Calcium Sulphate/Hydroxyapatite Carrier for Bone Formation in the Femoral Neck of Osteoporotic Rats [0.03%]
硫酸钙/羟基磷灰石载体在骨质疏松大鼠股骨头形成中的应用
Aurimas Širka,Deepak Bushan Raina,Hanna Isaksson et al.
Aurimas Širka et al.
This study investigated bone regeneration in the femoral neck canal of osteoporotic rats using a novel animal model. A calcium sulphate (CS)/hydroxyapatite (HA) carrier was used to deliver a bisphosphonate, zoledronic acid (ZA), locally, wi...
A Fluidic Culture Platform for Spatially Patterned Cell Growth, Differentiation, and Cocultures [0.03%]
一种用于细胞生长、分化及共培养的空间图案化流体芯片平台
Josephine Lembong,Max J Lerman,Tami J Kingsbury et al.
Josephine Lembong et al.
Stem cell cultures within perfusion bioreactors, while efficient in obtaining cell numbers, often lack the similarity to native tissues and consequently cell phenotype. We develop a three-dimensional (3D)-printed fluidic chamber for dynamic...
An Organotypic Reconstructed Human Urethra to Study Chlamydia trachomatis Infection [0.03%]
一种用于研究沙眼衣原体感染的组织工程尿道模型
Bart Versteeg,Lenie J van den Broek,Sylvia M Bruisten et al.
Bart Versteeg et al.
Organotypic models to investigate host-microbiome interactions are still a challenge for the field of tissue engineering. This is particularly the case for organs such as the urethra. Several cell line, animal, and tissue models are availab...
Donor Variation and Optimization of Human Mesenchymal Stem Cell Chondrogenesis in Hyaluronic Acid [0.03%]
透明质酸中人骨髓间充质干细胞软骨分化的供者差异及优化研究
Minwook Kim,Isaac E Erickson,Alice H Huang et al.
Minwook Kim et al.
Mesenchymal stem cells (MSCs) are an attractive cell type for cartilage repair that can undergo chondrogenesis in a variety of three-dimensional (3D) scaffolds. Hyaluronic acid (HA) hydrogels provide a biologically relevant interface for ce...
Repair of Articular Osteochondral Defects Using an Integrated and Biomimetic Trilayered Scaffold [0.03%]
一种整合仿生的三层结构支架修复关节软骨缺损的研究
Chenjun Zhai,Hao Fei,Junzheng Hu et al.
Chenjun Zhai et al.
Repair of articular cartilage defects using bilayered scaffolds is problematic because tissue-engineered cartilage is prone to overgrowth toward subchondral bone, resulting in structural abnormalities of cartilage and subchondral bone. A "t...
Osteoinduction by Ex Vivo Nonviral Bone Morphogenetic Protein Gene Delivery Is Independent of Cell Type [0.03%]
体外非病毒骨形态发生蛋白基因递送的诱导成骨作用与细胞类型无关
Loek D Loozen,Moyo C Kruyt,Angela Vandersteen et al.
Loek D Loozen et al.
Ex vivo nonviral gene delivery of bone inductive factors has the potential to heal bone defects. Due to their inherent role in new bone formation, multipotent stromal cells (MSCs) have been studied as the primary target cell for gene delive...
Anti-Inflammatory Peptide Attenuates Edema and Promotes BMP-2-Induced Bone Formation in Spine Fusion [0.03%]
抗炎肽可减轻肿胀并促进颈椎融合中BMP-2诱导的骨形成
Juliane D Glaeser,Khosrowdad Salehi,Linda E A Kanim et al.
Juliane D Glaeser et al.
Recombinant human bone morphogenic protein-2 (BMP-2)-loaded absorbable collagen sponges (ACS) have been successfully used to enhance bone formation and to induce spinal fusion in humans. However, side effects, such as soft tissue edema and ...
Overcoming Challenges in Engineering Large, Scaffold-Free Neocartilage with Functional Properties [0.03%]
工程大型无支架仿生软骨组织的挑战及展望
Brian J Huang,Wendy E Brown,Thomas Keown et al.
Brian J Huang et al.
Although numerous cartilage engineering methods have been described, few report generation of constructs greater than 4 cm2, which is the typical lesion size considered for cell-based therapies. Furthermore, current cell-based therapies onl...
Enhanced Sternal Healing Through Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel [0.03%]
富血小板血浆和可生物降解明胶水凝胶促进胸骨加速愈合
Masafumi Shibata,Gen Takagi,Mitsuhiro Kudo et al.
Masafumi Shibata et al.
Platelet-rich plasma (PRP) contains numerous growth factors and promotes bone fracture healing. The aim of this study was to evaluate the effectiveness of the controlled release of PRP from biodegradable gelatin hydrogel for promoting heali...
Skin Regeneration with a Scaffold of Predefined Shape and Bioactive Peptide Hydrogels [0.03%]
基于预定义形状和生物活性肽水凝胶的皮肤再生疗法
Heejung Im,Su Hee Kim,Soo Hyun Kim et al.
Heejung Im et al.
We developed a highly elastic customized scaffold for soft tissue regeneration and combined them with bioactive hydrogels with stem cell-inducing ability. This was done to mimic mechanical properties of native soft tissues and improve the v...