Intratumoral heterogeneity after targeted therapy in murine cancer models with differing degrees of malignancy [0.03%]
在不同程度恶性程度的小鼠癌症模型中靶向治疗后的肿瘤异质性变化研究
M Gerwing,E Hoffmann,C Geyer et al.
M Gerwing et al.
Introduction: Conventional morphologic and volumetric assessment of treatment response is not suitable for adequately assessing responses to targeted cancer therapy. The aim of this study was to evaluate changes in tumor ...
Overexpression of CD2/CD27 could inhibit the activation of nitrogen metabolism pathways and suppress M2 polarization of macrophages, thereby preventing brain metastasis of breast cancer [0.03%]
过表达CD2/CD27能抑制氮代谢通路的激活，从而抑制乳腺癌脑转移灶小胶质细胞M2极化
Guanyou Huang,Yujuan Wu,Hongchuan Gan et al.
Guanyou Huang et al.
Objective: Our study aimed to reveal the possible molecular mechanisms of CD2 and CD27 in influencing the tumor microenvironment of breast cancer (BC) brain metastasis based on the TCGA (The Cancer Genome Atlas) and SRA (...
EGFR mutation testing from pleural effusions of non-small cell lung cancer patients at the institute for oncology and radiology of Serbia [0.03%]
塞尔维亚放射肿瘤研究院非小细胞肺癌患者胸水中表皮生长因子受体突变检测
Miodrag Vukovic,Miljana Tanic,Ana Damjanovic et al.
Miodrag Vukovic et al.
Background: The use tumor-derived cell-free DNA extracted from body fluids is being evaluated for genetic testing in lung cancer. The aim of this study was to explore the feasibility and utility of implementation of EGFR ...
Circulating tumor DNA based minimal residual disease detection and adjuvant treatment decision-making for muscle-invasive bladder cancer guided by modern clinical trials [0.03%]
基于循环肿瘤DNA的最小残余病灶检测和肌肉浸润性膀胱癌的辅助治疗决策（由现代临床试验指导）
Cayce Nawaf,Alexander Shiang,Pradeep S Chauhan et al.
Cayce Nawaf et al.
Up to 430,000 cases of bladder cancer are diagnosed each year worldwide. A proposed method for non-invasive monitoring has been to utilize a "liquid biopsy." Liquid biopsy has been proposed as a non-invasive method of testing biomarkers in ...
Evaluation of a semi-automated approach for FDG PET image analysis for routine clinical application in patients with multiple myeloma [0.03%]
评估半自动FDG-PET图像分析方法的临床应用价值：用于多发性骨髓瘤患者的常规临床应用评估研究
Tyler J Wellman,Sarah R Mudd,Kelly N Godby et al.
Tyler J Wellman et al.
Background: FDG PET/CT is a tool for assessing response to therapy in various cancers, and may provide an earlier biomarker of clinical response. We developed a novel semi-automated approach for analyzing FDG PET/CT image...
Changes in leukoencephalopathy and serum neurofilament after (neo)adjuvant chemotherapy for breast cancer [0.03%]
乳腺癌术前后化疗对脑白质病变及血清神经丝蛋白的影响研究
Gwen Schroyen,Charlotte Sleurs,Tine Ottenbourgs et al.
Gwen Schroyen et al.
Background: Previous case studies have provided evidence for chemotherapy-induced leukoencephalopathy in patients with breast cancer. However, prospective research is lacking. Hence, we investigated leukoencephalopathy be...
IGF2BP3 drives gallbladder cancer progression by m6A-modified CLDN4 and inducing macrophage immunosuppressive polarization [0.03%]
IGF2BP3通过m6A修饰CLDN4及诱导巨噬细胞免疫抑制极化驱动胆囊癌进展
Jian Qin,Zheng Cui,Jingyi Zhou et al.
Jian Qin et al.
Introduction: N6-methyladenosine (m6A) is an emerging epigenetic modification, which plays a crucial role in the development of cancer. Nevertheless, the underlying mechanism of m6A-associated proteins and m6A modificatio...
PPFIBP1 activates NF-κB signaling to enhance chemoresistance of multiple myeloma [0.03%]
PPFIBP1通过激活NF-κB信号通路增强多发性骨髓瘤的化疗耐药性
Yi Deng,Lanting Chen,Qiguo Zhang et al.
Yi Deng et al.
Easily developed chemoresistance is a major characteristic of multiple myeloma (MM) and the main obstacle in curing MM in the clinic, but the key regulators have not been fully identified. In the current study, we find that PPFIA Binding Pr...
Comprehensive analysis for the immune related biomarkers of platinum-based chemotherapy in ovarian cancer [0.03%]
铂类化疗在卵巢癌免疫相关生物标志物中的综合分析
Jiao Liu,Yaoyao Liu,Chunjiao Yang et al.
Jiao Liu et al.
Background: Ovarian cancer (OC) is one of the most lethal gynecological malignancies. This study aimed to identify biomarkers that were sensitive to platinum-based chemotherapeutic agents and can be used in immunotherapy ...
Stochastic epithelial-mesenchymal transitions diversify non-cancerous lung cell behaviours [0.03%]
随机上皮间质转化可多样化非癌肺细胞的行为反应
Sugandha Bhatia,Jennifer H Gunter,Joshua T Burgess et al.
Sugandha Bhatia et al.
Epithelial-mesenchymal plasticity (EMP) is a hallmark of cancer. By enabling cells to shift between different morphological and functional states, EMP promotes invasion, metastasis and therapy resistance. We report that near-diploid non-can...