Designing for Growth: Structural Insights into 3D-Printed Composite Scaffolds for Bone Repair [0.03%]
用于骨修复的3D打印复合支架的成长设计：结构见解
Areonna C Schreiber,Xifeng Liu,Asghar Rezaei et al.
Areonna C Schreiber et al.
Critical-sized bone defects remain a significant clinical challenge, as their size prevents spontaneous healing and necessitates surgical intervention. Although autografts are considered the clinical gold standard, their use is limited by d...
COVID-19 and Tissue Engineering: What Have We Accomplished in the Past 5 Years? [0.03%]
新冠疫情下的组织工程：过去五年我们取得了哪些成果？
Walid K Bibi,Avha R Mohanty,Alexander M Tatara
Walid K Bibi
The Coronavirus Disease of 2019 (COVID-19) pandemic caused by SARS-CoV-2 resulted in widespread mortality, economic strain, and healthcare system disruption, highlighting the need for effective strategies to address viral threats. Tissue en...
Injectable Silk Fibroin/Tannic Acid Hydrogel with Dual Factors for Meniscus Repair [0.03%]
具有双因子的可注射丝素/单宁酸水凝胶半月板修复研究
Mingxue Chen,Hao Wang,Zhijie Zhao et al.
Mingxue Chen et al.
Despite advances in tissue engineering, the clinical application of scaffolds for meniscal repair remains limited by implantation challenges and the difficulty of directing stem cells toward a stable meniscal phenotype. Here, we present an ...
Identifying Mechano-Modulators of Myometrial Contractility in a Scalable Hydrogel Culture Platform [0.03%]
基于可扩展的水凝胶培养平台鉴定子宫平滑肌收缩力的调控因子
Isabella C Claure,Catherine M Klapperich,Joyce Y Wong
Isabella C Claure
Maternal and fetal health during pregnancy is closely tied to contractile modulation of the uterine myometrium, as dysfunctional contractions underlie pregnancy complications such as preterm labor and postpartum hemorrhaging. Structural abn...
Jujuboside A-Loaded Exosomes Alleviate Pulmonary Fibrosis via TGF-β/Smad and Autophagy Regulation [0.03%]
载山竹叶醇A外泌体通过调节TGF-β/Smads和自噬缓解肺纤维化
Jing Liu,Shuli Zhang,Yi Sun et al.
Jing Liu et al.
This study aimed to scrutinize the antifibrotic effects of jujuboside A-loaded exosomes (JuA-Exo) on TGF-β1-induced MRC-5 fibroblasts and explore the pathophysiological basis. Exosomes were isolated from human mesenchymal stem cells and lo...
Anthony N Aggouras,Matthew T Lim,Mikayla Bradsby et al.
Anthony N Aggouras et al.
While it is generally accepted that tendon healing following widespread extracellular matrix trauma is limited, tenocytes are thought to have the capacity to repair small amounts of microdamage generated through activities of daily living t...
Functional Imaging for Regenerative Medicine: Tracking Vascularization of Intestinal Scaffolds [0.03%]
用于再生医学的功能性影像技术：追踪肠道支架的血管化现象
Jared A Weis,Mani Ratnam Kothamasu,Nildris Cruz-Diaz et al.
Jared A Weis et al.
Traditional approaches to tissue-engineered small intestine (TESI) require implanting a construct in the omentum of the abdominal cavity to allow for vascularization of the construct and tissue maturation. A second operation is then needed ...
Timing Matters: Impact of Flow and Hypoxia on Capillary Tube Formation in Bioartificial Fibrin-Based Matrices [0.03%]
时机至关重要：流动和低氧对生物人工基质中微管形成的影响
Florian Helms,Hanna Kühne,Michael Pflaum et al.
Florian Helms et al.
Vascularization and perfusion are essential for tissue engineering of large-scale bioartificial tissues and organs. Both fluid flow and hypoxia have been shown to influence capillary tube formation in bioartificial matrices. However, the id...
The Effect of Pore Size on Cell Ingrowth in PLLA/HA Scaffolds for Bone Tissue Engineering [0.03%]
多孔PLLA/HA复合支架的孔径大小对细胞长入的影响研究
Xinna Bai,Shuping Peng,Zhangui Tang et al.
Xinna Bai et al.
In bone regenerative medicine, scaffolds play a pivotal role in promoting cell adhesion, proliferation, and differentiation. Among the various materials employed for creating scaffolds, mixed materials composed of poly-l-lactic acid and hyd...
Kai Zhang,Andres J Garcia,Yuliang Zhao
Kai Zhang