic ratio of mature bone, aiming to recapitulate its mechanical properties. However, early bone repair is not characterized by immediate me...
β3GALT2 Gene Promotes Osteogenic Differentiation of BMSCs on n-HA/PA66 Via Exosomes [0.03%]
β3GALT2基因通过外泌体促进n-HA/PA66上BMSCs成骨分化
Lipeng Peng,Jian Yang,Linnan Wang et al.
Lipeng Peng et al.
While β3GalT2 has been implicated in osteogenic regulation, its synergistic application with bioactive scaffolds remains unexplored. This study pioneers a dual-functional bone regeneration strategy by integrating β3GalT2-engineered bone m...
The Impact of Vascular Supply on Endochondral Bone Regeneration in Centimeter-Sized Porous Chambers [0.03%]
血管供应对厘米级多孔腔室中软骨内骨骼再生的影响
Leanne S de Silva,Casper J Kuijpers,Ellen M Van Cann et al.
Leanne S de Silva et al.
The current clinical treatment of large bone defects in humans primarily relies on autologous bone grafts. However, the use of autologous bone grafts can be limited by tissue availability, variable bone quality, and donor site morbidity. In...
Regenerative Potential of Human Umbilical Cord Vein for Urethral Reconstruction in Male Rabbit Model [0.03%]
人脐静脉用于雄兔尿道重建的再生潜能研究
Clement Parat,Damien Carnicelli,Stephan Langonnet et al.
Clement Parat et al.
Tissue engineering offers an alternative for augmentation urethroplasty; however, no ideal material has yet been developed. Recently, materials derived from amniotic tissues appear to exhibit promising properties. Herein, the aim of this st...
A Novel Injectable Cell-Loaded Hydrogel System for Cartilage Repair: In Vivo and In Vitro Study [0.03%]
一种新型的载细胞可注射水凝胶修复软骨并进行体内和体外研究
Beini Mao,Ming Tian,Yuling Yin et al.
Beini Mao et al.
Polyhydroxyalkanoates are promising biomaterials, but their application in cartilage repair is still limited. In this study, an injectable thermosensitive hydrogel poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate)-Polyethyl...
Effect of Microbial Stimuli and Bone Morphogenetic Protein 2 on Ectopic Bone Formation [0.03%]
微生物刺激和骨形态发生蛋白2对异位成骨的影响
Nada Ristya Rahmani,Anneli Duits,Paree Khokhani et al.
Nada Ristya Rahmani et al.
Advancements in biomaterials design increasingly focus on material-host immune interactions as one of the strategies to promote new bone formation, referred to as osteoimmunomodulation. Recent studies indicate that inflammatory stimuli can ...
In Situ Bioprinting Embryonic-Derived Stem Cells to Repair Human Ex Vivo Chondral Defects [0.03%]
原位生物打印胚胎干细胞修复体外人软骨缺损
Shawn P Grogan,Erik W Dorthé,Nicholas E Glembotski et al.
Shawn P Grogan et al.
Successful bioprinting requires an appropriate combination of bioinks, cells, and a delivery platform. To demonstrate the potential of in situ bioprinting for regeneration of cartilage lesions we combined clinically relevant embryonic-deriv...
Glycations on Decellularized Muscle Matrix Reduce Muscle Regeneration and Increase Inflammation [0.03%]
脱细胞肌肉基质上的糖基化反应会减弱肌肉再生并增加炎症反应
Lucas C Olson,Ammar Y Jawad,Eirian S Crocker et al.
Lucas C Olson et al.
Volumetric muscle loss (VML) due to traumatic injury results in the abrupt loss of contractile units, stem cells, and connective tissue, leading to long-term muscle dysfunction and reduced regenerative potential. Muscle connective tissue co...
Modular, Vascularized Hypertrophic Cartilage Constructs for Bone Tissue Engineering Applications [0.03%]
用于骨组织工程应用的模块化、血管化肥大软骨构建体
Nicholas G Schott,Gurcharan Kaur,Rhima M Coleman et al.
Nicholas G Schott et al.
Insufficient vascularization is the main barrier to creating engineered bone grafts for treating large and ischemic defects. Modular tissue engineering approaches have promise in this application because of the ability to combine tissue typ...