Characterization of the Proliferating Layer Chondrocytes of Growth Plate for Cartilage Regeneration [0.03%]
生长板增殖层软骨细胞的特征及其在软骨再生中的应用研究
Zi-Miao Liu,Po-Chih Shen,Cheng-Chang Lu et al.
Zi-Miao Liu et al.
In recent years, cell-based therapy is a promising strategy for repairing defect cartilage. However, in vitro expansion of articular chondrocytes (ACs) for collecting enough cell numbers eventually develops cell de-differentiation. In the p...
Osteochondral Differentiation of Fluorescent Multireporter Cells on Zonally-Organized Biomaterials [0.03%]
荧光多报告细胞在分区组织生物材料上的软骨和软骨下分化
Drew S Clearfield,Xiaonan Xin,Sumit Yadav et al.
Drew S Clearfield et al.
This study represents significant advancement in the use of biomimetic scaffolds to direct zonal osteochondral tissue formation. We describe the use of a novel fluorescent reporter system that enables the real-time evaluation of cellular di...
Nanotechnology Enabled Modulation of Signaling Pathways Affects Physiologic Responses in Intact Vascular Tissue [0.03%]
纳米技术介导的信号通路调节影响完整血管组织的生理反应
Kyle M Hocking,Brian C Evans,Padmini Komalavilas et al.
Kyle M Hocking et al.
Subarachnoid hemorrhage (SAH) is associated with vasospasm that is refractory to traditional vasodilators, and inhibition of vasospasm after SAH remains a large unmet clinical need. SAH causes changes in the phosphorylation state of the sma...
Comparison of Decellularized Cow and Human Bone for Engineering Bone Grafts with Human Induced Pluripotent Stem Cells [0.03%]
用人诱导多能干细胞工程骨移植比较脱细胞牛骨和人骨的效果
Martina Sladkova,Jiayi Cheng,Michael Palmer et al.
Martina Sladkova et al.
Decellularized tissue matrices are popular as scaffolding materials for tissue engineering application. However, it is unclear whether interspecies differences in tissue parameters influence the quality of tissue grafts that are engineered ...
Comparative Study
Tissue engineering. Part A. 2019 Feb;25(3-4):288-301. DOI:10.1089/ten.TEA.2018.0149 2019
Controlled Release of Small Molecules for Cardiac Differentiation of Pluripotent Stem Cells [0.03%]
用于多能干细胞心脏分化的small molecules的controlled release技术
Christopher J Tsao,Francesca Taraballi,Laura Pandolfi et al.
Christopher J Tsao et al.
Induced pluripotent stem cells (iPSCs) have been shown to differentiate to functional cardiomyocytes (CM) with high efficiency through temporally controlled inhibition of the GSK3/Wnt signaling pathways. In this study, we investigated the a...
Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage [0.03%]
人诱导多能干细胞来源软骨的整合能力
Xike Chen,Akihiro Yamashita,Miho Morioka et al.
Xike Chen et al.
Cartilage particles derived from human induced pluripotent stem cells (hiPS-Carts) are one candidate source for transplants for treatment of articular cartilage damage. This study shows that hiPS-Carts integrate with each other in an in vit...
Evaluation of Placental Mesenchymal Stem Cell Sheets for Myocardial Repair and Regeneration [0.03%]
胎盘间充质干细胞片在心肌修复和再生中的评估研究
Erin G Roberts,Breanna L Piekarski,Kevin Huang et al.
Erin G Roberts et al.
This work explores placental tissue as a cell source for fabrication of tissue-engineered surgical patches for myocardial repair of congenital heart defects. This study demonstrates promising findings for the clinically driven evaluation of...
The Osteoinductive Effect of Controlled Bone Morphogenic Protein 2 Release Is Location Dependent [0.03%]
生长因子诱导骨组织工程的定位效应研究
Maurits G L Olthof,Lichun Lu,Marianna A Tryfonidou et al.
Maurits G L Olthof et al.
The main challenge in bone morphogenic protein 2 (BMP-2)-based application lies in finding strategies to prolong its biologic activity as it has a short biological half-life. The present study uses a phosphate-modified oligo[(polyethylene g...
Preclinical Optimization of a Shelf-Ready, Injectable, Human-Derived, Decellularized Allograft Adipose Matrix [0.03%]
一种即用型人源同种异体脱细胞脂肪基质支架的临床前优化研究
Giorgio Giatsidis,Julien Succar,Anthony Haddad et al.
Giorgio Giatsidis et al.
Trauma, disease, surgery, or congentital defects can cause soft tissue losses in patients, leading to disfigurement, functional impairment, and a low quality of life. In the lack of available effective methods to reconstruct these defects, ...
Raman Deep Singh,Matthew L Hillestad,Christopher Livia et al.
Raman Deep Singh et al.
The M3RNA (microencapsulated modified messenger RNA) platform is an approach to deliver messenger RNA (mRNA) in vivo, achieving a nonintegrating and viral-free approach to gene therapy. This technology was, in this study, tested for its uti...