Depletion of MicroRNA-100-5p Promotes Osteogenesis Via Lysine(K)-Specific Demethylase 6B [0.03%]
微核糖核酸-100-5p缺乏通过赖氨酸特异性去甲基化酶6B促进成骨作用
Xiaokang Gong,Xi Chen,Zhulong Meng et al.
Xiaokang Gong et al.
Senescence and osteogenic differentiation potential loss limited bone nonunion treatment effects of bone marrow-derived mesenchymal stem cells (BMSCs). MiR-100-5p/Lysine(K)-specific demethylase 6B (KDM6B) can inhibit osteogenesis, but their...
Association with Cationized Gelatin Nanospheres Enhances Mitochondria Uptake and Membrane Potential [0.03%]
阳离子明胶纳米球化提高了线粒体的摄取和膜电位
Wenxuan Yang,Satoshi Abe,Mitsuru Ando et al.
Wenxuan Yang et al.
The objective of this study is to investigate the influence of exogenous mitochondria (Mt) internalization on the Mt membrane potential of cells. Cationized gelatin nanospheres (cGNS) were prepared to mix Mt at different ratios to prepare M...
Repair of Osteochondral Defect with Acellular Cartilage Matrix and Thermosensitive Hydrogel Scaffold [0.03%]
脱细胞软骨基质联合热敏性水凝胶支架修复骨软骨缺损
Shengtao Zou,Guochao Xu,Zhenyu Zheng et al.
Shengtao Zou et al.
In the present study, acellular cartilage matrix (ACM) was modified with poly-l-lysine/hyaluronic acid (PLL/HA) multilayers via detergent-enzyme chemical digestion and layer-by-layer self-assembly technology. This modified ACM was then load...
A Composite Foam of Dermal Matrix-Demineralized Bone Matrix for Enhanced Bone Regeneration [0.03%]
一种用于骨再生的真皮基质-脱矿骨基质复合泡沫
Tong Ma,Jingjing Wang,Dangli Ren et al.
Tong Ma et al.
Allogenic demineralized bone matrix (DBM) is widely used for bone repair and regeneration due to its osteoinductivity and osteoconductivity. The present study utilized acellular dermis microfibers to improve the DBM's clinical handling prop...
Evaluation of Dexamethasone-Eluting Cell-Seeded Constructs in a Preclinical Canine Model of Cartilage Repair [0.03%]
评价地塞米松缓释细胞种子支架修复软骨缺损的临床前犬模型中的效果研究
Andy J Lee,Lianna R Gangi,Yizhong Jenny Hu et al.
Andy J Lee et al.
In this 12-month long, preclinical large animal study using a canine model, we report that engineered osteochondral grafts (comprised of allogeneic chondrocyte-seeded hydrogels with the capacity for sustained release of the corticosteroid d...
Perspectives on Recent Developments and Directions in Tissue Engineering and Regenerative Medicine [0.03%]
组织工程和再生医学的最新进展及未来方向展望
Nasim Annabi,Elizabeth Cosgriff-Hernandez,Anthony S Weiss
Nasim Annabi
This perspective article draws on lessons learned at the 7th TERMIS World Congress held in Seattle, Washington in June 2024. This gathering of prominent researchers and translational scientists in tissue engineering and regenerative medicin...
Applications of Regenerative Tissue-Engineered Scaffolds for Treatment of Spinal Cord Injury [0.03%]
用于治疗脊髓损伤的再生组织工程支架的应用
Katherine J Bradshaw,Nic D Leipzig
Katherine J Bradshaw
Tissue engineering provides a path forward for emerging personalized medicine therapies as well as the ability to bring about cures for diseases or chronic injuries. Traumatic spinal cord injuries (SCIs) are an example of a chronic injury i...
Differentiated and Untreated Juvenile Chondrocyte Sheets Regenerate Cartilage Similarly In Vivo [0.03%]
体外分化和非分化的软骨细胞片在体内再生软骨的过程中表现相似
Nicolás F Metzler,Makoto Kondo,Keisuke Matsukura et al.
Nicolás F Metzler et al.
Osteoarthritis, a degenerative disease of articular cartilage and the leading cause of disability, is preceded by acute cartilage injury in a significant proportion of cases. Current auto- and allograft interventions are limited by supply a...
Effects of Release of TSG-6 from Heparin Hydrogels on Supraspinatus Muscle Regeneration [0.03%]
TSG-6释放对肩袖肌肉再生的四氧化三氢水凝胶的作用研究
Joseph J Pearson,Jiahui Mao,Johnna S Temenoff
Joseph J Pearson
Muscle degeneration after rotator cuff tendon tear is a significant clinical problem. In these experiments, we developed a poly(ethylene glycol)-based injectable granular hydrogel containing two heparin derivatives (fully sulfated [Hep] and...
Decellularized Extracellular Matrix Improves Mesenchymal Stromal Cell Spheroid Response to Chondrogenic Stimuli [0.03%]
脱细胞基质改善间充质干细胞球对软骨生成刺激的反应
David H Ramos-Rodriguez,Shierly W Fok,Connor J Dorais et al.
David H Ramos-Rodriguez et al.
Cartilage regeneration is hindered due to the low proliferative capacity of chondrocytes and the avascular nature of cartilaginous tissue. Mesenchymal stromal cells (MSCs) are widely studied for cartilage tissue engineering, and the aggrega...