Multisite Injection of Bioengineered Hepatic Units from Collagen Hydrogel and Neonatal Liver Cells in Parenchyma Improves Liver Cirrhosis [0.03%]
胶原水凝胶和新生儿肝细胞的多部位注射改善肝硬化
Yunshan Zhao,Bingbing Xu,Wentao Liang et al.
Yunshan Zhao et al.
Intrahepatic transplantation of hepatocytes/progenitor cells remodels or repopulates livers resulting in improved hepatic function, which represents a promising treatment option for liver diseases, but poor engraftment of transplanted liver...
Cyclic Strain Affects Macrophage Cytokine Secretion and Extracellular Matrix Turnover in Electrospun Scaffolds [0.03%]
cyclic strain影响电纺支架中巨噬细胞细胞因子分泌和细胞外基质周转
Valentina Bonito,Bente J de Kort,Carlijn V C Bouten et al.
Valentina Bonito et al.
Electrospun elastomeric scaffolds are being used for a variety of in situ tissue engineering applications, in which biomechanical loads play a dominant in vivo role, such as cardiovascular replacements (e.g., heart valve and blood vessel pr...
Hypoxia-Inducible Factor Drives Vascularization of Modularly Assembled Engineered Tissue [0.03%]
缺氧诱导因子驱动模块化组装工程组织的血管化
Gabrielle C Lam,Michael V Sefton
Gabrielle C Lam
Using two inhibitory methods, we demonstrated that hypoxia-inducible factor (HIF) plays an important role in vascularizing and oxygenating modularly-assembled engineered tissues. Each inhibitory technique elucidated a different mechanism by...
Stromal Cell-Derived Factor 1 Promotes Cell Migration to Enhance Bone Regeneration After Hypoxic Preconditioning [0.03%]
缺氧预处理后stromal细胞衍生因子1促进细胞迁移以增强骨再生
Jiaqi Huang,Hui Chi,Haiyang Chi et al.
Jiaqi Huang et al.
Current tissue engineering strategies have progressed recently from a historical approach that is based primarily on biomaterials to a cell- and tissue-based approach. Essentially all orthopedic tissue engineering strategies can be distille...
Biocompatibility and Immunogenicity of Decellularized Allogeneic Aorta in the Orthotopic Rat Model [0.03%]
异体去细胞主动脉正位移植大鼠模型的生物相容性和免疫原性研究
Michalis Katsimpoulas,Lucrezia Morticelli,Ioanna Gontika et al.
Michalis Katsimpoulas et al.
The generation of a small-caliber arterial graft, utilizing a large vessel of a small animal, such as the aorta of the rat or rabbit, for clinical use in the peripheral arterial tree, can widen the options for arterial prostheses. This in v...
Periostin and CCN2 Scaffolds Promote the Wound Healing Response in the Skin of Diabetic Mice [0.03%]
periostin和CCN2支架促进糖尿病小鼠皮肤伤口愈合反应
Christopher G Elliott,Jiarong Wang,John T Walker et al.
Christopher G Elliott et al.
Nonhealing skin wounds remain a significant burden on health care systems, with diabetic patients 20 times as likely to undergo a lower extremity amputation due to impaired healing. Novel treatments that suppress the proinflammatory signatu...
Regulation of the Distribution of Cells in Mixed Spheroids by Altering Migration Direction [0.03%]
通过改变迁移方向调节混合细胞球体内细胞分布
Yuya Mizukami,Yuki Takahashi,Kazunori Shimizu et al.
Yuya Mizukami et al.
Complex and functional artificial tissues consisting of multiple types of cells are generally required. However, few reliable methods to control the cellular distribution have been developed. Our present study has revealed how the core-shel...
Interleukin-37 Protects Stem Cell-Based Cartilage Formation in an Inflammatory Osteoarthritis-Like Microenvironment [0.03%]
白细胞介素37通过保护干细胞软骨形成来缓解滑膜炎诱导的类骨关节炎微环境损伤
Ellen Wilhelmina van Geffen,Arjan Petrus Maria van Caam,Elly Louise Vitters et al.
Ellen Wilhelmina van Geffen et al.
Catabolic factors present in a damaged joint inhibit chondrogenic differentiation of mesenchymal stem cells, thereby reducing the chance for successful cartilage formation. By improving stem cell-based cartilage repair with interleukin-37 (...
Engineered Heart Slice Model of Arrhythmogenic Cardiomyopathy Using Plakophilin-2 Mutant Myocytes [0.03%]
使用Plakophilin-2突变心肌细胞构建心律失常性心肌病工程心脏切片模型
Adriana Blazeski,Justin Lowenthal,Yin Wang et al.
Adriana Blazeski et al.
Genetic heart diseases such as arrhythmogenic cardiomyopathy (AC), a common genetic cause of sudden cardiac death, can be modeled using patient-specific induced pluripotent stem cell-derived cardiac myocytes (CMs). However, it is important ...
Regulating Osteogenic Differentiation by Suppression of Exosomal MicroRNAs [0.03%]
通过抑制外泌体微小RNA调节成骨分化
Song-Yi Choi,Eun-Chong Han,Su-Hyung Hong et al.
Song-Yi Choi et al.
We investigated the role of exosomes in osteogenesis and the use of miRNA inhibitor-transfected exosomes to control osteogenic differentiation. RNA-sequencing (RNA-seq) of exosomal miRNAs revealed that growth condition of milieu of preosteo...