Lactylation profiling reveals novel biomarkers and immune interactions in pancreatic cancer [0.03%]
丙酮酸羧化酶的生理性调节及其在代谢性疾病中的病理生理作用
Dong Xu,Qiuyang Chen,Liang Wang et al.
Dong Xu et al.
Pancreatic cancer, known for its aggressive nature and poor prognosis, often eludes early detection and effective treatment. This study investigates the underexplored terrain of protein lactylation in pancreatic cancer to identify potential...
Somatic mutations in cervicovaginal samples: assessing their role in ovarian cancer detection and prognosis [0.03%]
宫颈阴道涂片中的体细胞突变在卵巢癌诊断和预后评估中的作用分析
Beatriz Pelegrina,Sonia Paytubi,Yolanda Benavente et al.
Beatriz Pelegrina et al.
Background: Most patients with ovarian cancer are diagnosed at a late stage because of the lack of early stage symptoms or effective screening methods. To address this issue, we evaluated the presence of DNA somatic varia...
Rebecca Lyons,Stephen G Maher,Joanne Lysaght
Rebecca Lyons
The prognosis for patients diagnosed with pancreatic cancer has changed little over the past 4 decades. Fewer than 20 % of patients are diagnosed at a stage amenable to potentially curative surgery and therapeutic resistance remains widespr...
SELE is associated with reduced breast cancer susceptibility: Evidence from Mendelian randomization and single-cell transcriptome [0.03%]
SELE与降低乳腺癌易感性相关：来自孟德尔随机化和单细胞转录组的证据
Hanghang Chen,Weihua Hu,Ruidong Liu et al.
Hanghang Chen et al.
Background: The role of circulating proteins in breast cancer (BC) early diagnosis remains unclear. We investigated genetically predicted associations between circulating proteins and BC risk using Mendelian randomization...
REST-driven upregulation of SFXN3 promotes AML progression via Wnt/β-catenin activation and confers decitabine resistance [0.03%]
REST上调SFXN3促进急性髓系白血病进展及地西他滨耐药的新机制研究
Xiaoling Wang,Youcai Huang,Mingwei Sun et al.
Xiaoling Wang et al.
One of the most diverse types of blood cancer is acute myeloid leukemia, or AML, and there remains an urgent need to identify novel molecular targets for its diagnosis and treatment. The present investigation identified Sideroflexin 3 (SFXN...
Encapsulation of hydroxyurea in exosomes derived from adipose mesenchymal stem cells enhances anticancer efficacy in breast cancer [0.03%]
来源于脂肪间充质干细胞的外泌体封装羟基脲可增强其抗乳腺癌功效
Zohreh Taheri Kangarshahi,Shahla Mohammad Ganji,Fatemeh Ashrafi et al.
Zohreh Taheri Kangarshahi et al.
Breast cancer treatment faces numerous challenges, including drug resistance and lack of precise drug targeting, which reduce therapeutic efficacy. This study investigated the potential use of hydroxyurea (HU), a potent antimetabolite, and ...
Clinicopathological and functional evaluation of replication protein A in epithelial ovarian cancers: A target validation study [0.03%]
上皮性卵巢癌中复制蛋白A的临床病理和功能评价：一项目标验证研究
Mashael Algethami,Amera Sheha,Nehal Singhania et al.
Mashael Algethami et al.
Replication Protein A (RPA), a single-stranded DNA (ssDNA)-binding protein is critically involved in DNA replication, checkpoint regulation and DNA repair. We evaluated RPA1, 2, and 3 sub-units protein expression in 331 ovarian tumours, tra...
Integrative bioinformatics identifies NSCLC biomarkers associated with LPS metabolism and circadian disruption [0.03%]
整合生物信息学鉴定出与LPS代谢和昼夜节律紊乱相关的NSCLC生物标志物
Yu Chen,Yifan Zhao,Qinghua Kong et al.
Yu Chen et al.
Purpose: Non-small cell lung carcinoma (NSCLC) is a leading cause of cancer-related mortality worldwide, highlighting the urgent need for early detection and targeted therapies. While lipopolysaccharide (LPS) metabolism a...
The VAX2-SERPINE1 axis modulates colorectal cancer cell proliferation and apoptosis through WNT/beta-catenin signaling [0.03%]
VAX2-SERPINE1轴通过WNT/β-catenin信号转导调控结直肠癌细胞增殖和凋亡
Jieming Zhang,Guangnan Liu,Siyang Peng et al.
Jieming Zhang et al.
Transcription factors (TFs) involve in colorectal cancer (CRC). However, the function and mechanism of VAX2 in the development of CRC remain barely known. In the present study, we observed that transcription factor VAX2 is frequently upregu...
A review of treatment strategies for elderly patients with Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia [0.03%]
老年Ph染色体阴性B细胞急性淋巴细胞白血病治疗策略的研究进展
Kaihang Shi,Gaoxiang Wang,Xueyan Sun
Kaihang Shi
The treatment of elderly patients with Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia (pH⁻ B-ALL) remains challenging because of the high frequency of adverse genetic features, common comorbidities, and significant tr...