Scaffold Fiber Architecture and Uniaxial Stretch Differentially Regulate Cell and Nuclear Morphology in Human Dermal Fibroblasts [0.03%]
人真皮成纤维细胞的支架纤维架构和单轴拉伸对细胞及核形态的差异化调节作用
Maria I Echeverria Molina,Kyriakos Komvopoulos
Maria I Echeverria Molina
Cellular and nuclear morphology, together with directional alignment, are fundamental determinants of cell function and play critical roles in the formation, organization, and maintenance of functional fibrous connective tissues. In tissue-...
Macrophages Primed with Hyaluronic Acid Promote Bone Regeneration in Mouse Peri-Implantitis Model [0.03%]
透明质酸预激活的巨噬细胞促进小鼠种植体周围炎模型骨再生
Yumi Miwa,Naoki Tsuji,Kazuto Hoshi et al.
Yumi Miwa et al.
Peri-implantitis is characterized by bacterial infection and progressive destruction of surrounding tissues, with limited long-term therapeutic strategies. Although macrophages could have therapeutic effects on peri-implantitis, macrophage-...
Exploring Spatial Patterning of Endothelial Cells and Trophoblast Cells in a Microfluidic Device [0.03%]
微流控装置内血管内皮细胞和滋养层细胞的空间分布规律探究
Sia Mittal,Hannah S Theriault,Katie Karecki et al.
Sia Mittal et al.
Trophoblast invasion into the decidualized endometrium is an important aspect of blastocyst implantation necessary for a successful pregnancy. There are many processes involving the early implantation and invasion of trophoblast cells into ...
Teriflunomide Slows Osteoarthritis Progression via Wnt/β-Catenin and NLRP3 Pyroptosis Pathways [0.03%]
特氟立moz抑制Wnt/β-catenin和NLRP3吡咯菌素途径从而减缓骨关节炎的进展
Yiqiang Zhang,Xiaojuan Zeng,Xiang Xu et al.
Yiqiang Zhang et al.
Osteoarthritis (OA) is a progressive, degenerative joint disorder characterized by irreversible loss of articular cartilage, in which NLRP3 inflammasome-mediated chondrocyte pyroptosis and dysregulated Wnt/β-catenin signaling are recognize...
An Integrated Organoid-on-a-Chip Platform for Modeling the Human Placental Barrier [0.03%]
一种集成的类器官芯片平台，用于模拟人类胎盘屏障模型
Zitang Qi,Dianrong Song,Zhiqiang Liu
Zitang Qi
The placental barrier plays a critical role in protecting the fetus from xenobiotics and regulating the maternal-fetal exchange. However, conventional trophoblast cell lines and animal models often fail to accurately recapitulate the key st...
Natural Polysaccharide Scaffolds as Immunomodulatory Biomaterials for Tissue Regeneration [0.03%]
天然多糖支架作为组织再生的免疫调节生物材料
Nilgun Yakubogullari,Ahu Arslan-Yildiz
Nilgun Yakubogullari
Tissue repair and regeneration represent multifaceted processes involving a coordinated interplay of diverse cell types, growth factors, and cytokines. Following tissue injury, innate immune cells serve as the primary cellular responders th...
Mesenchymal Stem/Stromal Cells-Derived Exosomal Micro-RNA Delivery Enhances Bone Repair in Osteoporotic Conditions [0.03%]
间充质干细胞来源的外泌体微小RNA递送促进骨质疏松条件下的骨修复
Subhasis Mandal,Lauren Kim,Minjee Kang et al.
Subhasis Mandal et al.
Osteoporosis-associated bone fractures are a leading cause of disability in the elderly population. Developing effective therapeutic strategies to enhance bone repair under osteoporotic conditions remains a major clinical challenge. Increas...
A Universal Model to Align Heterochrony of Chondrogenesis Across Species [0.03%]
一种跨物种软骨发生异时性对齐的通用模型
Xinyi Liu,Jiaxuan Zheng,Boon Chin Heng et al.
Xinyi Liu et al.
Although embryonic chondrogenesis follows conserved developmental stages across mammalian species, the rate of this process varies significantly. We hypothesized that these varying developmental rates could be normalized and modeled by alig...
Impact of Hematocrit on Normothermic Machine Perfusion of Rat Liver Grafts and Viability Testing [0.03%]
贮存后大鼠肝移植机器灌注携氧能力对肝脏存活率的影响研究
Johannes R Bornemann,Linda Gilles,Vincent Appel et al.
Johannes R Bornemann et al.
Normothermic machine perfusion (NMP) has emerged as a new technique for organ storage before liver transplantation, making viability testing of the organ feasible and possibly allowing for reconditioning of marginal liver grafts. Erythrocyt...