Oversized Biodegradable Arterial Grafts Promote Enhanced Neointimal Tissue Formation [0.03%]
巨大的可降解动脉移植物能促进增生内膜组织的形成
Cameron Best,Takuma Fukunishi,Joseph Drews et al.
Cameron Best et al.
Most tissue-engineered arterial grafts are complicated by aneurysmal dilation secondary to insufficient neotissue formation after scaffold degradation. The optimal graft would form an organized multilayered structure with a robust extracell...
Silk Biomaterials-Mediated miRNA Functionalized Orthopedic Devices [0.03%]
基于丝素生物材料的microRNA功能化骨科医疗器械
Eric N James,Emily Van Doren,Chunmei Li et al.
Eric N James et al.
Silk-based bioresorbable medical devices, such as screws, plates, and rods, have been under investigation due to their promising properties for orthopedic repairs. Options to functionalize these new devices for enhanced control of bone rege...
ROCK Inhibition Promotes the Development of Chondrogenic Tissue by Improved Mass Transport [0.03%]
ROCK抑制通过改善物质输送促进软骨组织的发育
Kuo-Chen Wang,Thomas T Egelhoff,Arnold I Caplan et al.
Kuo-Chen Wang et al.
Human mesenchymal stem cell (hMSC)-based chondrogenesis is a key process used to develop tissue engineered cartilage constructs from stem cells, but the resulting constructs have inferior biochemical and biomechanical properties compared to...
Comparison of Different In Vivo Incubation Sites to Produce Tissue-Engineered Small Intestine [0.03%]
不同体内孵育部位构建组织工程小肠的比较研究
Yanchun Liu,Barrett P Cromeens,Yijie Wang et al.
Yanchun Liu et al.
Objective: The objective of this study was to compare the impact of different in vivo incubation sites on the production of tissue-engineered small intestine (TESI). ...
Comparative Study
Tissue engineering. Part A. 2018 Jul;24(13-14):1138-1147. DOI:10.1089/ten.TEA.2017.0313 2018
Sheila A Grant,Jiaxun Zhu,Jonathan Gootee et al.
Sheila A Grant et al.
Collagen soft tissue fillers suffer from fast reabsorption, which minimizes their use as a tissue-engineered construct. Extensive cross-linking can be utilized to extend longevity, but changes in microstructure and biomechanics can have del...
Runheng Liu,Wei Qiao,Baoxin Huang et al.
Runheng Liu et al.
In a previous study, we successfully prepared fluorinated porcine hydroxyapatite (FPHA) by immersing porcine hydroxyapatite (PHA) in an aqueous solution of 0.25 M sodium fluoride (NaF) under thermal treatment, and the resulting FPHA showed ...
Improved Osteogenesis by HVEM-Expressing Allogenic Bone Marrow-Derived Mesenchymal Stem Cells in an Immune Activation Condition and Mouse Femoral Defect Model [0.03%]
免疫激活条件下HVEM基因修饰的同种异体骨髓间充质干细胞促进大鼠股骨缺损模型成骨效应增强
Zhigang Rong,Fei Zhang,Zhengdong Wang et al.
Zhigang Rong et al.
Use of allogeneic mesenchymal stem cells (allo-MSCs) in bone tissue engineering strategies can overcome the limitations associated with autologous MSCs, but unfortunately, the immunogenicity of allo-MSCs leads to a high rate of rejection, u...
Perfusion Enhances Hypertrophic Chondrocyte Matrix Deposition, But Not the Bone Formation [0.03%]
灌注促进软骨细胞基质沉积，但不影响骨骼形成
Jonathan C Bernhard,Elizabeth Hulphers,Bernhard Rieder et al.
Jonathan C Bernhard et al.
Perfusion bioreactors have been an effective tool in bone tissue engineering. Improved nutrient delivery and the application of shear forces have stimulated osteoblast differentiation and matrix production, allowing for generation of large,...
Mineralized Biomaterials Mediated Repair of Bone Defects Through Endogenous Cells [0.03%]
基于内源细胞的矿化生物材料介导骨缺损修复
Eva C González Díaz,Yu-Ru V Shih,Manando Nakasaki et al.
Eva C González Díaz et al.
Synthetic biomaterials that create a dynamic calcium (Ca2+)-, phosphate (PO43-) ion-, and calcium phosphate (CaP)-rich microenvironment, similar to that found in native bone tissue, have been shown to promote osteogenic commitment of stem c...
Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells [0.03%]
基于人类干细胞的大脑皮层类器官模拟神经退行性疾病微环境
Yuanwei Yan,Liqing Song,Julie Bejoy et al.
Yuanwei Yan et al.
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders and causes cognitive impairment and memory deficits of the patients. The mechanism of AD is not well known, due to lack of human brain models. Recently, mini-bra...