Synergistic Therapeutic Effect of Three-Dimensional Stem Cell Clusters and Angiopoietin-1 on Promoting Vascular Regeneration in Ischemic Region [0.03%]
三维干细胞团与Angiopoietin-1在缺血区域促进血管再生的协同治疗效应
Jung-Mi Kang,Jeong-Kee Yoon,Seong-Ja Oh et al.
Jung-Mi Kang et al.
Peripheral artery disease (PAD) is an ischemic disease characterized by reduced blood flow to the legs, feet, and hands. Human mesenchymal stem cells are an attractive cell source to treat PAD in regenerative medicine. However, in clinical ...
Marc Burghartz,Simon Lennartz,Matthias Schweinlin et al.
Marc Burghartz et al.
The loss of salivary gland function caused by radiation therapy of the head and neck is a serious condition and it affects a patient's quality of life. The current lack of effective therapies demands new options to be explored. This study t...
In Vitro Bioactivity of One- and Two-Dimensional Nanoparticle-Incorporated Bone Tissue Engineering Scaffolds [0.03%]
一维和二维纳米粒子增强骨组织工程支架的体外活性研究
Jason T Rashkow,Gaurav Lalwani,Balaji Sitharaman
Jason T Rashkow
This study investigates the effect of incorporation of one- or two-dimensional nanoparticles with distinct composition and morphology on the bioactivity of biodegradable, biocompatible polymer matrices. 0.2 wt% multiwalled carbon nanotubes,...
* Mimicking the Biochemical and Mechanical Extracellular Environment of the Endochondral Ossification Process to Enhance the In Vitro Mineralization Potential of Human Mesenchymal Stem Cells [0.03%]
模拟软骨内骨骼发育的生化和力学微环境以提高人源间充质干细胞体外矿化潜能
Fiona E Freeman,Jessica Schiavi,Meadhbh A Brennan et al.
Fiona E Freeman et al.
Chondrogenesis and mechanical stimulation of the cartilage template are essential for bone formation through the endochondral ossification process in vivo. Recent studies have demonstrated that in vitro regeneration strategies that mimic th...
Focal Adhesion Kinase Activation Is Necessary for Stretch-Induced Alignment and Enhanced Differentiation of Myogenic Precursor Cells [0.03%]
肌生成祖细胞伸展诱导对齐及分化增强需要 focal adhesion kinase 的激活
Jens Isak Andersen,Cristian Pablo Pennisi,Trine Fink et al.
Jens Isak Andersen et al.
Myogenic precursors sense and dynamically respond to mechanical stimulation through complex integrin-mediated mechanotransduction, in which focal adhesion kinase (FAK) is a fundamental intracellular signaling mediator. When skeletal myoblas...
Directly Induced Neural Differentiation of Human Adipose-Derived Stem Cells Using Three-Dimensional Culture System of Conductive Microwell with Electrical Stimulation [0.03%]
基于导电微孔阵列的三维培养系统直接诱导人脂肪来源干细胞向神经元分化
Dong Nyoung Heo,Nana Acquah,Junghoon Kim et al.
Dong Nyoung Heo et al.
Adipose-derived stem cells (ADSCs) have the capacity to differentiate into neural precursor cells which can be used for nerve regeneration. However, their inherently low neurogenic differentiation efficiency limits further clinical applicat...
Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells [0.03%]
用条件性重编程的人支气管上皮细胞重构小鼠肺组织
Ryan LaRanger,Jennifer R Peters-Hall,Melissa Coquelin et al.
Ryan LaRanger et al.
We developed methods for conditionally reprogramming (CR) primary human bronchial epithelial cells (HBECs) to extend their functional lifespan and permit their differentiation into both upper and lower airway lung epithelium. We also develo...
Repair of Tympanic Membrane Perforations with Customized Bioprinted Ear Grafts Using Chinchilla Models [0.03%]
用定制的生物打印耳移植物修复耳鼠模型的鼓膜穿孔修复的研究
Che-Ying Kuo,Emmanuel Wilson,Andrew Fuson et al.
Che-Ying Kuo et al.
The goal of this work is to develop an innovative method that combines bioprinting and endoscopic imaging to repair tympanic membrane perforations (TMPs). TMPs are a serious health issue because they can lead to both conductive hearing loss...
The Immunomodulatory Role of BMP-2 on Macrophages to Accelerate Osteogenesis [0.03%]
BMP-2调控巨噬细胞促进骨再生的机制研究进展
Fei Wei,Yinghong Zhou,Jing Wang et al.
Fei Wei et al.
Bone morphogenetic protein-2 (BMP-2) is one of the most frequently used osteogenic factors for osteogenesis. Macrophages, acting as both immune cells and osteoclast precursors, have an indispensable functional input during multiple stages o...
Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model [0.03%]
Fuchs内皮角膜 dystrophy细胞和组织模型中的基底膜成分及整合素表达谱型分析
Benjamin Goyer,Mathieu Thériault,Sébastien P Gendron et al.
Benjamin Goyer et al.
Primary corneal endothelial cell (CEC) cultures and 3D-engineered tissue models were used to study the aberrant deposition of extracellular matrix (ECM) in a vision impairing pathology known as Fuchs endothelial corneal dystrophy (FECD). CE...