Human Recellularization for Xenoantigen-Free Decellularized Cardiac Xenografts [0.03%]
人源化技术去除异种心脏移植物中的异种抗原
Ja-Kyoung Yoon,So Young Kim,Serin Kim et al.
Ja-Kyoung Yoon et al.
Removal of major xenoantigens of the Galα1-3Gal (α-Gal) epitope and the nonhuman sialic acid N-glycolylneuraminic acid (Neu5Gc) is essential to eliminate xenoimmunogenicity and optimize recellularization for cardiac xenografts. The aim of...
Tissue-Engineered Nerve Grafts: Material Innovations and Clinical Translation Challenges [0.03%]
组织工程神经移植物：材料创新与临床转化挑战
Huan Lian,Yalu Wang,Qianqian Han et al.
Huan Lian et al.
Peripheral nerve injury (PNI) is a common disabling condition primarily caused by trauma, such as traffic accidents and occupational injuries. Traditional treatments for PNI have significant limitations. Tissue-engineered nerve grafts (TENG...
Influence of Scaffold Topography and Culture Duration on Fibroblast Morphology in Tissue Engineering [0.03%]
组织工程中支架形貌和培养时间对成纤维细胞形态的影响
Maria I Echeverria Molina,Kyriakos Komvopoulos
Maria I Echeverria Molina
Cell morphology is not only integral to its function within the body but also plays a critical role in cellular behavior and fate. In tissue engineering, cell-scaffold interactions play a critical role because scaffold physical and biochemi...
Induction of M2 Macrophages by Fibrin Hydrogels Enhances Bone Regeneration [0.03%]
纤维蛋白水凝胶诱导的M2型巨噬细胞促进骨再生
Ryosuke Aihara,Kazumasa Murata,Tomo Unzai et al.
Ryosuke Aihara et al.
Bone regeneration remains a significant challenge in regenerative medicine. In this context, fibrin hydrogels have attracted attention as a promising biomaterial that regulates the inflammatory response and promotes tissue repair by influen...
Scaffold-Free Osteochondral Engineering Using Embryonic-Derived Mesenchymal Stem Cell Spheroids [0.03%]
无支架软骨组织工程化构建及胚胎源间充质干细胞球体的分化研究
Shawn P Grogan,Nicholas E Glembotski,Erik W Dorthé et al.
Shawn P Grogan et al.
In this study, we explored whether embryonic stem cell-derived mesenchymal stem cell (ES-MSC) cellular spheroids in combination with a closed chamber system could be used to create scaffold-free cartilage and endochondral graft tissues. ES-...
Amino Acids Enhance the Effects of Dexamethasone on Osteogenesis by Rat Stem Cells [0.03%]
氨基酸通过大鼠干细胞增强地塞米松的促骨形成作用研究
Hitomi Nakama,Nozomi Matsuo,Ayano Miyamoto et al.
Hitomi Nakama et al.
Dental pulp tissue is a desirable cell source for tooth regeneration. However, the extirpation of dental pulp tissue from the tooth root canal causes a partial defect in a sound tooth, which is unacceptable, even for the purpose of tooth re...
Bone Organoids: Bridging Natural Bone with Advanced Organoid Technologies [0.03%]
骨器官体：天然骨骼与高级器官体技术的桥梁
Kaige Mao,Yifan Wang,Sengpav Tong et al.
Kaige Mao et al.
Bone tissue engineering has long been a focal point of research, aiming to address critical large segmental bone defects resulting from severe trauma, tumors, and other bone-related diseases. Despite significant advancements in conventional...
Disc-Derived Induced Pluripotent Stem Cells and Environmental Cues for Nucleus Pulposus Regeneration [0.03%]
基于光盘衍生的诱导多能干细胞和环境线索的椎间盘髓核再生
Lisanne T Laagland,Deepani W L Poramba Liyanage,Romain Desprat et al.
Lisanne T Laagland et al.
Notochordal cells (NCs), abundantly found in the developing nucleus pulposus (NP), show potential for intervertebral disc regeneration because of their unique instructive and healthy matrix-producing capacity. However, NCs are lost early in...
In Vitro Model Extracellular Matrix Maturation Under Variable Stress Conditions [0.03%]
变应力条件下的体外细胞外基质成熟模型
Christian A Boehm,Mahmoud Sesa,Vytautas Kucikas et al.
Christian A Boehm et al.
The study aims to enhance the design process of tissue-engineered implants by evaluating the effects of scaffold reinforcement and cultivation conditions on extracellular matrix (ECM) development. The research investigates the hypothesis th...
Harnessing Immunomodulation: How Calcium Phosphate Biomaterials Orchestrate Bone Regeneration [0.03%]
调控免疫反应：钙磷生物材料有序引导骨再生
Mengyuan Zhang,Ben Wan,Mouyuan Sun et al.
Mengyuan Zhang et al.
The immune system and biomaterials exhibit a well-documented synergistic interplay, essential for bone defect healing. Calcium phosphate (CaP) biomaterials, notably hydroxyapatite, β-tricalcium phosphate, and biphasic calcium phosphate, ar...