Kolja Gelse,Jonas Biggemann,Martin Stumpf et al.
Kolja Gelse et al.
The repair of large articular cartilage lesions is still a major challenge. In particular, the fixation of the grafts to the subchondral bone plate represents an unresolved problem. In this work, we present a completely novel concept based ...
A Method for High-Throughput Robotic Assembly of Three-Dimensional Vascular Tissue [0.03%]
一种高通量的三维血管组织机器人组装方法
Christopher J Nycz,Hannah A Strobel,Kathy Suqui et al.
Christopher J Nycz et al.
Self-assembled tissues have potential to serve both as implantable grafts and as tools for disease modeling and drug screening. For these applications, tissue production must ultimately be scaled-up and automated. Limited technologies exist...
Three-Dimensional Culture of Salivary Gland Stem Cell in Orthotropic Decellularized Extracellular Matrix Hydrogels [0.03%]
唾液腺干细胞在正向脱细胞基底外基质水凝胶中的三维培养
Kyungshin Shin,Kyung Hee Koo,Jaemin Jeong et al.
Kyungshin Shin et al.
Radiotherapy in patients with cancer can kill cancer cells but also damage normal cells or tissues. During the treatment of patients with head and neck cancer or thyroid cancer, hyposalivation is a representative chronic side effect of radi...
Impact of Hydrogel Stiffness on Differentiation of Human Adipose-Derived Stem Cell Microspheroids [0.03%]
透明质胶刚度对人脂肪来源干细胞微球分化的影响研究
Sara Žigon-Branc,Marica Markovic,Jasper Van Hoorick et al.
Sara Žigon-Branc et al.
Hydrogels represent an attractive material platform for realization of three-dimensional (3D) tissue-engineered constructs, as they have tunable mechanical properties, are compatible with different types of cells, and resemble elements foun...
Electrospun Nanofibers with Core-Shell Structure for Treatment of Bladder Regeneration [0.03%]
具有核壳结构的静电纺纳米纤维用于膀胱再生治疗
Chunxiang Feng,Chang Liu,Shiliang Liu et al.
Chunxiang Feng et al.
The extracellular matrix (ECM)-inspired electrospinning scaffolds have a good cytocompatibility. Hyaluronic acid (HA) is one of the main components in the bladder ECM, but it is hard to be made by electrospinning alone. In this study, it is...
Quantifying the Vasculogenic Potential of Induced Pluripotent Stem Cell-Derived Endothelial Progenitors in Collagen Hydrogels [0.03%]
胶原水凝胶中诱导多能干细胞来源内皮前体细胞成血管潜能的量化研究
Cody O Crosby,Deepti Valliappan,David Shu et al.
Cody O Crosby et al.
Our work reinforces the role of extracellular matrix (ECM) density and matrix metalloprotease activity on the formation of microvasculature from induced pluripotent stem cell (iPSC)-derived vascular cells. The cell-matrix interactions discu...
Effect of Biomaterial Electrical Charge on Bone Morphogenetic Protein-2-Induced In Vivo Bone Formation [0.03%]
生物材料电荷对骨形态发生蛋白-2诱导成骨的作用
Maurits G L Olthof,Diederik H R Kempen,Xifeng Liu et al.
Maurits G L Olthof et al.
Biomaterials can play a dual role in bone regeneration: they enable local sustained delivery of growth factors, such as bone morphogenetic protein-2 (BMP-2), while they provide structural support as scaffold. By better imitating the propert...
S53P4 Bioactive Glass Inorganic Ions for Vascularized Bone Tissue Engineering by Dental Pulp Pluripotent-Like Stem Cell Cocultures [0.03%]
用于血管化骨组织工程的牙髓多能类干细胞共培养释放的生物活性玻璃无机离子
Raquel Núñez-Toldrà,Sheyla Montori,Begoña Bosch et al.
Raquel Núñez-Toldrà et al.
In this study, we proposed for the first time the use of inorganic ions dissolved from BaG in a cell coculture system to induce vascularized bone formation in vitro. For that, we used dental pulp pluripotent-like stem cells from a single in...
Richard Meeson,Anita Sanghani-Keri,Melanie Coathup et al.
Richard Meeson et al.
Currently ∼10% of fractures progress to delayed or nonunion with significant morbidity and economic impact. Endogenous mobilization of stem cells by pharmacological antagonism of their homing and migration receptor CXCR4 with AMD3100 exper...
Local Delivery of Brain-Derived Neurotrophic Factor Enables Behavioral Recovery and Tissue Repair in Stroke-Injured Rats [0.03%]
脑源性神经营养因子局部给药可促进卒中大鼠行为恢复和组织修复
Jaclyn M Obermeyer,Anup Tuladhar,Samantha L Payne et al.
Jaclyn M Obermeyer et al.
We developed a biocomposite that can be mixed with brain-derived neurotrophic factor (BDNF) and dispensed onto the surface of the brain to provide sustained, local release of the protein using a procedure that avoids additional damage to ne...