Initial In Vitro Development of a Potassium-Based Intra-Articular Injection for Osteoarthritis [0.03%]
一种治疗骨关节炎的钾基关节腔注射剂的体外初期开发研究
Josh Erndt-Marino,Patricia Diaz-Rodriguez,Mariah S Hahn
Josh Erndt-Marino
The long-term goal of this work is to develop a potassium (K+)-based intra-articular (IA) injection for osteoarthritis treatment. Within this context, the objectives of this study were to (1) demonstrate that hyperosmolar K+ solutions can s...
In Vivo Periodontium Formation Around Titanium Implants Using Periodontal Ligament Cell Sheet [0.03%]
采用牙周膜细胞片在体内形成钛种植体的牙周组织
Kaoru Washio,Yusuke Tsutsumi,Yuka Tsumanuma et al.
Kaoru Washio et al.
Osseointegrated implants have been recognized as being very reliable and having long-term predictability. However, host defense mechanisms against infection have been known to be impaired around a dental implant because of the lack of a per...
Harnessing an Inhibitory Role of miR-16 in Osteogenesis by Human Mesenchymal Stem Cells for Advanced Scaffold-Based Bone Tissue Engineering [0.03%]
利用人 mesenchymal 干细胞中 miR-16 的抑制作用进行高级支架基骨组织工程
Irene Mencía Castaño,Caroline M Curtin,Garry P Duffy et al.
Irene Mencía Castaño et al.
MicroRNA (miRNA) therapeutics is increasingly being developed to either target bone-related diseases such as osteoporosis and osteoarthritis or as the basis for novel bone tissue engineering strategies. A number of miRNAs have been reported...
Effect of Brain-Derived Neurotrophic Factor on the Neurogenesis and Osteogenesis in Bone Engineering [0.03%]
脑源性神经营养因子对骨组织工程中外胚层衍生细胞神经发生和成骨的影响
Qing Liu,Lei Lei,Tao Yu et al.
Qing Liu et al.
During bone growth, the lack of a neuralized vascular network in the regenerating area can affect subsequent bone quality. This study aimed to investigate if brain-derived neurotrophic factor (BDNF) could promote neurogenesis and osteogenes...
A Comparison of Bone Marrow and Cord Blood Mesenchymal Stem Cells for Cartilage Self-Assembly [0.03%]
自体组装软骨的骨髓间充质干细胞与脐带血间充质干细胞的比较研究
Jamie L White,Naomi J Walker,Jerry C Hu et al.
Jamie L White et al.
Joint injury is a common cause of premature retirement for the human and equine athlete alike. Implantation of engineered cartilage offers the potential to increase the success rate of surgical intervention and hasten recovery times. Mesenc...
Comparative Study
Tissue engineering. Part A. 2018 Aug;24(15-16):1262-1272. DOI:10.1089/ten.TEA.2017.0424 2018
Engineering the Second Generation of Therapeutic Cells with Enhanced Targeting of Injured Tissues [0.03%]
工程改造治疗性细胞的第二代以增强其对受损组织的目标定位能力
Mark L Wang,Pedro K Beredjiklian,Andrzej Steplewski et al.
Mark L Wang et al.
Experimental approaches to improving tissue repair utilize cells and growth factors needed to restore the architecture and function of damaged tissues and organs. Key limitations of these approaches include poor delivery of therapeutic cell...
Shear Conditioning of Adipose Stem Cells for Reduced Platelet Binding to Engineered Vascular Grafts [0.03%]
用于工程血管移植物的减少血小板结合的脂肪干细胞剪切调理
Anh La,Robert T Tranquillo
Anh La
Conferring antithrombogenicity to tissue-engineered vascular grafts remains a major challenge, especially for urgent bypass grafting that excludes approaches based on expanding autologous endothelial cells (ECs) that requires weeks of cell ...
Cross-Linked Cholecyst-Derived Extracellular Matrix for Abdominal Wall Repair [0.03%]
用于腹壁修复的胆囊衍生的交联细胞外基质
Jeffrey C Y Chan,Krishna Burugapalli,Yi-Shiang Huang et al.
Jeffrey C Y Chan et al.
Abdominal wall repair frequently utilizes either nondegradable or biodegradable meshes, which are found to stimulate undesirable biological tissue responses or which possess suboptimal degradation rate. In this study, a biologic mesh protot...
Nanoparticle-Mediated Cell Capture Enables Rapid Endothelialization of a Novel Bare Metal Stent [0.03%]
纳米颗粒介导的细胞捕获能使新型裸金属支架快速内皮化
Brandon J Tefft,Susheil Uthamaraj,Adriana Harbuzariu et al.
Brandon J Tefft et al.
Incomplete endothelialization of intracoronary stents has been associated with stent thrombosis and recurrent symptoms, whereas prolonged use of dual antiplatelet therapy increases bleeding-related adverse events. Facilitated endothelializa...
Decellularized Muscle Supports New Muscle Fibers and Improves Function Following Volumetric Injury [0.03%]
去细胞化肌肉支持体积损伤后的新生肌纤维并改善功能
Michael J McClure,David J Cohen,Allison N Ramey et al.
Michael J McClure et al.
Current strategies to treat volumetric muscle loss use primarily pedicle or free muscle transfers, but these grafts fail to adequately regenerate functional tissue. Decellularized soft tissue grafts possess physical and chemical cues to pro...