Reduced Size Profile of Amniotic Membrane Particles Decreases Osteoarthritis Therapeutic Efficacy [0.03%]
绒毛膜颗粒大小对其治疗骨关节炎疗效的影响
David S Reece,Olivia A Burnsed,Kaley Parchinski et al.
David S Reece et al.
Osteoarthritis (OA) is a widespread disease that continues to lack approved and efficacious treatments that modify disease progression. Micronized dehydrated human amnion/chorion membrane (μ-dHACM) has been shown to be effective in reducin...
Hypoxia-Preconditioned Adipose-Derived Endothelial Progenitor Cells Promote Bladder Augmentation [0.03%]
缺氧预处理的脂肪来源内皮前体细胞促进膀胱扩容手术后尿路新血管形成及组织修复作用
Feng Zhao,Liuhua Zhou,Zhongle Xu et al.
Feng Zhao et al.
Tissue engineering technology provides an alternative for bladder reconstruction, which remains confronted with challenges, such as insufficient vascularization in regenerated bladder tissue. Short-term hypoxic preconditioning has been repo...
Enzyme Pretreatment plus Locally Delivered HB-IGF-1 Stimulate Integrative Cartilage Repair In Vitro [0.03%]
酶预处理结合局部递送HB-IGF-1刺激软骨组织整合修复
Paul H Liebesny,Keri Mroszczyk,Hannah Zlotnick et al.
Paul H Liebesny et al.
A critical attribute for the long-term success of cartilage defect repair is the strong integration between the repair tissue and the surrounding native tissue. Current approaches utilized by physicians fail to achieve this attribute, leadi...
Continuous Low-Intensity Ultrasound Promotes Native-to-Native Cartilage Integration [0.03%]
连续低强度超声波促进软骨原生组织整合
Neety Sahu,April Miller,Hendrik J Viljoen et al.
Neety Sahu et al.
Failure of the host/graft interface to integrate impedes the success of cartilage repair protocols. Continuous low-intensity ultrasound (cLIUS) at the resonant frequency of 5 MHz is proposed as a treatment modality for promoting native-to-n...
Alicia J El Haj
Alicia J El Haj
Translation of regenerative therapies to the patient-bench-to-bedside-is one of the global multidisciplinary challenges of our time. New cell-based therapies are reaching the clinic through staged trials leading eventually to routine adopti...
The Behavior of Tendon Progenitor Cells from Tendinopathic Tendons: Implications for Treatment [0.03%]
肌腱病肌腱中的腱前体细胞的行为：对治疗的启示
Wenteh Chang,Kylie T Callan,Jason L Dragoo
Wenteh Chang
Tendinopathy remains a significant clinical challenge. Although there is some evidence that leukocyte-rich platelet-rich plasma can improve the symptoms of tendinopathy, more efficacious treatments will be required in the future to improve ...
Three-Dimensional Printed Polycaprolactone Scaffolds for Bone Regeneration Success and Future Perspective [0.03%]
三维打印聚己内酯骨再生支架的成功及其未来展望
Swee-Hin Teoh,Bee-Tin Goh,Jing Lim
Swee-Hin Teoh
Cells need a home to proliferate and remodel; biomimicry of the microarchitecture and microenvironment is important, and with 10 years of history in more than 20,000 clinical applications of 3D printed medical grade polycaprolactone scaffol...
Regenerative Repair of Volumetric Muscle Loss Injury is Sensitive to Age [0.03%]
体积肌肉损失损伤的再生修复易受年龄影响
John T Kim,Benjamin Kasukonis,Grady Dunlap et al.
John T Kim et al.
In this study, the influence of age on effectiveness of regenerative repair for the treatment of volumetric muscle loss (VML) injury was explored. Tibialis anterior (TA) VML injuries were repaired in both 3- and 18-month-old animal models (...
Heparan Sulfate Mimetics Accelerate Postinjury Skeletal Muscle Regeneration [0.03%]
肝素硫酸盐模拟物可加速损伤后骨骼肌再生
Jessica Bouvière,Aurélie Trignol,Dieu-Huong Hoang et al.
Jessica Bouvière et al.
Although skeletal muscle is capable of complete recovery after an injury, specific situations require support or acceleration of this process, such as in the elderly and athletes, respectively. Skeletal muscle regeneration is due to muscle ...
Amorphous Silicon Oxynitrophosphide-Coated Implants Boost Angiogenic Activity of Endothelial Cells [0.03%]
非晶硅氧化氮磷化合物涂层植入物可增强内皮细胞的血管生成活性
Felipe A do Monte,Kamal R Awad,Neelam Ahuja et al.
Felipe A do Monte et al.
Lack of osteointegration is a major cause of aseptic loosening and failure of implants used in bone replacement. Implants coated with angiogenic biomaterials can improve osteointegration and potentially reduce these complications. Silicon- ...