* Demineralized Bone Matrix as a Carrier for Bone Morphogenetic Protein-2: Burst Release Combined with Long-Term Binding and Osteoinductive Activity Evaluated In Vitro and In Vivo [0.03%]
脱矿骨基质作为骨形态发生蛋白-2载体：体内外评价burst释放与长期结合及诱导成骨作用
Elisabeth Huber,Anne-Marie Pobloth,Nicole Bormann et al.
Elisabeth Huber et al.
To allow bone defect regeneration, autologous bone grafting still represents the gold standard. However, autograft harvesting has limitations, including an additional surgery, donor site morbidity, and limited availability. Demineralized bo...
Bone Morphogenetic Protein 2 Alters Osteogenesis and Anti-Inflammatory Profiles of Mesenchymal Stem Cells Induced by Microtextured Titanium In Vitro<sup/> [0.03%]
骨形态发生蛋白2通过体外实验改变微纹理钛诱导的间充质干细胞成骨和抗炎表型
Sharon L Hyzy,Rene Olivares-Navarrete,Sarah Ortman et al.
Sharon L Hyzy et al.
Objectives: Microtextured titanium (Ti) induces osteoblast differentiation of mesenchymal stem cells (MSCs) in the absence of exogenous osteogenic factors; and high-energy surface modifications speed healing of microrough...
Bone Regenerative Medicine in Oral and Maxillofacial Region Using a Three-Dimensional Printer<sup/> [0.03%]
应用三维打印技术的颌面骨组织再生修复研究进展
Atsuhiko Hikita,Ung-Il Chung,Kazuto Hoshi et al.
Atsuhiko Hikita et al.
Bone grafts currently used for the treatment of large bone defect or asymmetry in oral and maxillofacial region include autologous, allogeneic, and artificial bones. Although artificial bone is free from the concerns of donor site morbidity...
* Understanding the Spatiotemporal Degradation Behavior of Aggrecanase-Sensitive Poly(ethylene glycol) Hydrogels for Use in Cartilage Tissue Engineering [0.03%]
一种用于软骨组织工程的aggrecanase响应型聚乙二醇水凝胶的时空降解行为研究
Stanley Chu,Shankar Lalitha Sridhar,Umut Akalp et al.
Stanley Chu et al.
Enzyme-sensitive hydrogels are promising cell delivery vehicles for cartilage tissue engineering. However, a better understanding of their spatiotemporal degradation behavior and its impact on tissue growth is needed. The goal of this study...
* Design of an In Vitro Model of Cell Recruitment for Skeletal Muscle Regeneration Using Hepatocyte Growth Factor-Loaded Fibrin Microthreads [0.03%]
基于装载HGF的微纤维原代细胞的体外肌组织模型的设计及应用研究
Jonathan M Grasman,Raymond L Page,George D Pins
Jonathan M Grasman
Large skeletal muscle defects that result in volumetric muscle loss (VML) result in the destruction of the basal lamina, which removes key signaling molecules such as hepatocyte growth factor (HGF) from the wound site, eliminating the endog...
* Hierarchically Structured Electrospun Scaffolds with Chemically Conjugated Growth Factor for Ligament Tissue Engineering [0.03%]
具有化学接枝生长因子的分层结构电纺支架用于韧带组织工程
Hannah M Pauly,Binulal N Sathy,Dinorath Olvera et al.
Hannah M Pauly et al.
The anterior cruciate ligament (ACL) of the knee is vital for proper joint function and is commonly ruptured during sports injuries or car accidents. Due to a lack of intrinsic healing capacity and drawbacks with allografts and autografts, ...
Activation of Macrophages by Lipopolysaccharide for Assessing the Immunomodulatory Property of Biomaterials<sup/> [0.03%]
通过脂多糖活化巨噬细胞来评估生物材料的免疫调节性能
Shengwei Han,Zetao Chen,Pingping Han et al.
Shengwei Han et al.
The design paradigm of biomaterials has been changed to ones with favorable immunomodulatory effects, indicating the importance of accurately evaluating the immunomodulatory properties of biomaterials. Among all the immune cells macrophages...
Priming Adipose Stem Cells with Tumor Necrosis Factor-Alpha Preconditioning Potentiates Their Exosome Efficacy for Bone Regeneration [0.03%]
肿瘤坏死因子α预处理可以活化脂肪干细胞来源的外泌体促进骨再生
ZuFu Lu,YongJuan Chen,Colin Dunstan et al.
ZuFu Lu et al.
Mesenchymal stem cells (MSCs) have been widely used for tissue repair and regeneration. However, the inherent drawbacks, including limited cell survival after cell transplantation, have hindered direct MSC transplantation for tissue repair ...
* Substituted Borosilicate Glasses with Improved Osteogenic Capacity for Bone Tissue Engineering [0.03%]
具有改善成骨能力的硼硅酸盐玻璃用于骨组织工程
João S Fernandes,Piergiorgio Gentile,Aileen Crawford et al.
João S Fernandes et al.
Borosilicate bioactive glasses (BBGs) have shown the capacity to promote higher formation of new bone when compared with silicate bioactive glasses. Herein, we assessed the capacity of BBGs to induce osteogenic differentiation of bone marro...
* Harnessing External Cues: Development and Evaluation of an In Vitro Culture System for Osteochondral Tissue Engineering [0.03%]
利用外部线索培育软骨细胞及软骨组织体外培养体系的建立及评估
Deborah L Dorcemus,Eve O George,Caroline N Dealy et al.
Deborah L Dorcemus et al.
Over the last decade, engineered structures have been developed for osteochondral (OC) tissue regeneration. While the optimal structure design is yet to be determined, these scaffolds require in vitro evaluation before clinical use. However...