Osteoclast Incorporation in an In Vitro 3D Model of Endochondral Ossification [0.03%]
一种终末软骨内骨化的体外三维模型中的破骨细胞侵入作用
Amaia Garmendia Urdalleta,Janneke Witte-Bouma,Nicole Kops et al.
Amaia Garmendia Urdalleta et al.
In vitro models aim to recapitulate human physiological processes, improving upon and replacing the need for animal-based models. Modeling bone formation via endochondral ossification in vitro is a very complex process due to the large numb...
Surface-Patterned Silicon Oxynitride for Aligned Myotubes and Neurite Outgrowth In Vitro [0.03%]
体外排列的肌管和神经突生长的表面图案化硅氧化氮薄膜
Kamal Awad,Matthew Fiedler,Ahmed S Yacoub et al.
Kamal Awad et al.
Traumatic injuries lead to volumetric muscle loss (VML) and nerve damage that cause chronic functional deficits. Due to the inability of mammalian skeletal muscle to regenerate after VML damage, engineered scaffolds have been explored to ad...
Three-Dimensional Bioprinting of Astrocytes and Endothelial Cells to Direct Retinal Axon Growth and Vascularization [0.03%]
通过三维生物打印技术使用星形胶质细胞和内皮细胞促进视网膜轴突生长和血管化
Fatima E Abukunna,Afnan M Aladdad,Kiran J McLoughlin et al.
Fatima E Abukunna et al.
Retinal organoids (ROs) are currently used to study retinal development and diseases but cannot model glaucoma because they fail to form a nerve fiber layer (NFL) and optic nerve (ON). Utilizing three-dimensional bioprinting, ON head astroc...
Microencapsulation of Liver Spheroids with Poly(Vinyl Alcohol) Enhances Function Compared with Alginate [0.03%]
微凝胶壳材料对肝类器官三维培养功能影响的研究——聚乙烯醇优于海藻酸钠
Stephen Harrington,Edward Larson,Aldyn Wildey et al.
Stephen Harrington et al.
Background and Aims: Cell therapy approaches to treating chronic liver disease provide only transient improvements, mainly due to loss of hepatocytes after infusion. Microencapsulation in alginate has been shown to protect transplanted cell...
Osteoblast-Mesenchymal Stem Cell Coculture Drives In Vitro Osteogenesis in 3D Bioprinted Periosteum [0.03%]
体外三维生物打印骨膜中骨形成的成骨细胞-间充质干细胞共培养机制研究
Shannon T McLoughlin,Paige Wilcox,John F Caccamese et al.
Shannon T McLoughlin et al.
The periosteum serves as a local source of osteoprogenitor cells and vasculature, therefore influencing the key processes of osteogenesis and neovascularization during bone healing. However, it is often not considered in traditional bone ti...
Aging Impairs Implant Osseointegration Through a Novel Reactive Oxygen Species-Hypoxia-Inducible Factor 1α/p53 Axis [0.03%]
衰老通过新的活性氧-缺氧诱导因子1α/p53轴影响植入物骨整合
Jingjing Shao,Shibo Liu,Chenfeng Chen et al.
Jingjing Shao et al.
Enhancing bone-vessel coupling to form high-quality vascular-rich peri-implant bone is crucial for improving implant prognosis in elder patients. Notably, hypoxia-inducible factor 1α (HIF1α) is known to promote osteogenesis-angiogenesis c...
ZC3H13 Regulates Ferroptosis to Enhance Osteogenic Differentiation in Osteoporotic BMSCs [0.03%]
ZC3H13通过调控铁死亡以增强骨质疏松BMSCs的成骨分化能力
Qiang Zhu,Zhezheng Chen,Ting Fu et al.
Qiang Zhu et al.
Objectives: N6-methyladenosine (m6A) modification is critical in the regulation of osteoporosis (OP). Although ZC3H13 is an important m6A methyltransferase, its specific regulatory effects and mechanisms in osteoporosis are not yet fully un...
Characterization of Native Extracellular Matrix of Patient-Derived Glioblastoma Multiforme Organoids [0.03%]
源自患者的多形性母细胞瘤类器官的天然细胞外基质的特性分析
Alexandra D Avera,Daniel J Gibson,Macy L Birge et al.
Alexandra D Avera et al.
Model systems play a crucial role in biological and biomedical research, especially in the search for new treatments for challenging diseases such as glioblastoma multiforme (GBM). Organoids are 3D in vitro multicellular "middle-ground" mod...
Profiles of Exosomal microRNAs in Joint Cells and Candidate microRNAs for Cartilage Regeneration [0.03%]
关节细胞中外泌体microRNAs的分布以及候选的软骨修复microRNAs
Venkateswaran Ganesh,Rui He,Henry L Keen et al.
Venkateswaran Ganesh et al.
The activation of chondrogenic progenitor cells (CPCs) in articular cartilage during a traumatic injury is vital for cartilage regeneration. Although our understanding of the mechanisms underlying CPC chondrogenic activation remains incompl...
Matrix-Bound Nanovesicles Promote Prohealing Immunomodulation Without Immunosuppression [0.03%]
矩阵结合的纳米囊泡可促进促愈合免疫调节而不会导致免疫抑制
Héctor Capella-Monsonís,Raphael J Crum,William D&#x;Angelo et al.
Héctor Capella-Monsonís et al.
Bioscaffolds composed of extracellular matrix (ECM) have been shown to promote a profound transition in macrophages and T-cells from a proinflammatory to a prohealing phenotype with associated site-appropriate and constructive tissue remode...