VEGF-A-Mediated Differentiation of Gingival Stem Cells to Endothelial Progenitor-Like Cells [0.03%]
血管内皮生长因子A介导的牙龈间充质干细胞向类似内皮祖细胞分化
Garima Gupta,Sandos Alghamdi,Alaa Redwan et al.
Garima Gupta et al.
The clinical success of bone regeneration relies on developing a functional, vascularized bone. Insufficient vascularization of tissue constructs remains a challenge in stem cell-based approaches, leading to poor graft integration and necro...
Glutamate Drives Glioblastoma Invasion in Three-Dimensional Hyaluronic Acid Hydrogels [0.03%]
谷氨酸驱动胶原酸水凝胶中胶质母细胞瘤的侵袭作用
Dana Wilkins,Sanjay Kumar
Dana Wilkins
Glioblastoma (GBM) tumors are characterized by an excess of extracellular glutamate, one important source of which is the tumor cells themselves. This abundance of glutamate promotes GBM proliferation, migration, and therapeutic resistance,...
3D Printing of Bioactive Glass-Poly(ε-Caprolactone) Scaffolds for Patient-Specific Bone Implants [0.03%]
用于个性化骨移植的生物活性玻璃-聚己内酯支架的三维打印技术研究进展
Jin-Oh Jeong,Young-Wook Moon,Dong-Ryul Song et al.
Jin-Oh Jeong et al.
Craniofacial bone reconstruction presents significant clinical challenges due to the region's complex anatomy and the need to restore both structural integrity and aesthetic function. This study aimed to enhance bone regeneration at graft s...
DPSC-EVs Drive Functional Recovery in Sjögren's Disease by Systemic Immunomodulation [0.03%]
DPSC-EVs通过全身免疫调节促进Sjögren病的功能恢复
Tatsuya Kawado,Kenichi Ogata,Masafumi Moriyama et al.
Tatsuya Kawado et al.
Sjögren's disease (SjD) is a debilitating autoimmune disorder characterized by progressive salivary gland destruction, for which current therapies are merely palliative. Novel therapeutic approaches focusing on immunomodulation are therefo...
A New Bioprinted Dual-Layered Corneal Structure Using Collagen-Based Bioinks [0.03%]
一种新的双层生物打印角膜结构，使用基于胶原蛋白的生物墨水
Huasheng Huang,Yunong Yuan,Yuan Fang et al.
Huasheng Huang et al.
Bioengineered corneal constructs are a promising solution to the global shortage of donor tissue. However, most current models lack anatomical curvature and appropriate extracellular matrix (ECM) composition of the native cornea, limiting t...
Omics Reveals Signaling-Associated Traits of Extracellular Vesicles Derived from Dental Stem Cells [0.03%]
组学揭示牙髓干细胞来源外泌体的信号特征
Miao Wang,Wai Man Tong,Shuyu Ma et al.
Miao Wang et al.
Stem cell-derived extracellular vesicles (EVs) play a crucial role in intercellular communication and reflect the functional characteristics of their parent cells. Despite the significant therapeutic potential of these EVs, the molecular fe...
Impact of Donor Age and Prolonged Warm Ischemia in Normothermic Machine Perfusion of Rat Livers [0.03%]
常温机械灌注下供肝捐献者年龄和长延时热缺血对大鼠肝脏移植影响的实验研究
Anna Sophia Pietsch,Leonard Boerger,Luca Padoan et al.
Anna Sophia Pietsch et al.
Background: Expanding the liver donor pool increasingly depends on extended criteria donors (ECD), including older individuals and those after circulatory death. However, ECD grafts are more susceptible to ischemia-reperf...
Adhesive Hydrogel Inks with Boronic Acid-Cis-Diol Complexation for On-Muscle Printing [0.03%]
用于肌体内印刷的含硼酸-顺式二醇配位的粘性水凝胶墨水
Jaebeom Lee,Sumin Lee,Seung Hyun Lee et al.
Jaebeom Lee et al.
For addressing the challenges regarding muscle injuries, 3D printing has been a promising technique to fabricate patient-specific scaffolds and effectively guide myotube alignment. Although methacrylate-conjugated gelatin (GelMA) is widely ...
Generation of 3D Liver Microtissues from Induced Pluripotent Stem Cells [0.03%]
基于诱导多能干细胞的三维肝类器官培养方法
Jungchan Han,Jaemin Jeong
Jungchan Han
The liver is a multifunctional organ essential for detoxification, protein synthesis, glucose regulation, bile secretion, and drug metabolism. However, persistent damage leads to chronic inflammation, excessive extracellular matrix depositi...
Platelet-Rich Plasma Hydrogel Patch Promotes Hyperacute Cardioprotection after Myocardial Infarction [0.03%]
富血小板血浆水凝胶心肌梗死后超急性期心脏保护作用
Tomohiro Murata,Yasuo Miyagi,Ryosuke Amitani et al.
Tomohiro Murata et al.
Alternative therapies are needed for heart failure following myocardial infarction (MI), as ischemic cardiomyopathy remains a major global health concern despite advances in acute MI management. Platelet-rich plasma (PRP), which is enriched...