LINGO-1 shRNA Loaded by Pluronic F-127 Promotes Functional Recovery After Ventral Root Avulsion [0.03%]
聚氧乙烯-p-聚氧丙烯-p-聚氧乙烯三嵌段共聚物F-127载Lingo-1小干扰RNA促进马尾神经根撕脱后功能恢复
Lu Ding,Zhe Zhu,Yuhui Wang et al.
Lu Ding et al.
Spinal root avulsion typically leads to massive motoneuron death and severe functional deficits of the target muscles. Multiple pathological factors such as severe neuron loss, induction of inhibitory molecules, and insufficient regeneratio...
Adipose Stem Cells Enhance Nerve Regeneration and Muscle Function in a Peroneal Nerve Ablation Model [0.03%]
脂肪干细胞通过促进神经再生和肌肉功能恢复改善胫神经切除模型中小鼠的步态参数
Juliana A Passipieri,Jack Dienes,Joseph Frank et al.
Juliana A Passipieri et al.
Severe peripheral nerve injuries have devastating consequences on the quality of life in affected patients, and they represent a significant unmet medical need. Destruction of nerve fibers results in denervation of targeted muscles, which, ...
Magnetic Tissue Engineering of the Vocal Fold Using Superparamagnetic Iron Oxide Nanoparticles [0.03%]
使用超顺磁性氧化铁纳米颗粒进行声带组织工程的磁场调控
Marina Pöttler,Anna Fliedner,Julia Bergmann et al.
Marina Pöttler et al.
Losing one's ability to speak, because of tissue deficiency at the vocal fold (VF), leads to serious impairment in the quality of life. Until now, there is no successful approach for regenerating the VF. The aim of this study was to show th...
A Reporter System Evaluates Tumorigenesis, Metastasis, β-catenin/MMP Regulation, and Druggability [0.03%]
一种报道系统评估肿瘤发生、转移、β-连环蛋白/mmp调节和药物靶点可行性
Chiharu Sogawa,Takanori Eguchi,Yuka Okusha et al.
Chiharu Sogawa et al.
Cancer invasion, metastasis, and therapy resistance are the crucial phenomena in cancer malignancy. The high expression of matrix metalloproteinase 9 (MMP9) is a biomarker as well as a causal factor of cancer invasiveness and metastatic act...
Comparison of Stromal Vascular Fraction and Passaged Adipose-Derived Stromal/Stem Cells as Point-of-Care Agents for Bone Regeneration [0.03%]
比较基质血管部分和传代脂肪来源基质/干细胞作为骨再生即时使用的生物材料
Ethan Nyberg,Ashley Farris,Aine O&#x;Sullivan et al.
Ethan Nyberg et al.
Large craniofacial bone defects remain a clinical challenge due to their complex shapes and large volumes. Stem cell-based technologies that deliver osteogenic stem cells have shown remarkable regenerative potential but are hampered by the ...
Comparative Study
Tissue engineering. Part A. 2019 Nov;25(21-22):1459-1469. DOI:10.1089/ten.TEA.2018.0341 2019
A Scaffold- and Serum-Free Method to Mimic Human Stable Cartilage Validated by Secretome [0.03%]
一种无支架、无血清模拟人类稳定软骨的方法并由分泌组验证
Isis Côrtes,Renata A M Matsui,Mayra S Azevedo et al.
Isis Côrtes et al.
A stabilized cartilage construct without signs of hypertrophy in chondrocytes is still a challenge. Suspensions of adipose stem/stromal cells (ASCs) and cartilage progenitor cells (CPCs) were seeded into micromolded nonadhesive hydrogel to ...
Temporal Impact of Substrate Anisotropy on Differentiating Cardiomyocyte Alignment and Functionality [0.03%]
基底物各向异性对心肌细胞排列和功能的时序影响研究
Alicia C B Allen,Elissa Barone,Nima Momtahan et al.
Alicia C B Allen et al.
Anisotropic biomaterials can affect cell function by driving cell alignment, which is critical for cardiac engineered tissues. Recent work, however, has shown that pluripotent stem cell-derived cardiomyocytes may self-align over long period...
Bone Regeneration by Controlled Release of Bone Morphogenetic Protein-2: A Rabbit Spinal Fusion Chamber Molecular Study [0.03%]
调控释放骨形态蛋白-2的椎间融合器促进骨再生：分子生物学研究模型兔脊柱融合间隙实验
Tao Hu,Mathanapriya Naidu,Zheng Yang et al.
Tao Hu et al.
Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been widely used in spine fusion surgery. However, high doses of rhBMP-2 delivered with absorbable collagen sponge (ACS) have led to inflammation-related adverse conditions. Polye...
Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering [0.03%]
追根溯源：组织工程研究向临床转化的25年路程
Tyler Hoffman,Ali Khademhosseini,Robert Langer
Tyler Hoffman
In this Perspective, we discuss the impact of the past 25 years of tissue engineering on the development of clinical therapies. Based on their success and other significant research accomplishments, platforms of innovation were identified. ...
CRISPR/Cas9 Edited Induced Pluripotent Stem Cell-Based Vascular Tissues to Model Aging and Disease-Dependent Impairment [0.03%]
基于CRISPR/Cas9编辑的诱导多能干细胞构建血管组织模型年龄和疾病相关功能障碍
Aylin Acun,Pinar Zorlutuna
Aylin Acun
Modeling human disease as precisely as possible is of upmost importance in understanding the underlying pathology and discovering effective therapies. Therefore, disease models that are highly controlled and composed of human-origin cells t...