Clostridium Butyricum and butyrate enhance PD-1 inhibitor therapy in non-small cell lung cancer by regulating the HDAC1/ID2/IL-12R pathway [0.03%]
丙酸杆菌和丁酸通过调控HDAC1/ID2/IL-12R信号轴增强非小细胞肺癌PD-1抑制剂治疗效果
Zhuo Chen,Meng-Lei Wang,Zhuo-Wen Zhang et al.
Zhuo Chen et al.
Background: PD-1 blockade has become an important immunotherapeutic strategy, its clinical efficacy in non-small cell lung cancer (NSCLC) remains suboptimal. This study explores the effect and mechanism of sodium butyrate...
Superior in-vivo efficacy of integrated tumor neoantigen vaccination with adoptive neoantigen-reactive T-cell therapy in solid tumor [0.03%]
整合肿瘤新抗原疫苗与过继性新抗原反应T细胞治疗在实体瘤中具有优异的体内疗效
Guozheng Liang,Boyue Zhang,Dan Chen et al.
Guozheng Liang et al.
Objective: Neoantigens from tumor mutations are key cancer immunotherapy targets. This study evaluated the efficacy of combined immunotherapy (neoantigen vaccines + adoptive neoantigen-reactive T cells, NRT) in solid tumo...
Dynamic body mass index trajectories are associated with survival outcomes in advanced Hepatocellular Carcinoma treated with immunotherapy [0.03%]
动态体重指数变化与免疫治疗晚期肝细胞癌患者生存预后相关性研究
Shuifang Hu,Mingcong Xu,Ziniu Liu et al.
Shuifang Hu et al.
Background and objective: Obesity paradoxically increases both cancer risk and anti-tumor efficacy. However, the prognostic association of dynamic body mass index (BMI) trajectories in advanced hepatocellular carcinoma (H...
SLC2A3 knockdown enhances radiosensitivity and suppresses MAPK signaling in nasopharyngeal carcinoma [0.03%]
SLC2A3敲低增强放射敏感性并通过抑制MAPK信号传导抑制鼻咽癌发生发展
Xinting Ouyang,Weijiang Zhu,Qiang Yi et al.
Xinting Ouyang et al.
Background: Nasopharyngeal carcinoma (NPC) is a type of epithelial malignancy, where radioresistance significantly hinders effective treatment and favorable prognosis. This study aims to elucidate how solute carrier famil...
Identification of a three-gene prognostic signature associated with tumor immune characteristics in lung adenocarcinoma: A comprehensive analysis of multi-omics data [0.03%]
基于多组学数据的肺腺癌预后基因标志物的筛选及免疫相关特征分析
Huangkai Zhu,Yanna Fang,Minglei Yang et al.
Huangkai Zhu et al.
Lung adenocarcinoma (LUAD) is a highly heterogeneous malignancy with substantial differences in clinical outcomes and therapeutic responses. However, robust molecular signatures integrating prognostic stratification with tumor biological an...
Integration of single-cell transcriptomics and genomic mutation analysis identifies an immunotherapy-resistant tumor subcluster and validates ARNTL2 as a malignant driver in lung adenocarcinoma [0.03%]
单细胞转录组和基因组突变分析的整合鉴定出一种免疫治疗抵抗性肺癌肿瘤亚簇，并证实ARNTL2为肺腺癌恶性驱动基因
Zhengang Qiu,Hui Zhao,Qiong Lyu et al.
Zhengang Qiu et al.
Background: Immunotherapy resistance in lung adenocarcinoma (LUAD) remains a critical clinical challenge, and the mechanisms underlying resistance-associated intratumoral heterogeneity are poorly characterized. ...
DLST drives lung adenocarcinoma progression by modulating cuproptosis-related copper homeostasis and apoptosis via an EP300-dependent mechanism [0.03%]
DLST通过EP300依赖机制调节铜死亡相关的铜稳态和凋亡驱动肺腺癌进展
Tonghai Huang,Lin Chen,Zeyao Li et al.
Tonghai Huang et al.
Background: Dihydrolipoamide S-succinyltransferase (DLST), a key enzyme in the tricarboxylic acid cycle, has recently been implicated in cuproptosis. However, its role in lung adenocarcinoma (LUAD) remains unclear. ...
TCGA-based identification and functional validation of PBK in intrahepatic cholangiocarcinoma progression with involvement of AKT signaling [0.03%]
基于TCGA的PBK在肝内胆管癌进展中的鉴定及功能验证及其对AKT信号的影响
Xiangtian Shi,Lei Zhang,Tengqi Wang et al.
Xiangtian Shi et al.
Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with limited molecular targets. This study aimed to identify candidate genes involved in ICC progression and to examine the functional role of PBK. Integrated bioinformatics ...
Age-related prognostic disparities in cutaneous melanoma: A population-based study and validated interactive web-based nomogram for individualized prognostic stratification [0.03%]
基于人群的年龄相关黑色素瘤预后差异研究以及用于个体化分层的已验证交互式网络列线图
Wenhao Xu,Li Zheng,Qinqin Chen et al.
Wenhao Xu et al.
Background: Cutaneous melanoma (CM) in older adults (≥65 years) has distinct clinicopathological features and poorer survival than in younger adults. We evaluated age-related cancer-specific survival (CSS), prognostic as...
Prediction models for adverse events from prostate cancer curative radiotherapy: a systematic review of methodological quality [0.03%]
系统评价：前列腺癌根治放疗毒性预测模型的方法学质量评价
Claudia Cruz Oliveira,Christian A M Jongen,Ana Mikolić et al.
Claudia Cruz Oliveira et al.
Background: Predicting risks of urinary, bowel, sexual, and other adverse effects following prostate cancer curative radiotherapy (PCa-RT) is essential for treatment personalization and patient counseling. Several clinica...