* Biomineralized Recombinant Collagen-Based Scaffold Mimicking Native Bone Enhances Mesenchymal Stem Cell Interaction and Differentiation [0.03%]
仿生矿化重组胶原支架模拟天然骨组织并促进间充质干细胞相互作用及分化
Gloria Belén Ramírez-Rodríguez,Monica Montesi,Silvia Panseri et al.
Gloria Belén Ramírez-Rodríguez et al.
The need of synthetic bone grafts that recreate from macro- to nanoscale level the biochemical and biophysical cues of bone extracellular matrix has been a major driving force for the development of new generation of biomaterials. In this s...
* Engineering Osteoinductive Biomaterials by Bioinspired Synthesis of Apatite Coatings on Collagen Hydrogels with Varied Pore Microarchitectures [0.03%]
通过生物启发合成在具有不同孔隙微结构的胶原蛋白水凝胶上制备磷酸钙涂层，从而工程化成骨诱导生物材料
Jacqueline L Harding,Matthew J Osmond,Melissa D Krebs
Jacqueline L Harding
Biomaterial controlled osteoinduction is influenced by the porous microenvironment and the composition of incorporated calcium orthophosphate (CaPi) polymorphs, however, for the design of materials that rival the efficacies of natural graft...
Human Plasma Rich in Growth Factors Improves Survival and Neurite Outgrowth of Spiral Ganglion Neurons In Vitro [0.03%]
富含生长因子的人血浆可改善螺旋神经节神经元的体外存活率和轴突生长
Michael Stolle,Jennifer Schulze,Ariane Roemer et al.
Michael Stolle et al.
Background: Platelet-rich and platelet-poor plasma (PRP and PPP) are autologous preparations from peripheral blood and contain several growth factors and cytokines involved in tissue repair. Although their neuroprotective...
Induced Redifferentiation of Human Chondrocytes from Articular Cartilage Lesion in Alginate Bead Culture After Monolayer Dedifferentiation: An Alternative Cell Source for Cell-Based Therapies? [0.03%]
藻酸盐珠培养中人关节软骨损伤部位成软骨细胞单层去分化后的诱导红分化：基于细胞治疗的替代细胞来源？
Matthias Aurich,Gunther O Hofmann,Norman Best et al.
Matthias Aurich et al.
Human chondrocytes isolated from articular cartilage (AC) lesions as an alternative cell source to the standard nonweight-bearing notch biopsy site may hold clinical potential for cell-based therapies. The aim was to characterize human AC l...
Mechanically Loading Cell/Hydrogel Constructs with Low-Intensity Pulsed Ultrasound for Bone Repair [0.03%]
低强度脉冲超声波加载细胞/水凝胶基质构建体促进骨再生修复
James A Veronick,Fayekah Assanah,Nicole Piscopo et al.
James A Veronick et al.
Low-intensity pulsed ultrasound (LIPUS) has been shown to be effective for orthopedic fracture repair and nonunion defects, but the specific mechanism behind its efficacy is still unknown. Previously, we have shown a measurable acoustic rad...
Composite Scaffolds of Mineralized Natural Extracellular Matrix on True Bone Ceramic Induce Bone Regeneration Through Smad1/5/8 and ERK1/2 Pathways [0.03%]
仿生矿化天然细胞外基质复合真骨陶瓷通过Smad1/5/8和ERK1/2信号通路诱导骨再生
Tingfang Sun,Sheng Yao,Man Liu et al.
Tingfang Sun et al.
A stem cell-derived mineralized extracellular matrix (ECM) may be a good strategy to endow scaffolds with a bone microenvironment, thus inducing bone regeneration. However, it also faces some challenges, such as limited number of cells, add...
Transcriptome-Wide Analyses of Human Neonatal Articular Cartilage and Human Mesenchymal Stem Cell-Derived Cartilage Provide a New Molecular Target for Evaluating Engineered Cartilage [0.03%]
人类新生儿关节软骨和人 mesenchymal干细胞生成的软骨的转录组分析为评估工程化软骨提供了新的分子靶点
Rodrigo A Somoza,Diego Correa,Ivan Labat et al.
Rodrigo A Somoza et al.
Cellular differentiation comprises a progressive, multistep program that drives cells to fabricate a tissue with specific and site distinctive structural and functional properties. Cartilage constitutes one of the potential differentiation ...
Hypoxic Three-Dimensional Cellular Network Construction Replicates Ex Vivo the Phenotype of Primary Human Osteocytes [0.03%]
缺氧三维细胞网络构建体外重现人原代骨细胞表型
Saba Choudhary,Qiaoling Sun,Ciaran Mannion et al.
Saba Choudhary et al.
Osteocytes are deeply embedded in the mineralized matrix of bone and are nonproliferative, making them a challenge to isolate and maintain using traditional in vitro culture methods without sacrificing their inimitable phenotype. We studied...
In Vitro Maturation of Human iPSC-Derived Neuroepithelial Cells Influences Transplant Survival in the Stroke-Injured Rat Brain [0.03%]
体外成熟的人类iPSC来源的神经上皮细胞移植后在脑卒大鼠模型中的存活率不同
Samantha L Payne,Priya N Anandakumaran,Balazs V Varga et al.
Samantha L Payne et al.
Stem cell transplantation is a promising strategy for brain tissue regeneration; yet, despite some success, cell survival following transplantation remains low. In this study, we demonstrate that cell viability is enhanced by control over m...
A Systematic Evaluation of Factors Affecting Extracellular Vesicle Uptake by Breast Cancer Cells [0.03%]
影响乳腺癌细胞摄取外泌体因素的系统评价
Devin M Stranford,Michelle E Hung,Emma S Gargus et al.
Devin M Stranford et al.
Extracellular vesicles (EVs) are nanometer-scale particles that are secreted by cells and mediate intercellular communication by transferring biomolecules between cells. Harnessing this mechanism for therapeutic biomolecule delivery represe...