Imaging-guided optimization of biodistribution and antitumor efficacy of L19-based immunocytokines [0.03%]
影像引导的L19免疫细胞因子肿瘤靶向性和疗效优化研究
Tommaso Virgilio,Kamil Chahine,Jordi Guixeras Carreras et al.
Tommaso Virgilio et al.
Antibody-based targeted delivery of pharmaceuticals is an attractive approach to preferentially localize anti-cancer payloads to neoplastic lesions. The L19 antibody, specific for the extra domain B of fibronectin, is used in several antibo...
FOSL1 promotes homologous recombination repair and camptothecin resistance via TCOF1-mediated ribosome biogenesis in non-small cell lung cancer [0.03%]
FOSL1通过TCOF1介导的核糖体生物发生促进非小细胞肺癌中的同源重组修复和喜树碱抗性
Chunmei Hao,Luojun Chen,Fuben Liao et al.
Chunmei Hao et al.
Background: Camptothecin (CPT) and its derivatives are important chemotherapeutic agents; however, intrinsic and acquired tolerance frequently limits their long-term efficacy. This study aimed to identify key transcriptio...
OSBPL3 promotes LUAD metastasis and glycolysis through transcriptional upregulation of PLAU via NFE2L2 [0.03%]
OSBPL3通过NFE2L2转录上调PLAU促进LUAD转移和糖酵解
Qingqiong Zhang,Jingshun Zhang,Junxian Li et al.
Qingqiong Zhang et al.
The progression of lung adenocarcinoma (LUAD) involves multiple molecular determinants, among which Oxysterol-binding protein-like 3 (OSBPL3) has been suggested to contribute to tumorigenesis, though its functional significance in LUAD rema...
An unfavorable biologic profile associated with decreased overall survival and cancer-specific survival in non-metastatic breast cancer: A latent class analysis [0.03%]
不利的生物学特征与非转移性乳腺癌患者的总生存率和癌症特异性生存率降低有关：潜在类别分析
Claire Falandry,Sigrid Hatse,Barbara Brouwers et al.
Claire Falandry et al.
Background: Chronological age is an imperfect proxy for risk assessment in geriatric oncology. There is an urgent need for an objective, easily measurable biological aging signature to refine patient stratification and pe...
Piperlongumine suppresses YAP-ET-1-CXCL2 signaling to modulates aggressiveness of triple-negative breast cancer cells [0.03%]
胡椒长柏碱通过抑制YAP-ET-1-CXCL2信号通路来调控三阴性乳腺癌细胞的侵袭行为
Ming-Yi Hsieh,Ching-Chieh Yang,Wen-Jing Hsu et al.
Ming-Yi Hsieh et al.
Triple-negative breast cancer (TNBC) is characterized by highly aggressive and metastatic properties, and appropriate molecular targets and therapeutics for effective treatment remain limited. In the present study, by using RNA sequencing (...
The novel tertiary amine LSD1 inhibitor 596 inhibits endometrial cancer through the mTOR signal transduction pathway [0.03%]
新型季铵类LSD1抑制剂596通过mTOR信号转导途径抑制子宫内膜癌
Chunli Wang,Dandan Shen,Nanshan Lin et al.
Chunli Wang et al.
Lysine-specific demethylase 1 (LSD1) is a promising target in cancer therapy and plays an important role in the occurrence and development of tumors. However, research on LSD1 in endometrial cancer (EC) is indeed limited, and the related re...
Multi-omics analysis of NET+ TAN explains the immunosuppressive TME and prognosis value of malignant clinical characteristics in TNBC [0.03%]
NET+/TAN的多组学分析解释了三阴性乳腺癌免疫抑制型肿瘤微环境及恶性临床特征的预后价值
Qiannan Zhu,Xiangxin Zheng,Xiaochao Zhu et al.
Qiannan Zhu et al.
Triple-negative breast cancer (TNBC) continues to exhibit a poor response to both immunotherapy and endocrine therapy, primarily due to its complex genetic heterogeneity and tumor immune microenvironment (TIME). Neutrophil extracellular tra...
Overcoming the leptomeningeal seeding of medulloblastoma by targeting HSP70 [0.03%]
靶向HSP70抑制髓母细胞瘤的脑膜转移种植复发
Seung Ah Choi,Sokhoeun Heng,Saehim Ha et al.
Seung Ah Choi et al.
Leptomeningeal seeding (LMS) via cerebrospinal fluid is a common and often fatal progression in medulloblastoma (MB), significantly worsening prognosis. However, its molecular drivers are poorly understood, and effective treatments remain l...
SPP1⁺ macrophage-FADS1⁺ tumor cell crosstalk via the PDGFB-PDGFRB axis drives liver metastasis in colorectal cancer [0.03%]
结直肠癌中SPP1⁺巨噬细胞与FADS1⁺肿瘤细胞通过PDGFB-PDGFRB轴相互作用驱动肝转移
Pingfan Zhao,Fuyong Pei,Yanmin Liu et al.
Pingfan Zhao et al.
Liver metastasis is the predominant cause of mortality among individuals diagnosed with colorectal cancer (CRC). However, the mechanisms underlying the tumor-microenvironment interactions that promote this process remain poorly defined. Her...
Siyi Wu,Zaiyu Wang,Yu Zhang et al.
Siyi Wu et al.
Head and neck squamous cell carcinoma (HNSCC) is the most prevalent histopathological subtype of head and neck malignancies. Owing to the lack of early specific symptoms, the majority of patients are diagnosed at intermediate or advanced st...