Frontal Bone Healing Is Sensitive to Wnt Signaling Inhibition via Lentiviral-Encoded Beta-Catenin Short Hairpin RNA [0.03%]
载有β-连环素短发卡RNA的慢病毒对额骨愈合的影响
Lei Zhang,Leslie Chang,Jiajia Xu et al.
Lei Zhang et al.
The Wnt/β-catenin signaling pathway plays an integral role in skeletal biology, spanning from embryonic skeletal patterning through bone maintenance and bone repair. Most experimental methods to antagonize Wnt signaling in vivo are either ...
Gelatin-Based Microribbon Hydrogels Accelerate Cartilage Formation by Mesenchymal Stem Cells in Three Dimensions [0.03%]
基于明胶的微带水凝胶通过三维培养加速间充质干细胞软骨分化
Bogdan Conrad,Li-Hsin Han,Fan Yang
Bogdan Conrad
Hydrogels (HGs) are attractive matrices for cell-based cartilage tissue regeneration given their injectability and ability to fill defects with irregular shapes. However, most HGs developed to date often lack cell scale macroporosity, which...
Sclerostin-Neutralizing Antibody Enhances Bone Regeneration Around Oral Implants [0.03%]
抗骨硬化素抗体能促进口腔种植体周骨缺损的修复
Shan Huey Yu,Jie Hao,Tobias Fretwurst et al.
Shan Huey Yu et al.
Background: Dental implants are an important option for replacement of missing teeth. A major clinical challenge is how best to accelerate bone regeneration and reduce the healing time for functional restoration after imp...
Cyclic Uniaxial Tensile Strain Enhances the Mechanical Properties of Engineered, Scaffold-Free Tendon Fibers [0.03%]
循环单轴拉伸应变增强了工程化无支架肌腱纤维的力学性能
Kuwabo Mubyana,David T Corr
Kuwabo Mubyana
The treatment of injured tendon is an ever-increasing clinical and financial burden, for which tissue-engineered replacements have shown great promise. Recently, there has been growing interest in a more regenerative approach to tissue engi...
Stromal Cell Derived Factor-1-Mediated Migration of Mesenchymal Stem Cells Enhances Collagen Type II Expression in Intervertebral Disc [0.03%]
基质细胞衍生因子-1介导的间充质干细胞迁移促进椎间盘内Ⅱ型胶原表达
Catarina Leite Pereira,Graciosa Quelhas Teixeira,Joana Rita Ferreira et al.
Catarina Leite Pereira et al.
Intervertebral disc (IVD) degeneration is characterized by an unbalanced cell catabolic/anabolic activity and cell death, resulting in the degradation of extracellular matrix components and water loss. Repopulating the IVD with new cells ma...
Effects of Tunable Keratin Hydrogel Erosion on Recombinant Human Bone Morphogenetic Protein 2 Release, Bioactivity, and Bone Induction [0.03%]
可调角蛋白水凝胶侵蚀对重组人骨形态发生蛋白2释放、生物活性和骨诱导的影响
David Joshua Cohen,Sharon L Hyzy,Salma Haque et al.
David Joshua Cohen et al.
Recombinant human bone morphogenetic protein 2 (rhBMP-2) delivery from collagen sponges for bone formation is an important clinical example of growth factors in tissue engineering. Side effects from rhBMP-2 burst release and rapid collagen ...
Hui-Yi Hsiao,Chin-Yu Yang,Jia-Wei Liu et al.
Hui-Yi Hsiao et al.
Periosteal osteogenic capacity can be exploited to enhance bone formation in the fields of tissue engineering and regenerative medicine. Despite this importance, there have been no studies examining the composition, structure, and osteogeni...
Adipose-Derived Stem Cells in a Resilient In Situ Forming Hydrogel Modulate Macrophage Phenotype [0.03%]
具有抗性的原位交联水凝胶中脂肪来源干细胞对巨噬细胞表型的调控作用
Stuart A Young,Lauren E Flynn,Brian G Amsden
Stuart A Young
Injectable hydrogels have the potential to enhance stem cell-based therapies by improving cell localization, retention, and survival after transplantation. The inflammatory response to both the hydrogel and the encapsulated cells is a criti...
CXCR4 Has the Potential to Enhance Bone Formation in Osteopenic Rats [0.03%]
CXCR4通过促进骨形成细胞的增殖和分化而潜在增强骨质疏松大鼠骨量的作用研究
Anita Sanghani,Liza Osagie-Clouard,Soureouseh Samizadeh et al.
Anita Sanghani et al.
Osteoporosis is characterized by reduced bone mass and aberrant bone microarchitecture, thus increasing susceptibility to fracture due to reduced strength and quality. The aims of this study were to investigate the role of CXCR4 transfected...
Mechanical and Biochemical Effects of Progesterone on Engineered Cervical Tissue [0.03%]
孕酮对宫颈组织体外模型的机械和生化效应研究
Michael House,Jeannie Kelly,Nikolai Klebanov et al.
Michael House et al.
Preterm birth is a leading cause of morbidity and mortality in newborns. Babies born prematurely are at increased risk of lifelong health problems, including neurodevelopmental abnormalities. Cervical shortening precedes preterm birth in ma...