Age-related prognostic disparities in cutaneous melanoma: A population-based study and validated interactive web-based nomogram for individualized prognostic stratification [0.03%]
基于人群的年龄相关黑色素瘤预后差异研究以及用于个体化分层的已验证交互式网络列线图
Wenhao Xu,Li Zheng,Qinqin Chen et al.
Wenhao Xu et al.
Background: Cutaneous melanoma (CM) in older adults (≥65 years) has distinct clinicopathological features and poorer survival than in younger adults. We evaluated age-related cancer-specific survival (CSS), prognostic as...
Prediction models for adverse events from prostate cancer curative radiotherapy: a systematic review of methodological quality [0.03%]
系统评价：前列腺癌根治放疗毒性预测模型的方法学质量评价
Claudia Cruz Oliveira,Christian A M Jongen,Ana Mikolić et al.
Claudia Cruz Oliveira et al.
Background: Predicting risks of urinary, bowel, sexual, and other adverse effects following prostate cancer curative radiotherapy (PCa-RT) is essential for treatment personalization and patient counseling. Several clinica...
Intercellular mitochondrial exchange shapes tumor evolution, microenvironment adaptation, and therapeutic vulnerabilities [0.03%]
细胞间线粒体交换塑造肿瘤进化、微环境适应和治疗弱点
Zhiyong Wu,Jianhao Bai,Aiqin Chang et al.
Zhiyong Wu et al.
Mitochondrial transfer has emerged as a previously underappreciated mode of intercellular communication with major implications for tumor biology. Beyond their cell-autonomous roles in bioenergetics and signalling, mitochondria can be excha...
Integrated single-cell and bulk transcriptomic analysis identifies a novel senescent fibroblast subtype associated with poor prognosis in acral melanoma [0.03%]
整合单细胞和批量转录组分析揭示了一种与肢端黑色素瘤预后不良相关的新衰老成纤维细胞亚型
Ming Jing,Zhen Xu,Zhenqiang Ruan et al.
Ming Jing et al.
Background: Acral melanoma (AM) exhibits significant intratumoral heterogeneity, but its tumor microenvironment (TME) and immune regulation remain unclear. This study aims to dissect TME heterogeneity and establish a prog...
Citrullination-associated transcriptional states identify a non-canonical invasive program in malignant epithelial cells and correlate with SPP1-CD44 immune microenvironment niches in thyroid cancer [0.03%]
瓜氨酸化相关的转录状态识别恶性上皮细胞中的非典型侵袭程序并与甲状腺癌中SPP1-CD44免疫微环境生态位相关
Zhisheng Tian,Peiling Zhu,Xiujuan Zhao et al.
Zhisheng Tian et al.
Background: Citrullination, a post-translational modification catalyzed by protein arginine deiminases (PADIs), has been implicated in malignant progression across multiple cancer types. However, its cellular distribution...
Unveiling the power of TIIC: A prognostic tool for esophageal adenocarcinoma [0.03%]
揭示TIICs的力量：一种食管腺癌预后工具
Shaolin Gao,Bing Du,Yeju He et al.
Shaolin Gao et al.
Background: Esophageal adenocarcinoma (EAC) remains a lethal malignancy with limited prognostic tools for guiding immunotherapy. Tumor-infiltrating immune cells (TIICs) play a critical role in EAC prognosis and treatment ...
Discovery of indazole-carboxamide based USP8 inhibitor for immune activation and antitumor response in colorectal cancer [0.03%]
用于免疫激活和结直肠癌抗肿瘤反应的新型吲达唑羧酰胺类USP8抑制剂的发现
Zhiyu Song,Yuanying Wang,Weiwei Zhou et al.
Zhiyu Song et al.
Background: Microsatellite-stable colorectal cancer (CRC), which accounts for most CRC cases, responds poorly to immune checkpoint inhibitors. Increasing evidence suggests that the deubiquitinase USP8 maintains PD-L1 prot...
Adjuvant apatinib therapy following concurrent chemoradiotherapy in patients with high-risk nasopharyngeal carcinoma: A multicenter, prospective phase 2 study [0.03%]
同期放化疗后派安普利单抗辅助治疗高危鼻咽癌患者：一项前瞻性Ⅱ期临床研究
Chen Huang,Jinmei Huang,Yunyan Mo et al.
Chen Huang et al.
Purpose: To assess the efficacy and safety of concurrent chemoradiotherapy (CCRT) combined with apatinib in locoregionally advanced nasopharyngeal carcinoma (LA-NPC). ...
Single-cell transcriptomics uncovers HPV-driven immune evasion and establishes a TAB2-based prognostic signature in cervical cancer [0.03%]
单细胞转录组揭示HPV驱动的免疫逃逸并建立宫颈癌预后标志物TAB2
Jiarui Mi,Wenzhe Guo,Li Li et al.
Jiarui Mi et al.
Background: Persistent human papillomavirus (HPV) infection is a key driver in cervical cancer, yet the molecular mechanisms linking HPV to immune escape remain incompletely understood. ...
Size-exclusion chromatography as a clinically applicable method for extracellular vesicles collection as liquid biopsies shows potential diagnostic relevance and correlation with poorer outcome in common cancer types [0.03%]
尺寸排除色谱法作为一种临床适用的液态活检技术收集细胞外囊泡显示其在常见癌症类型中的潜在诊断价值及不良预后相关性
Szilárd-Krisztián Belényesi,Seán Patmore,Sinead Hurley et al.
Szilárd-Krisztián Belényesi et al.
Increasing evidence suggests extracellular vesicles (EVs) are key components of liquid biopsies to aid cancer diagnosis and treatment selection, if their collection can be translated to clinical settings. Size exclusion chromatography (SEC)...