Biomimetic Composite Scaffold Containing Small Intestinal Submucosa and Mesoporous Bioactive Glass Exhibits High Osteogenic and Angiogenic Capacity [0.03%]
含小肠亚黏膜和介孔生物活性玻璃的仿生复合支架表现出较高的成骨和促血管生成潜能
Tingfang Sun,Man Liu,Sheng Yao et al.
Tingfang Sun et al.
Biomaterials with excellent osteogenic and angiogenic activities are desirable to repair massive bone defects. Decellularized matrix from porcine small intestinal submucosa (SIS) has attracted particular attention for tissue regeneration be...
Fibronectin Enhances Cartilage Repair by Activating Progenitor Cells Through Integrin α5β1 Receptor [0.03%]
纤连蛋白通过整合素α5β1受体活化软骨祖细胞促进软骨修复
Tianqi Tao,Yang Li,Chang Gui et al.
Tianqi Tao et al.
This study aimed to determine the effect of fibronectin (FN) on cartilage regeneration through the activation of chondrogenic progenitor cells (CPCs). Cells were isolated from the knee cartilage of mice and cultured in the presence of vario...
Autologous Smooth Muscle Progenitor Cells Enhance Regeneration of Tissue-Engineered Bladder [0.03%]
自身平滑肌干细胞增强组织工程膀胱的再生修复功能
Liuhua Zhou,Jiadong Xia,Pengji Wang et al.
Liuhua Zhou et al.
Tissue engineering techniques provide a great potential to de novo construct a histological bladder. Smooth muscle regeneration is extremely important for the functional recovery of engineered neobladder. However, many challenges remain for...
A Cell-Engineered Small Intestinal Submucosa-Based Bone Mimetic Construct for Bone Regeneration [0.03%]
一种基于细胞工程化的小肠亚粘膜的骨仿生构建体用于骨再生
Mei Li,Chi Zhang,Yuxing Mao et al.
Mei Li et al.
Extracellular matrix (ECM)-ornamented biomaterials have attracted attention due to their high potential to improve the biofunctionality of original materials. It is thought that ECM with a bone mimetic microenvironment generated by the spec...
Liposomal Delivery of Demineralized Dentin Matrix for Dental Tissue Regeneration [0.03%]
脱矿牙本质基质的脂质体递送促进牙组织再生
Genevieve E Melling,John S Colombo,Steven J Avery et al.
Genevieve E Melling et al.
Current dental restorations have short longevity, and consequently, there is a need for novel tissue engineering strategies that aim to regenerate the dentin-pulp complex. Dentin matrix contains a myriad of bioactive growth factors and extr...
Evaluation of Detergent-Free and Detergent-Based Methods for Decellularization of Murine Skin [0.03%]
无表面活性剂和含表面活性剂的脱细胞小鼠皮肤的方法评价
Ali Farrokhi,Mohammadreza Pakyari,Layla Nabai et al.
Ali Farrokhi et al.
Acute and chronic wounds contribute to increased morbidity and mortality in affected people and impose significant financial burdens on healthcare systems. For these challenging wounds, acellular dermal matrices (ADMs) have been used as a b...
Kartogenin Enhanced Chondrogenesis in Cocultures of Chondrocytes and Bone Mesenchymal Stem Cells [0.03%]
kartogenin增强软骨细胞和骨髓基质细胞共培养体系中的软骨生成效应
Chun Liu,Tao Li,Zhijian Yang et al.
Chun Liu et al.
Articular cartilage has poor capability of regeneration due to the avascular surrounding and low metabolic activity. Kartogenin (KGN), an emerging nonprotein heterocyclic compound, was screened to stimulate chondrogenic differentiation of b...
Biological and Mechanical Factors Promote the Osteogenesis of Rabbit Artificial Vertebral Laminae: A Comparison Study [0.03%]
生物学和机械因素促进兔人工椎板成骨的研究：一项对比研究
Linli Li,Xujun Chen,Yiqun He et al.
Linli Li et al.
Reconstruction of vertebral laminae without epidural scar formation has been challenging. The success of bone formation depends on the biological and mechanical conditions of the surrounding tissues. In this study, we aimed to investigate t...
Comparative Study
Tissue engineering. Part A. 2018 Jul;24(13-14):1082-1090. DOI:10.1089/ten.TEA.2017.0426 2018
Human Wharton's Jelly Cells Activate Degenerative Nucleus Pulposus Cells In Vitro [0.03%]
人羊膜间充质干细胞通过体外实验活化退变的椎间盘细胞
Zhihua Han,Yan Zhang,Liang Gao et al.
Zhihua Han et al.
To investigate the interaction between human Wharton's jelly cells (WJCs) and degenerative nucleus pulposus cells (NPCs), human WJCs were cocultured with degenerative NPCs with or without direct cell-cell contact. WJCs were isolated from th...
Recombinant Extracellular Matrix Protein Fragments Support Human Embryonic Stem Cell Chondrogenesis [0.03%]
重组细胞外基质蛋白片段支持人胚胎干细胞软骨分化
Aixin Cheng,Stuart A Cain,Pinyuan Tian et al.
Aixin Cheng et al.
We previously developed a 14-day culture protocol under potentially GMP, chemically defined conditions, to generate chondroprogenitors from human embryonic stem cells (hESCs). In vivo work has confirmed the cartilage repair capacity of thes...