Three Dimensional Bioprinting of a Vascularized and Perfusable Skin Graft Using Human Keratinocytes, Fibroblasts, Pericytes, and Endothelial Cells [0.03%]
一种生物三维打印的人工皮肤移植片及其灌注实验：黑素细胞、角质形成细胞、成纤维细胞、周细胞及内皮细胞的共培养体系建立及相关性能评价
Tânia Baltazar,Jonathan Merola,Carolina Catarino et al.
Tânia Baltazar et al.
Multilayered skin substitutes comprising allogeneic cells have been tested for the treatment of nonhealing cutaneous ulcers. However, such nonnative skin grafts fail to permanently engraft because they lack dermal vascular networks importan...
Creation of Laryngeal Grafts from Primary Human Cells and Decellularized Laryngeal Scaffolds [0.03%]
基于人声门原代细胞和脱细胞声门支架的声带移植物构建
Philipp T Moser,Mattia Gerli,Gillian R Diercks et al.
Philipp T Moser et al.
Current reconstruction methods of the laryngotracheal segment fail to replace the complex functions of the human larynx. Bioengineering approaches to reconstruction have been limited by the complex tissue compartmentation of the larynx. We ...
Engineered Cartilage from Human Chondrocytes with Homozygous Knockout of Cell Cycle Inhibitor p21 [0.03%]
源于细胞周期抑制因子p21纯合敲除的人软骨细胞的工程化软骨研究
Susan D&#x;Costa,Matthew J Rich,Brian O Diekman
Susan D&#x;Costa
Osteoarthritis (OA) is a highly prevalent disease with limited treatment options. The search for disease-modifying OA therapies would benefit from a more comprehensive knowledge of the genetic variants that contribute to chondrocyte dysfunc...
Injectable Silk-Based Hydrogel as an Alternative to Cervical Cerclage: A Rabbit Study [0.03%]
一种用于宫颈环扎术的可注射丝蛋白水凝胶(兔实验)
Yali Zhang,Nicole Raia,Ashley Peterson et al.
Yali Zhang et al.
Background: Preterm birth is a common cause of morbidity and mortality in newborn infants. Cervical insufficiency (CI) is a significant cause of preterm birth. The treatment for CI is cerclage, which is a suture placed around the cervix to ...
The Effect of Mesenchymal Stem Cell Sheets on Early Healing of the Achilles Tendon in Rats [0.03%]
大鼠肌腱MSCsheets修复跟腱缺损的效果研究
Masahiro Maruyama,Le Wei,Timothy Thio et al.
Masahiro Maruyama et al.
Bone marrow-derived mesenchymal stem cells (BMSCs) have potential to accelerate flexor tendon healing and allow for earlier rehabilitation. The ideal BMSC construct and delivery method to the repair site remains unknown. We investigated the...
Long-Term Evaluation of Functional Outcomes Following Rat Volumetric Muscle Loss Injury and Repair [0.03%]
体积肌肉损失损伤与修复后的长期功能评估结果
Ellen L Mintz,Juliana A Passipieri,Isabelle R Franklin et al.
Ellen L Mintz et al.
Volumetric muscle loss (VML) injuries, by definition, exceed the endogenous repair capacity of skeletal muscle resulting in permanent structural and functional deficits. VML injuries present a significant burden for both civilian and milita...
BMP-3 Promotes Matrix Production in Co-cultured Stem Cells and Disc Cells from Low Back Pain Patients [0.03%]
BMP-3促进取自腰痛患者的间充质干细胞与椎间盘细胞共培养体系中基质的合成
Daphne Hingert,Helena Barreto Henriksson,Adad Baranto et al.
Daphne Hingert et al.
Low back pain is one of the most common disorders and believed to be due to intervertebral disc degeneration. Transplantation of human mesenchymal stem cells (hMSCs) is suggested as potential treatment option. Bone morphogenetic growth fact...
Exogenous Keratinocyte Growth Factor Is Not Required for Pigmentation of Skin Substitutes with Three Isogeneic Cell Types [0.03%]
外源角蛋白生长因子并非异基因皮肤移植物色素沉着所必需
Steven T Boyce,Dorothy M Supp,Christopher M Lloyd
Steven T Boyce
Engineered skin substitutes (ESS) containing human fibroblasts (hF) and human keratinocytes (hK) provide significant medical benefits for treatment of acute and chronic skin wounds, including, but not limited to, burns, burn scars, congenit...
Endothelial/Mesenchymal Stem Cell Crosstalk Within Bioprinted Cocultures [0.03%]
生物打印共培养物中内皮/间充质干细胞的相互作用
Marco Santoro,Tolulope O Awosika,Kirstie L Snodderly et al.
Marco Santoro et al.
The development of viable tissue surrogates requires a vascular network that sustains cell metabolism and tissue development. The coculture of endothelial cells (ECs) and mesenchymal stem cells (MSCs), the two key players involved in blood ...
Peptide-Based Scaffolds for the Culture and Transplantation of Human Dopaminergic Neurons [0.03%]
基于肽的培养基和多巴胺能神经元移植的人类神经元支架
Nicola L Francis,Nanxia Zhao,Hannah R Calvelli et al.
Nicola L Francis et al.
Cell replacement therapy is a promising treatment strategy for Parkinson's disease (PD); however, the poor survival rate of transplanted neurons is a critical barrier to functional recovery. In this study, we used self-assembling peptide na...