Genetic Engineering of Mesenchymal Stem Cells for Differential Matrix Deposition on 3D Woven Scaffolds [0.03%]
基因工程介导的间充质干细胞在三维编织支架上差异性沉积细胞外基质的研究
Nguyen P T Huynh,Jonathan M Brunger,Catherine C Gloss et al.
Nguyen P T Huynh et al.
Tissue engineering approaches for the repair of osteochondral defects using biomaterial scaffolds and stem cells have remained challenging due to the inherent complexities of inducing cartilage-like matrix and bone-like matrix within the sa...
Notochordal Cell Matrix As a Therapeutic Agent for Intervertebral Disc Regeneration [0.03%]
软骨细胞基质作为治疗椎间盘再生的药物
Stefan de Vries,Marina van Doeselaar,Björn Meij et al.
Stefan de Vries et al.
Notochordal cells (NCs) reside in the core of the healthy disc and produce soluble factors that can stimulate nucleus pulposus cells (NPCs). These NC-derived factors may be applied in intervertebral disc regeneration for treatment of low-ba...
Biofabricated Structures Reconstruct Functional Urinary Bladders in Radiation-Injured Rat Bladders [0.03%]
生物制造结构修复放射损伤的实验大鼠膀胱功能
Tetsuya Imamura,Mitsuru Shimamura,Teruyuki Ogawa et al.
Tetsuya Imamura et al.
The ability to repair damaged urinary bladders through the application of bone marrow-derived cells is in the earliest stages of development. We investigated the application of bone marrow-derived cells to repair radiation-injured bladders....
A Three-Dimensional Human Tissue-Engineered Lung Model to Study Influenza A Infection [0.03%]
一种用于研究流感病毒感染的三维人体组织工程肺模型
Rudra Bhowmick,Tahereh Derakhshan,Yurong Liang et al.
Rudra Bhowmick et al.
Influenza A virus (IAV) claims ∼250,000-500,000 lives annually worldwide. Currently, there are a few in vitro models available to study IAV immunopathology. Monolayer cultures of cell lines and primary lung cells (two-dimensional [2D] cell...
Calcium-Infiltrated Biphasic Hydroxyapatite Scaffolds for Human Hematopoietic Stem Cell Culture [0.03%]
钙渗透双相羟基磷灰石支架用于人类造血干细胞培养
Qinghao Zhang,Jörg C Gerlach,Ian Nettleship et al.
Qinghao Zhang et al.
Long-term in vitro expansion of hematopoietic stem cells (HSCs), while maintaining their functionality and multilineage differentiation potential, is still challenging. In this study, three-dimensional (3D) high-porosity hydroxyapatite (HA)...
Assembly of Tissue-Engineered Blood Vessels with Spatially Controlled Heterogeneities [0.03%]
具有空间控制异质性的组织工程血管的组装
Hannah A Strobel,Tracy A Hookway,Marco Piola et al.
Hannah A Strobel et al.
Tissue-engineered human blood vessels may enable in vitro disease modeling and drug screening to accelerate advances in vascular medicine. Existing methods for tissue-engineered blood vessel (TEBV) fabrication create homogenous tubes not co...
Mesenchymal Stem Cell Sheets Exert Antistenotic Effects in a Rat Arterial Injury Model [0.03%]
间充质干细胞片在大鼠动脉损伤模型中的抗增生作用
Jun Homma,Hidekazu Sekine,Katsuhisa Matsuura et al.
Jun Homma et al.
Restenosis after catheter or surgical intervention substantially affects the prognosis of arterial occlusive disease. Mesenchymal stem cells (MSCs) may have antistenotic effects on injured arteries. MSC transplantation from the adventitial ...
Aligned Nanofibrillar Scaffolds for Controlled Delivery of Modified mRNA [0.03%]
用于输送改良型mRNA的平行纳纤维支架
Tatiana S Zaitseva,Cynthia Alcazar,Maedeh Zamani et al.
Tatiana S Zaitseva et al.
RNA-based vector delivery is a promising gene therapy approach. Recent advances in chemical modification of mRNA structure to form modified mRNA (mmRNA or cmRNA or modRNA) have substantially improved their stability and translational effici...
Antonio Santisteban-Espejo,Fernando Campos,Laura Martin-Piedra et al.
Antonio Santisteban-Espejo et al.
Tissue engineering (TE) is defined as a multidisciplinary scientific discipline with the main objective to develop artificial bioengineered living tissues to regenerate damaged or lost tissues. Since its appearance in 1988, TE has globally ...
Hyaluronic Acid Dictates Chondrocyte Morphology and Migration in Composite Gels [0.03%]
透明质酸在复合凝胶中决定软骨细胞形态和迁移
Renu Mohan,Neethu Mohan,Dhanesh Vaikkath
Renu Mohan
Tissue equivalent collagen-hyaluronic acid-based hydrogels are widely used for cartilage tissue engineering; however, not much importance has been given to investigate how cellular responses are altered with varying concentrations of hyalur...