Matrix-Bound Nanovesicles Recapitulate Extracellular Matrix Effects on Macrophage Phenotype [0.03%]
基质结合型纳米囊泡模拟细胞外基质对巨噬细胞表型的影响
Luai Huleihel,Joseph G Bartolacci,Jenna L Dziki et al.
Luai Huleihel et al.
The early macrophage response to biomaterials has been shown to be a critical and predictive determinant of downstream outcomes. When properly prepared, bioscaffolds composed of mammalian extracellular matrix (ECM) have been shown to promot...
Inhibition of Pathological Phenotype of Hypertrophic Scar Fibroblasts Via Coculture with Adipose-Derived Stem Cells [0.03%]
脂肪来源干细胞与增生性瘢痕成纤维细胞共培养抑制增生性瘢痕的病理表型
Jingcheng Deng,Yuan Shi,Zhen Gao et al.
Jingcheng Deng et al.
Hypertrophic scar (HS) is a dermal fibroproliferative disease characterized by fibroblast over-proliferation, overproduction, and deposition of the extracellular matrix. Growing evidence demonstrated that adipose-derived stem cells (ASCs) s...
Justin Drager,Jose Luis Ramirez-GarciaLuna,Abhishek Kumar et al.
Justin Drager et al.
Tissue hypoxia is a critical driving force for angiogenic and osteogenic responses in bone regeneration and is, at least partly, under the control of the Hypoxia Inducible Factor-1α (HIF-1α) pathway. Recently, the widely used iron chelato...
Alaa Mansour,Mohamed Amine Mezour,Zahi Badran et al.
Alaa Mansour et al.
The gold standard material for bone regeneration is still autologous bone, a mesenchymal tissue that consists mainly of extracellular matrix (ECM) (90% v/v) and little cellular content (10% v/v). However, the fact that decellularized alloge...
Tina P Dale,Shazia Mazher,William R Webb et al.
Tina P Dale et al.
Tendon healing is complex to manage because of the limited regeneration capacity of tendon tissue; stem cell-based tissue engineering approaches may provide alternative healing strategies. We sought to determine whether human embryonic stem...
Thyroxine Increases Collagen Type II Expression and Accumulation in Scaffold-Free Tissue-Engineered Articular Cartilage [0.03%]
甲状腺素增加无支架组织工程关节软骨中II型胶原的表达和积累
G Adam Whitney,Thomas J Kean,Russell J Fernandes et al.
G Adam Whitney et al.
Low collagen accumulation in the extracellular matrix is a pressing problem in cartilage tissue engineering, leading to a low collagen-to-glycosaminoglycan (GAG) ratio and poor mechanical properties in neocartilage. Soluble factors have bee...
* Composite Biomaterial as a Carrier for Bone-Active Substances for Metaphyseal Tibial Bone Defect Reconstruction in Rats [0.03%]
复合生物材料作为载骨活性物质修复大鼠胫骨干质骨缺损的支架
Peter Frederik Horstmann,Deepak Bushan Raina,Hanna Isaksson et al.
Peter Frederik Horstmann et al.
Restoring lost bone is a major challenge in orthopedic surgery. Currently available treatment strategies have shortcomings, such as risk of infection, nonunion, and excessive resorption. Our primary aim was to study if a commercially availa...
Suitability of Different Natural and Synthetic Biomaterials for Dental Pulp Tissue Engineering [0.03%]
不同天然和合成生物材料在牙髓组织工程中的适用性研究
Kerstin M Galler,Ferdinand P Brandl,Susanne Kirchhof et al.
Kerstin M Galler et al.
Dental pulp tissue engineering is possible after insertion of pulpal stem cells combined with a scaffold into empty root canals. Commonly used biomaterials are collagen or poly(lactic) acid, which are either difficult to modify or to insert...
* Programmed Platelet-Derived Growth Factor-BB and Bone Morphogenetic Protein-2 Delivery from a Hybrid Calcium Phosphate/Alginate Scaffold [0.03%]
*预编程序列化血小板源性生长因子BB和骨形成蛋白2从杂化磷酸钙/藻酸盐支架中释放
Emily A Bayer,Jahnelle Jordan,Abhijit Roy et al.
Emily A Bayer et al.
Bone tissue engineering requires the upregulation of several regenerative stages, including a critical early phase of angiogenesis. Previous studies have suggested that a sequential delivery of platelet-derived growth factor (PDGF) to bone ...
Biocompatibility of Intensified Decellularized Equine Carotid Arteries in a Rat Subcutaneous Implantation Model and in a Human In Vitro Model [0.03%]
脱细胞马颈动脉的生物相容性研究：以大鼠皮下植入模型和人源体外模型评价
Niklas Jeinsen,Lavinia Mägel,Danny Jonigk et al.
Niklas Jeinsen et al.
Limited biocompatibility of decellularized scaffolds is an ongoing challenge in tissue engineering. We recently demonstrated that intensified detergent-based decellularization of equine carotid artery (dEACintens) removed residual cellular ...