Therapeutic Effect of a Xeno-Free Three-Dimensional Stem Cell Mass in a Hind Limb Ischemia Model [0.03%]
一种无异种成分的三维干细胞团在下肢缺血模型中的治疗作用
Thanavel Rajangam,Kyoung-Sik Moon,Dokyun Kim et al.
Thanavel Rajangam et al.
We describe an innovative method of culturing a three-dimensional cell mass (3DCM) of human adipose-derived stem cells (hASCs) in the xeno-free (XF) condition for the treatment of severe ischemic diseases. The majority of the mice injected ...
Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury [0.03%]
含脊髓前体细胞的桥梁促进脊髓损伤后的轴突再生
Courtney M Dumont,Mary K Munsell,Mitchell A Carlson et al.
Courtney M Dumont et al.
Spinal cord injury (SCI) results in loss of tissue innervation below the injury. Spinal progenitors have a greater ability to repair the damage and can be injected into the injury, but their regenerative potential is hampered by their poor ...
A Functional Tissue-Engineered Synovium Model to Study Osteoarthritis Progression and Treatment [0.03%]
功能性的组织工程滑膜模型用于研究骨关节炎的进展和治疗效果
Robert M Stefani,Saiti S Halder,Eben G Estell et al.
Robert M Stefani et al.
The synovium envelops the diarthrodial joint and plays a key regulatory role in defining the composition of the synovial fluid through filtration and biosynthesis of critical boundary lubricants. Synovium changes often precede cartilage dam...
Augmentation Cystoplasty of Diseased Porcine Bladders with Bi-Layer Silk Fibroin Grafts [0.03%]
双层家蚕丝素移植物增强的猪膀胱原位组织工程化重建
Saif Affas,Frank-Mattias Schäfer,Khalid Algarrahi et al.
Saif Affas et al.
The search for an ideal "off-the-shelf" biomaterial for augmentation cystoplasty remains elusive and current scaffold configurations are hampered by mechanical and biocompatibility restrictions. In addition, preclinical evaluations of poten...
Noninvasive Localized Cold Therapy: A New Mode of Bone Repair Enhancement [0.03%]
非侵入性局部冷疗：一种新的骨修复增强模式
Daniel Castano,Marianne Comeau-Gauthier,Jose Luis Ramirez-GarciaLuna et al.
Daniel Castano et al.
A variety of biological, mechanical, and physical therapeutic modalities of varying complexity, efficacy, cost, and safety profile have been developed to enhance bone healing. There have been sporadic reports of spontaneous bone formation a...
Size-Dependent Cortical Compaction Induces Metabolic Adaptation in Mesenchymal Stem Cell Aggregates [0.03%]
尺寸依赖性的皮质紧缩促使间充质干细胞聚集物发生代谢适应性变化
Brent M Bijonowski,Susan I Daraiseh,Xuegang Yuan et al.
Brent M Bijonowski et al.
This study reveals that multicellular aggregation induces metabolic reprogramming via mechanical compaction in lieu of formation of a hypoxic core. Utilizing biomechanical knowledge gained from planar culture, we set forth a novel three-dim...
Composite Hydrogel Embedded with Porous Microspheres for Long-Term pH-Sensitive Drug Delivery [0.03%]
具有多孔微球的复合水凝胶用于长期pH敏感药物释放
Xifeng Liu,Kevin A Fundora,Zifei Zhou et al.
Xifeng Liu et al.
A composite hydrogel embedded with porous microspheres fabricated by phase separation methods was developed and showed excellent long-term anticancer drug delivery capability to cancer cells. ...
Therapeutic Effect of Controlled Release of Dual Growth Factor Using Heparin-Pluronic Hydrogel/Gelatin-Poly (Ethylene Glycol)-Tyramine Hydrogel System in a Rat Model of Cavernous Nerve Injury [0.03%]
基于肝素普鲁兰多糖水凝胶/明胶聚乙二醇右旋儿茶酚 tyramine 水凝胶的双生长因子缓释修复损伤海绵体神经的效果研究
Ae Ryang Jung,Yong Hyun Park,Seung Hwan Jeon et al.
Ae Ryang Jung et al.
The number of cases of erectile dysfunction (ED) caused after radical prostatectomy (RP) prostate cancer treatment is increasing steadily. Although various studies have been conducted for treatment of post-RP ED, there is still a need for m...
Sequential Zonal Chondrogenic Differentiation of Mesenchymal Stem Cells in Cartilage Matrices [0.03%]
基于软骨基质的间充质干细胞分区域序贯软骨分化研究
Seyedsina Moeinzadeh,Mehri Monavarian,Safaa Kader et al.
Seyedsina Moeinzadeh et al.
The higher regenerative capacity of fetal articular cartilage compared with the adult is rooted in differences in cell density and matrix composition. We hypothesized that the zonal organization of articular cartilage can be engineered by e...
Enhanced Hepatic Differentiation of Human Induced Pluripotent Stem Cells Using Gas-Permeable Membrane [0.03%]
气体渗透性膜促进的人诱导多能干细胞肝细胞分化能力的研究
Keiichi Kimura,Ikki Horiguchi,Taketomo Kido et al.
Keiichi Kimura et al.
Although oxygen is a vital nutrient for the hepatocytes in vitro, few reports have focused on its effect during hepatic differentiation of induced pluripotent stem cells (iPSCs). In this report, we performed the hepatic differentiation of h...