The Potential Chondrogenic Effect of Eucomis autumnalis Aqueous Extracts on Porcine Adipose-Derived Mesenchymal Stem Cells [0.03%]
欧告根提取物潜在诱导脂肪来源干细胞向软骨细胞分化的实验研究
Makwese Maepa,Cornelius Cano Ssemakalu,Keolebogile Shirley Motaung
Makwese Maepa
Eucomis autumnalis is one plant that is used by various traditional healers to alleviate the signs and symptoms associated with osteoarthritis. Although the exact mechanisms remain unknown, we hypothesized that this plant can induce chondro...
3D Coculture Models Underline Metastatic Melanoma Cell Sensitivity to Vemurafenib [0.03%]
三维共培养模型强调黑色素瘤细胞对维莫非尼的敏感性
Delphine Morales,Florian Lombart,Agathe Truchot et al.
Delphine Morales et al.
Three dimensional in vitro cell culture systems better reflect the native structural architecture of tissues and are attractive to investigate cancer cell sensitivity to drugs. We have developed and compared several metastatic melanoma (MM)...
Evaluation of Plastic-Compressed Collagen for Conjunctival Repair in a Rabbit Model [0.03%]
用于兔结膜修复的压缩型塑料-胶原蛋白膜的评估研究
Joana Witt,Maria Borrelli,Sonja Mertsch et al.
Joana Witt et al.
Conjunctival integrity is crucial for a healthy ocular surface and visual acuity. In severe cases of inflammatory surface disorders or after trauma, thermal or chemical burns as well as after ocular surgery, a surgical reconstruction using ...
Periodontal Tissue Regeneration Using Brain-Derived Neurotrophic Factor Delivered by Collagen Sponge [0.03%]
脑源性神经营养因子负载胶原海绵促进牙周组织再生的效果研究
Ilana Ramalho,Edmara Bergamo,Adolfo Lopes et al.
Ilana Ramalho et al.
The various roles played by brain-derived neurotrophic factor (BDNF) in a multitude of tissues and at different scenarios have rendered BDNF a favorable candidate for improving tissue regeneration. Although the tested formulations of BDNF q...
Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture [0.03%]
基质弹性决定肾脏管状上皮细胞长期培养中的分化方向
Harold D Love,Mingfang Ao,Seiver Jorgensen et al.
Harold D Love et al.
Successful clinical tissue engineering requires functional fidelity of the cultured cell to its in vivo counterpart, but this has been elusive in renal tissue engineering. Typically, renal proximal tubule cells in culture have a flattened m...
SOX- 6, 9-Transfected Adipose Stem Cells to Treat Surgically-Induced Osteoarthritis in Goats [0.03%]
转基因 SOX-6 和 SOX-9 的脂肪干细胞治疗山羊术后骨关节炎
Ji-Yun Ko,Jimin Lee,Jungsun Lee et al.
Ji-Yun Ko et al.
We developed SOX-6, 9-transfected human adipose stem cells (SOX-6, 9ASCs) to treat osteoarthritis (OA). SOX-6, 9-transfection led to in vitro chondrogenesis of adipose stem cells (ASCs) comparable to that achieved by growth factor treatment...
Effect of Dentin Matrix Components on the Mineralization of Human Mesenchymal Stromal Cells [0.03%]
牙本质基质成分对人源间充质干细胞矿化的影响
Xenos Petridis,Bas P Beems,Phillip L Tomson et al.
Xenos Petridis et al.
This research has been conducted with the aim to contribute to the development of treatment modalities for the reconstruction of lost/damaged mineralized tissues. Currently, determining the most appropriate stromal cell population and signa...
The Effect of Laminin-111 Hydrogels on Muscle Regeneration in a Murine Model of Injury [0.03%]
胶原酶诱导的肌损伤小鼠模型中I型胶原涂布的层粘连蛋白-111水凝胶对骨骼肌再生的影响
Madison Marcinczyk,Andrew Dunn,Gabriel Haas et al.
Madison Marcinczyk et al.
Extremity injuries make up the most common survivable injuries in vehicular accidents and modern military conflicts. A majority of these injuries involve volumetric muscle loss (VML). The potential for donor site morbidity may limit the cli...
Elizabeth R Balmayor,Christopher H Evans
Elizabeth R Balmayor
RNA has several theoretical advantages as a therapeutic agent, but exploiting RNA in this fashion has faced several major hurdles. Not only is it unstable and difficult to deliver across hydrophobic cell membranes, but extraneous RNA also a...
Decellularized Cortical Bone Scaffold Promotes Organized Neovascularization In Vivo [0.03%]
脱细胞骨支架促进体内有序血管化
Brittany Taylor,Sarah Indano,Yasonia Yankannah et al.
Brittany Taylor et al.
Bone loss and skeletal deficiencies due to musculoskeletal diseases, traumatic injury, abnormal development, and cancer are major problems worldwide, frequently requiring surgical intervention. There has been a shift in paradigm to utilize ...