Microvessel Network Formation and Interactions with Pancreatic Islets in Three-Dimensional Chip Cultures [0.03%]
三维芯片培养中的微血管网络形成及与胰岛的相互作用
Mia H Rambøl,Edward Han,Laura E Niklason
Mia H Rambøl
The pancreatic islet is a highly vascularized micro-organ, and rapid revascularization postislet transplantation is important for islet survival and function. However, the various mechanisms involved in islet revascularization are not fully...
Miguel Angel Martin-Piedra,Antonio Santisteban-Espejo,Jose Antonio Moral-Munoz et al.
Miguel Angel Martin-Piedra et al.
Number of publications has been widely used as a measure of research output, especially academic and university research. Number of publications in tissue engineering (TE) has increased year by year since early 1990s. However, after an expo...
Influence of Damage-Associated Molecular Patterns from Chondrocytes in Tissue-Engineered Cartilage [0.03%]
软骨细胞释放的损伤相关分子模式在组织工程化软骨中的作用
Yuko Fujihara,Takahiro Abe,Yukiyo Asawa et al.
Yuko Fujihara et al.
To obtain stable outcomes in regenerative medicine, the quality of cells for transplantation is of great importance. Cellular stress potentially results in the release of damage-associated molecular patterns (DAMPs) and activates immunologi...
Investigation on Ciliary Functionality of Different Airway Epithelial Cell Lines in Three-Dimensional Cell Culture [0.03%]
三维细胞培养中不同呼吸道上皮细胞系纤毛功能的探究
Nina Lodes,Katharina Seidensticker,Alexander Perniss et al.
Nina Lodes et al.
Three-dimensional respiratory tissue models have been generated using, for example, human primary airway epithelial cells (hAEC) or respective cell lines. To investigate ciliopathies, such as primary ciliary dyskinesia, the presence of func...
Multimaterial Dual Gradient Three-Dimensional Printing for Osteogenic Differentiation and Spatial Segregation [0.03%]
用于成骨分化的双梯度生物打印材料及空间隔离效应研究
Brandon T Smith,Sean M Bittner,Emma Watson et al.
Brandon T Smith et al.
In this study of three-dimensional (3D) printed composite β-tricalcium phosphate (β-TCP)-/hydroxyapatite/poly(ɛ-caprolactone)-based constructs, the effects of vertical compositional ceramic gradients and architectural porosity gradients ...
Human Stem Cell-derived Aggregates of Forebrain Astroglia Respond to Amyloid Beta Oligomers [0.03%]
人干细胞来源的大脑皮层星形胶质细胞聚集物对淀粉样蛋白聚体的反应
Kyle Griffin,Julie Bejoy,Liqing Song et al.
Kyle Griffin et al.
Astrocytes are vital components in neuronal circuitry and there is increasing evidence linking the dysfunction of these cells to a number of central nervous system diseases. Studying the role of these cells in human brain function in the pa...
Spleen Organoid Units Generate Functional Human and Mouse Tissue-Engineered Spleen in a Murine Model [0.03%]
脾脏器官样单元产生功能性的人和小鼠组织工程脾脏：小鼠模型研究
Kristin Gee,Mubina A Isani,Alexa Fode et al.
Kristin Gee et al.
Introduction: Splenectomy is common after trauma or hematologic disease, and alters immune protection against pathogens, which may lead to fulminant infection with high mortality. Yet the spleen has demonstrable regenerative capacity and ce...
Wnt-Notch Signaling Interactions During Neural and Astroglial Patterning of Human Stem Cells [0.03%]
人干细胞神经和星形胶质细胞形态形成过程中Wnt-Notch信号通路的相互作用
Julie Bejoy,Brent Bijonowski,Mark Marzano et al.
Julie Bejoy et al.
The human brain formation involves complicated processing, which is regulated by a gene regulatory network influenced by different signaling pathways. The cross-regulatory interactions between elements of different pathways affect the proce...
Controlled Heterotypic Pseudo-Islet Assembly of Human β-Cells and Human Umbilical Vein Endothelial Cells Using Magnetic Levitation [0.03%]
利用磁力操控技术构建人β细胞与人脐静脉内皮细胞异质伪胰岛细胞团
Max Urbanczyk,Aline Zbinden,Shannon L Layland et al.
Max Urbanczyk et al.
β-Cell functionality and survival are highly dependent on the cells' microenvironment and cell-cell interactions. Since the pancreas is a highly vascularized organ, the crosstalk between β-cells and endothelial cells (ECs) is vital to ens...
Biomaterial-Guided Recombinant Adeno-associated Virus Delivery from Poly(Sodium Styrene Sulfonate)-Grafted Poly(ɛ-Caprolactone) Films to Target Human Bone Marrow Aspirates [0.03%]
一种多钠苯磺酸接枝聚乙交酯薄膜介导的重组腺相关病毒向人体骨髓定向递送生物材料指导的重组腺相关病毒递送
Jagadeesh K Venkatesan,Céline Falentin-Daudré,Amélie Leroux et al.
Jagadeesh K Venkatesan et al.
Scaffold-guided gene transfer offers strong systems to develop noninvasive convenient therapeutic options for the treatment of articular cartilage defects, especially when targeting bone marrow aspirates from patients containing chondrorege...