Development of PEI-RANK siRNA Complex Loaded PLGA Nanocapsules for the Treatment of Osteoporosis [0.03%]
开发用于治疗骨质疏松症的PEI-RANK siRNA复合载药PLGA纳米胶囊
Deniz Sezlev Bilecen,Hasan Uludag,Vasif Hasirci
Deniz Sezlev Bilecen
Osteoporosis, which is characterized by low bone mineral density and susceptibility to fracture, is caused by increased osteoclastic activity. Receptor activator of nuclear factor kappa B ligand (RANKL)/RANK signaling plays an important rol...
Improvement of Bone Healing by Neutralization of microRNA-335-5p, but not by Neutralization of microRNA-92A in Bone Marrow Mononuclear Cells Transplanted into a Large Femur Defect of the Rat [0.03%]
中和microRNA-335-5P而不是中和microRNA-92a可改善移植骨髓单个核细胞修复大段股骨缺损后的骨骼愈合
Maren Janko,Konstantin Dietz,Julia Rachor et al.
Maren Janko et al.
Transplanted bone marrow mononuclear cells (BMC) support the healing of large bone defects. Neutralization of microRNA (MiR) that negatively affects key processes of the reparative response in BMC might help to further improve the beneficia...
An Engineered Human Adipose/Collagen Model for In Vitro Breast Cancer Cell Migration Studies [0.03%]
一种工程人类脂肪/胶原模型用于体外乳腺癌细胞迁移研究
Robert D Hume,Lorraine Berry,Stefanie Reichelt et al.
Robert D Hume et al.
Adipocytes are one of the major stromal cell components of the human breast. These cells play a key role in the development of the gland and are implicated in breast tumorigenesis. Frequently, directional stromal collagen I fibers are found...
Anirudha Singh,David Lee,Harrison Jeong et al.
Anirudha Singh et al.
Decellularized tissues have been increasingly popular for constructing scaffolds for tissue engineering applications due to their beneficial biological compositions and mechanical properties. It is therefore natural to consider decellulariz...
Transient Scleraxis Overexpression Combined with Cyclic Strain Enhances Ligament Cell Differentiation [0.03%]
瞬时Scleraxis过表达结合周期性拉伸应变促进韧带细胞分化
Anne E C Nichols,Stephen R Werre,Linda A Dahlgren
Anne E C Nichols
Efforts to generate tissue-engineered anterior cruciate ligament replacements are limited by a lack of methods to derive mature ligament cells. Viral overexpression of the tendon/ligament marker scleraxis (Scx) can drive cell differentiatio...
Acceleration of Diabetic Wound Healing with PHD2- and miR-210-Targeting Oligonucleotides [0.03%]
靶向PHD2和miR-210寡核苷酸加速糖尿病伤口愈合
Anne Dallas,Artem Trotsyuk,Heini Ilves et al.
Anne Dallas et al.
In diabetes-associated chronic wounds, the normal response to hypoxia is impaired and many cellular processes involved in wound healing are hindered. Central to the hypoxia response is hypoxia-inducible factor-1α (HIF-1α), which activates...
Maximizing the Translational Yield of mRNA Therapeutics by Minimizing 5'-UTRs [0.03%]
通过最小化5'-UTR来最大化mRNA治疗的转化收益
Zeljka Trepotec,Manish K Aneja,Johannes Geiger et al.
Zeljka Trepotec et al.
The 5'-untranslated region (5'-UTR) of mRNA contains structural elements, which are recognized by cell-specific RNA-binding proteins, thereby affecting the translation of the molecule. The activation of an innate immune response upon transf...
Decellularized Cartilage Directs Chondrogenic Differentiation: Creation of a Fracture Callus Mimetic [0.03%]
脱细胞软骨引导软骨分化：仿制骨折愈合组织
Wollis J Vas,Mittal Shah,Thomas S Blacker et al.
Wollis J Vas et al.
Complications that arise from impaired fracture healing have considerable socioeconomic implications. Current research in the field of bone tissue engineering predominantly aims to mimic the mature bone tissue microenvironment. This approac...
Reinforced Electrospun Polycaprolactone Nanofibers for Tracheal Repair in an In Vivo Ovine Model [0.03%]
用于体内绵羊模型气管修复的增强型聚己内酯纳米纤维电纺丝技术
Jakob M Townsend,Lindsey M Ott,Jean R Salash et al.
Jakob M Townsend et al.
Tracheal stenosis caused by congenital anomalies, tumors, trauma, or intubation-related damage can cause severe breathing issues, diminishing the quality of life, and potentially becoming fatal. Current treatment methods include laryngotrac...
Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair [0.03%]
用于周围神经修复的光交联胶原/弹性蛋白多糖黏合剂
Jonathan R Soucy,Ehsan Shirzaei Sani,Roberto Portillo Lara et al.
Jonathan R Soucy et al.
Suturing peripheral nerve transections is the predominant therapeutic strategy for nerve repair. However, the use of sutures leads to scar tissue formation, hinders nerve regeneration, and prevents functional recovery. Fibrin-based adhesive...